STEP 1 USMLE | Updated most Frequent Tested Exam 2026
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Leukocyte Adhesion Deficiency (LAD) -ANSWERS-immune deficiency caused by
defects in leukocyte function: failure in adhesion defect in CD 18 containing integrins
Skin& mucosal infections w/o pus
Impaired wound healing
Delayed umbilical cord separation
Leukocytosis and neutrophilia
Serotonin syndrome -ANSWERS-With any drug that increases 5-HT (e.g., MAO
inhibitors, SNRIs, TCAs) hyperthermia, confusion, myoclonus, cardiovascular instability,
flushing, diarrhea, seizures.
-Treatment: cyproheptadine (5-HT2 receptor antagonist).
Splenic laceration -ANSWERS-Left shoulder pain(referred pain Kerh sign) hypotension,
tachycardia
Phrenic nerve C3-C5. (Hiccups-spasmodic diaphragmatic contraction pulling air against
a close larynx)
Bupropion (Wellbutrin) -ANSWERS-Antidepressant
Inhibit reputare of NE & dopamine
No weight gain or sexual desire effect
Seizures in high doses
Contraindicated in Seizures & bulimia o anorexia
, Ototoxicity -ANSWERS-loop diuretics
Spironolactone (Aldactone) -ANSWERS-potassium-sparing diuretic; aldosterone
antagonist
Distal and collecting duct
Side effects: hyperkalemia, gynecomastia, impotence, and decreased libido
Hydroclorothiazide -ANSWERS-thiazide diuretic
Hypokalemia
Hyponatremia
Hypomagnesemia
Hypercalcemia
Ubiquination of proteins -ANSWERS-is a covalent post-translational modification of
proteins.
Targets a protein for proteasomal destruction, lowering its half life, lowering its
abundance
Genomic imprinting is generally due to the addition of methyl (-CH3) groups to C
nucleotides in order to silence a given gene. If this depends on the sex of the parent
who transmits the gene, which of the following must be true? -ANSWERS-Caused by
DNA methylation
An epigenetic process in which genes can be silenced by attaching methyl groups to
cytosine in the DNA molecule
Primary adrenal insufficiency
Adison's disease -ANSWERS-Abdominal pain
Weight loss
Salt cravings
Orthostasis
WITH Recent Newest Verified And Well Analyzed Exam
Questions (Actual Exam 2026-2027) Correct Detailed &
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Pass!!
Leukocyte Adhesion Deficiency (LAD) -ANSWERS-immune deficiency caused by
defects in leukocyte function: failure in adhesion defect in CD 18 containing integrins
Skin& mucosal infections w/o pus
Impaired wound healing
Delayed umbilical cord separation
Leukocytosis and neutrophilia
Serotonin syndrome -ANSWERS-With any drug that increases 5-HT (e.g., MAO
inhibitors, SNRIs, TCAs) hyperthermia, confusion, myoclonus, cardiovascular instability,
flushing, diarrhea, seizures.
-Treatment: cyproheptadine (5-HT2 receptor antagonist).
Splenic laceration -ANSWERS-Left shoulder pain(referred pain Kerh sign) hypotension,
tachycardia
Phrenic nerve C3-C5. (Hiccups-spasmodic diaphragmatic contraction pulling air against
a close larynx)
Bupropion (Wellbutrin) -ANSWERS-Antidepressant
Inhibit reputare of NE & dopamine
No weight gain or sexual desire effect
Seizures in high doses
Contraindicated in Seizures & bulimia o anorexia
, Ototoxicity -ANSWERS-loop diuretics
Spironolactone (Aldactone) -ANSWERS-potassium-sparing diuretic; aldosterone
antagonist
Distal and collecting duct
Side effects: hyperkalemia, gynecomastia, impotence, and decreased libido
Hydroclorothiazide -ANSWERS-thiazide diuretic
Hypokalemia
Hyponatremia
Hypomagnesemia
Hypercalcemia
Ubiquination of proteins -ANSWERS-is a covalent post-translational modification of
proteins.
Targets a protein for proteasomal destruction, lowering its half life, lowering its
abundance
Genomic imprinting is generally due to the addition of methyl (-CH3) groups to C
nucleotides in order to silence a given gene. If this depends on the sex of the parent
who transmits the gene, which of the following must be true? -ANSWERS-Caused by
DNA methylation
An epigenetic process in which genes can be silenced by attaching methyl groups to
cytosine in the DNA molecule
Primary adrenal insufficiency
Adison's disease -ANSWERS-Abdominal pain
Weight loss
Salt cravings
Orthostasis
