NSG 533 Advanced Pharmacology | Exam 1 |
Verified Questions and Answers | Final Exam
Prep | 2026/2027
• Which drug class is most effective in treating erosive lesions:? -✓✓PPIs
• Name 4 H2RAs: -✓✓Cimetidine (Tagamet)
Famotidine (Pepcid)
Ranitidine (Zantac)
Nizatidine (Axid)
• What is the action of H2RAs? -✓✓Decrease acid secretion by blocking histamine
2-receptors in gastric parietal cells
• Name 4 benefits of H2RAs -✓✓1. Relieve GERD symptoms
2. Can be administered prophylactically
3. More effective at controlling chronic GERD symptoms than ANTACIDS
4. Intermittent & routine dosing possible based on degree of symptom control
needed.
• Name 2 drawbacks of H2RAs -✓✓1. Less effective in controlling chronic GERD
symptoms than PPIs
2. Renal elimination may require dose adjustment in kidney dysfunction patients
• What are the side effects associated with H2RAs? -✓✓H/A, nausea (Cimetidine),
weak inhibitor, common drug interactions, gynecomastia, & Vit B-12 deficiency
which affects patients' tolerance
• Name the benefits of Antacids -✓✓1. Useful for intermittent treatment of GERD
symptoms
2. Immediate symptom relief
3. Usually well-tolerated
• What are the drawbacks of Antacids? -✓✓1. Requires frequent dosing
2. Aluminum or Magnesium containing antacids may result in electrolyte
imbalances esp. in pts. w/renal impairment
, 3. May interfere w/absorption of fluoroquinolones, tetracyclines, iron products, &
thyroid hormones
(doses should be several hours apart)
• What are the side effects of Antacids? -✓✓May cause
Constipation or Diarrhea depending on the formulation used
• What is the Pharmacological Therapy Effectiveness of Antacids? -✓✓Antacids
briefly neutralize gastric acid but lacks acid-suppressive properties & are inferior
to H2RAs
• What is the Pharmacological Therapy Effectiveness of H2RAs? -✓✓Histamine-2
Receptor Antagonists decrease acid secretion to a lesser extent than PPIs (& are
therefore inferior to PPIs)
• What is the Pharmacological Therapy Effectiveness of PPIs? -✓✓Proton Pump
Inhibitors block the rate-limiting step in acid secretion from gastric parietal cells &
block all pathways for gastric acid secretion & therefore are better than H2RAs
• What is the treatment goal of pharmacological therapy in GERD? -✓✓Increase
the pH of gastric content by; 1) Direct gastric acid neutralization 2) Reduce acid
production through inhibiting the stimulation of pathways to decrease GERD
symptoms and prevent tissue damage
• Which Bariatric Surgery is effective in reducing GERD symptoms in obese
patients? -✓✓Roux-en-Y gastric bypass
• Which Bariatric Surgery is ineffective in reducing GERD symptoms in obese
patients? -✓✓Vertical banded gastroplasty
• Which is more beneficial in esophagitis symptom control; Omeprazole or
Antireflux surgery? -✓✓In a 7-year follow-up study, Antireflux surgery provided
more symptom control in esophagitis patients
• Name 4 Factors indicating when Antireflux Surgery is an appropriate option for
patients w/well documented GERD: -✓✓1) S/Es are intolerable/undesired
2) Adherence is a challenge
3) Large Hiatal Hernia is present
Verified Questions and Answers | Final Exam
Prep | 2026/2027
• Which drug class is most effective in treating erosive lesions:? -✓✓PPIs
• Name 4 H2RAs: -✓✓Cimetidine (Tagamet)
Famotidine (Pepcid)
Ranitidine (Zantac)
Nizatidine (Axid)
• What is the action of H2RAs? -✓✓Decrease acid secretion by blocking histamine
2-receptors in gastric parietal cells
• Name 4 benefits of H2RAs -✓✓1. Relieve GERD symptoms
2. Can be administered prophylactically
3. More effective at controlling chronic GERD symptoms than ANTACIDS
4. Intermittent & routine dosing possible based on degree of symptom control
needed.
• Name 2 drawbacks of H2RAs -✓✓1. Less effective in controlling chronic GERD
symptoms than PPIs
2. Renal elimination may require dose adjustment in kidney dysfunction patients
• What are the side effects associated with H2RAs? -✓✓H/A, nausea (Cimetidine),
weak inhibitor, common drug interactions, gynecomastia, & Vit B-12 deficiency
which affects patients' tolerance
• Name the benefits of Antacids -✓✓1. Useful for intermittent treatment of GERD
symptoms
2. Immediate symptom relief
3. Usually well-tolerated
• What are the drawbacks of Antacids? -✓✓1. Requires frequent dosing
2. Aluminum or Magnesium containing antacids may result in electrolyte
imbalances esp. in pts. w/renal impairment
, 3. May interfere w/absorption of fluoroquinolones, tetracyclines, iron products, &
thyroid hormones
(doses should be several hours apart)
• What are the side effects of Antacids? -✓✓May cause
Constipation or Diarrhea depending on the formulation used
• What is the Pharmacological Therapy Effectiveness of Antacids? -✓✓Antacids
briefly neutralize gastric acid but lacks acid-suppressive properties & are inferior
to H2RAs
• What is the Pharmacological Therapy Effectiveness of H2RAs? -✓✓Histamine-2
Receptor Antagonists decrease acid secretion to a lesser extent than PPIs (& are
therefore inferior to PPIs)
• What is the Pharmacological Therapy Effectiveness of PPIs? -✓✓Proton Pump
Inhibitors block the rate-limiting step in acid secretion from gastric parietal cells &
block all pathways for gastric acid secretion & therefore are better than H2RAs
• What is the treatment goal of pharmacological therapy in GERD? -✓✓Increase
the pH of gastric content by; 1) Direct gastric acid neutralization 2) Reduce acid
production through inhibiting the stimulation of pathways to decrease GERD
symptoms and prevent tissue damage
• Which Bariatric Surgery is effective in reducing GERD symptoms in obese
patients? -✓✓Roux-en-Y gastric bypass
• Which Bariatric Surgery is ineffective in reducing GERD symptoms in obese
patients? -✓✓Vertical banded gastroplasty
• Which is more beneficial in esophagitis symptom control; Omeprazole or
Antireflux surgery? -✓✓In a 7-year follow-up study, Antireflux surgery provided
more symptom control in esophagitis patients
• Name 4 Factors indicating when Antireflux Surgery is an appropriate option for
patients w/well documented GERD: -✓✓1) S/Es are intolerable/undesired
2) Adherence is a challenge
3) Large Hiatal Hernia is present
