What is lactoferrin?
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binds to iron, which creases the availability
What is anemia of chronic inflammation?
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Caused by underlying conditions like malignancies or RA. Causes
inflammatory cytokine production
What specialized tests is used for IDA?
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evaluation of heme synthesis, free erythrocyte protoporphyrin, sTfR
What is stage 1 IDA?
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Progressive loss of storage of iron
What are the symptoms of aplastic anemia?
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severe anemia, neutropenia, hypocellular BM, slow onset, tachycardia,
cardiac failure, fever (due to neutropenia), bleeding.
What is Pernicious Anemia?
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Caused by impaired absorption of cobalamin due to the lack of the intrinsic
factor . It causes decreased cobalamin absorption
Serum iron normal value
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50-160 ug/dL
What is EMA binding test
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uses Eosin-5'-maleimide, a fluorescent dye that binds to band 3, RhAg,
CD47. HS patients demonstrate low mean fluorescence intensity.
What are dietary sources of iron?
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Red meat, legumes ,dark leafy vegetables, whole grain
Where do spur cell anemia hemolyze and what does it cause?
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In the spleen which causes spleomegaly, jaundice and anemia
What are sTfR's stand for?
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Soluble transferrin receptors
What are megaloblastic lab findings?
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CBC (decreased H:H, macrocytosis (mega-), MCV 100-150 fL, high RDW),
low retic count (ineffective erythropoiesis) causing pancytopenia.
Increased lactate dehydrogenase, inc total and indirect bilirubin, nuclear-
cytoplasmic asynchrony most striking at the polychromatic normoblast
stage
How does iron distribution?
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mature RBCs (2500 mg), liver (1000 mg), macrophages (600 mg), BM (300
mg), myoglobin (300 mg), transferrin (4 mg), duodenum (1-2 mg)
Give this one a try later!
binds to iron, which creases the availability
What is anemia of chronic inflammation?
,Give this one a try later!
Caused by underlying conditions like malignancies or RA. Causes
inflammatory cytokine production
What specialized tests is used for IDA?
Give this one a try later!
evaluation of heme synthesis, free erythrocyte protoporphyrin, sTfR
What is stage 1 IDA?
Give this one a try later!
Progressive loss of storage of iron
What are the symptoms of aplastic anemia?
Give this one a try later!
severe anemia, neutropenia, hypocellular BM, slow onset, tachycardia,
cardiac failure, fever (due to neutropenia), bleeding.
What is Pernicious Anemia?
,Give this one a try later!
Caused by impaired absorption of cobalamin due to the lack of the intrinsic
factor . It causes decreased cobalamin absorption
Serum iron normal value
Give this one a try later!
50-160 ug/dL
What is EMA binding test
Give this one a try later!
uses Eosin-5'-maleimide, a fluorescent dye that binds to band 3, RhAg,
CD47. HS patients demonstrate low mean fluorescence intensity.
What are dietary sources of iron?
Give this one a try later!
Red meat, legumes ,dark leafy vegetables, whole grain
Where do spur cell anemia hemolyze and what does it cause?
, Give this one a try later!
In the spleen which causes spleomegaly, jaundice and anemia
What are sTfR's stand for?
Give this one a try later!
Soluble transferrin receptors
What are megaloblastic lab findings?
Give this one a try later!
CBC (decreased H:H, macrocytosis (mega-), MCV 100-150 fL, high RDW),
low retic count (ineffective erythropoiesis) causing pancytopenia.
Increased lactate dehydrogenase, inc total and indirect bilirubin, nuclear-
cytoplasmic asynchrony most striking at the polychromatic normoblast
stage
How does iron distribution?
Give this one a try later!
mature RBCs (2500 mg), liver (1000 mg), macrophages (600 mg), BM (300
mg), myoglobin (300 mg), transferrin (4 mg), duodenum (1-2 mg)
