DNA Viruses Use Host Cell Machinery to Transcribe mRNA
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Must look like host DNA
Promoter
Enhancers
Must mimic host transcription termination signals
, All DNA viruses including Retroviridae and Hepadnaviridae
Exception: Poxviridae
Replicates in cytoplasm
Performs these functions
DNA Viruses Trends: Which are True?
A. All small DNA viruses replicate in the nucleus
B. All large DNA viruses replicate in the nucleus
C. A+B
D. Neither
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A. All small DNA viruses replicate in the nucleus
[EXCEPTION: Pox which is large so it replicates in the cytoplasm]
Problems for all viruses to overcome:
Give this one a try later!
, How to get into the cell
How to uncoat
Cellular Defense systems
How to deal with Actin: actin remodelling
How to get to site of replication
How to mimic cellular mRNAs
Eukaryotic translation only monocistronic mRNA
Viral and cellular mRNA are in competition for translation machinery
Initiating genome replication
Replicating the ends of the genome
Packaging the genome
How to get out of the cell
The host's immune response
True or False: All large DNA viruses (>50 kb) are enveloped
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TRUE
[Pox and Herpes are the only two that are more than 50kb]
What Starts DNA Replication: for Polyoma, Papilloma, and Herpes?
Give this one a try later!
Must look like host DNA
Promoter
Enhancers
Must mimic host transcription termination signals
, All DNA viruses including Retroviridae and Hepadnaviridae
Exception: Poxviridae
Replicates in cytoplasm
Performs these functions
DNA Viruses Trends: Which are True?
A. All small DNA viruses replicate in the nucleus
B. All large DNA viruses replicate in the nucleus
C. A+B
D. Neither
Give this one a try later!
A. All small DNA viruses replicate in the nucleus
[EXCEPTION: Pox which is large so it replicates in the cytoplasm]
Problems for all viruses to overcome:
Give this one a try later!
, How to get into the cell
How to uncoat
Cellular Defense systems
How to deal with Actin: actin remodelling
How to get to site of replication
How to mimic cellular mRNAs
Eukaryotic translation only monocistronic mRNA
Viral and cellular mRNA are in competition for translation machinery
Initiating genome replication
Replicating the ends of the genome
Packaging the genome
How to get out of the cell
The host's immune response
True or False: All large DNA viruses (>50 kb) are enveloped
Give this one a try later!
TRUE
[Pox and Herpes are the only two that are more than 50kb]
What Starts DNA Replication: for Polyoma, Papilloma, and Herpes?
