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Hypersensitivity

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[organism name], [disease name], microbiology nursing notes, [gram reaction], [toxin name], pathogenesis, clinical features, laboratory diagnosis, treatment, prevention, [university name], BS Nursing, [semester], lecture notes, exam preparation

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RIPHAH INTERNATIONAL UNIVERSITY
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·Fundamentals of Nursing · English & Communication (MARIA78461)

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H yper sensitivity - II
Pr of. Dr Shahina Y asm in

,
, Type III Immune complex hypersensitivity
• IgG mediated - Immune complexes are removed from
circulation by reticulo-endothelial system.
• In persistent viral & bacterial infections, immune
complexes persist, deposit in tissues - complement
activation - induce an inflammatory response, mediators
increase vascular permeability, attract neutrophils, intra-
vascular clumping of platelets leading to vascular
occlusion, cause tissue damage and necrosis.
• Autoimmune diseases, antibodies produced against self
antigens, intermediate and small size antigen-antibody
complexes deposited in tissues like kidneys (nephritis),
joints (arthritis), blood vessels (vasculitis)
• Exam ples: Arthus reaction, Serum sickness
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RIPHAH INTERNATIONAL UNIVERSITY
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·Fundamentals of Nursing · English & Communication (MARIA78461)
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Number of pages
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Written in
2025/2026
Type
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Professor doctor shahina yasmin
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Subjects

  • microbiology
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