Bacterial Pathogenesis II
Prof Shahina Yasmin
, LOs
• Explain the role of various virulence factors of
bacteria in pathogenesis.
• Compare the various aspects of endotoxin and
exotoxins
• Explain the mechanism of immuno-pathogenesis
• Explain the typical stages of an infectious disease
, Virulence factors
• Structures, substances or mechanisms by virtue of
which an organism is able to produce disease
1. Bacterial structures: capsule, glycocalyx, pili, fimbrae,
surface proteins, invasin, yops, M protein, Protein A,
curli
2. Enzymes: Streptokinase, Collagenase, Hyaluronidase,
Lecithenase, DNAase, Coagulase, IgA Protease, Catalase,
Leucocidins
3. Intracellular survival
4. Toxin production
Prof Shahina Yasmin
, LOs
• Explain the role of various virulence factors of
bacteria in pathogenesis.
• Compare the various aspects of endotoxin and
exotoxins
• Explain the mechanism of immuno-pathogenesis
• Explain the typical stages of an infectious disease
, Virulence factors
• Structures, substances or mechanisms by virtue of
which an organism is able to produce disease
1. Bacterial structures: capsule, glycocalyx, pili, fimbrae,
surface proteins, invasin, yops, M protein, Protein A,
curli
2. Enzymes: Streptokinase, Collagenase, Hyaluronidase,
Lecithenase, DNAase, Coagulase, IgA Protease, Catalase,
Leucocidins
3. Intracellular survival
4. Toxin production
