polycythemia vera (PV)
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-etiology: neoplastic clonal stem cells mature independently of EPO
stimulation, causing panmyelosis with a predominate increase in
erythrocytes (grans and PLTs can be increased too)
-Chromosomal abnormality: JAK2V617F mutation
-morphology: N/N RBCs, teardrop cells (dacrocytes) present
-symptoms: triad of BM fibrosis, splenomegaly and anemia w/ teardrop
cells (dacrocytes)
-lab findings: Hgb/ Hct/ RCM increased, low serum EPO levels
, -PB: RBCs increased, total WBCs increased, granulocytes increased, PLTs
increased, LAP stain normal to inc.
-BM: hypercellular, normoblasts (immature RBCs) increased, granulocytes
increased, megakaryocytes increased, reticulin fibers increased
therapy-related MDS (T-MDS)
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medical treatment (chemotherapy, radiation therapy) leads to
myelodysplastic syndromes 4-7 years after treatment
-therapies introduce mutations into cell lines and apply selective pressure
on cells of the BM to allow mutations to accumulate
-more aggressive than De Novo MDS
-transitions into AML
chronic myeloid leukemia (CML) treatments
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-BM transplant or SCT= CURE
-gleevec (imatnib mesylate)
-sprycel, dasigna, bosulib, iclusig
polycythemia vera (PV) chromosomal abnormality
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, JAK2V617F mutation (most cases)
myeloproliferative meoplasms (MPN)
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clonal hematopoietic disorders caused by genetic mutations in
hematopoietic stem cells taht cause expansion, excess production and
accumulation of the cell lines (erythrocytes, granulocytes and platelets)
-each MPN is characterized by the clonal expansion or one or more
specific cell lines
fibrosis of bone marrow (PMF)
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increased Platelet Derived Growth Factor (PDGF) leads to increased
collagen and reticulin fiber synthesis
-increased collagen and reticulin fibers in the bone marrow= fibrosis of the
bone marrow
MDS-U defining cytogenetic abnormality (MDS unclassifiable with defining
cytogenetic abnormality)
Give this one a try later!
Give this one a try later!
-etiology: neoplastic clonal stem cells mature independently of EPO
stimulation, causing panmyelosis with a predominate increase in
erythrocytes (grans and PLTs can be increased too)
-Chromosomal abnormality: JAK2V617F mutation
-morphology: N/N RBCs, teardrop cells (dacrocytes) present
-symptoms: triad of BM fibrosis, splenomegaly and anemia w/ teardrop
cells (dacrocytes)
-lab findings: Hgb/ Hct/ RCM increased, low serum EPO levels
, -PB: RBCs increased, total WBCs increased, granulocytes increased, PLTs
increased, LAP stain normal to inc.
-BM: hypercellular, normoblasts (immature RBCs) increased, granulocytes
increased, megakaryocytes increased, reticulin fibers increased
therapy-related MDS (T-MDS)
Give this one a try later!
medical treatment (chemotherapy, radiation therapy) leads to
myelodysplastic syndromes 4-7 years after treatment
-therapies introduce mutations into cell lines and apply selective pressure
on cells of the BM to allow mutations to accumulate
-more aggressive than De Novo MDS
-transitions into AML
chronic myeloid leukemia (CML) treatments
Give this one a try later!
-BM transplant or SCT= CURE
-gleevec (imatnib mesylate)
-sprycel, dasigna, bosulib, iclusig
polycythemia vera (PV) chromosomal abnormality
Give this one a try later!
, JAK2V617F mutation (most cases)
myeloproliferative meoplasms (MPN)
Give this one a try later!
clonal hematopoietic disorders caused by genetic mutations in
hematopoietic stem cells taht cause expansion, excess production and
accumulation of the cell lines (erythrocytes, granulocytes and platelets)
-each MPN is characterized by the clonal expansion or one or more
specific cell lines
fibrosis of bone marrow (PMF)
Give this one a try later!
increased Platelet Derived Growth Factor (PDGF) leads to increased
collagen and reticulin fiber synthesis
-increased collagen and reticulin fibers in the bone marrow= fibrosis of the
bone marrow
MDS-U defining cytogenetic abnormality (MDS unclassifiable with defining
cytogenetic abnormality)
Give this one a try later!
