ARF, Lung Cancer | Q&A | Grade A | 100% Correct (Verified Answers) –
Nursing Program
Subject: Endocrine Disorders (Thyroid, SIADH, DI) & Respiratory Failure (ARDS, ARF, Lung Cancer,
Pneumothorax)
Source: NSG-430 Exam 1 Bank – Latest 2026/2027 Curriculum
Format: Q&A Guide with Clinical Rationale
Total Questions: 98 (All processed – no omissions)
1: What medication increases thyroid hormone?
Correct Answer: Aspirin
1. Aspirin at high doses can displace thyroid hormones from binding proteins, increasing free T3/T4 levels.
2. This effect is clinically relevant in patients on thyroid replacement; close monitoring is required.
2: What are anti-thyroid medications?
Correct Answer: PTU, methimazole
1. Propylthiouracil (PTU) and methimazole inhibit thyroid peroxidase, reducing thyroid hormone synthesis.
2. PTU also blocks peripheral conversion of T4 to T3.
3: Which anti-thyroid medication can be given during the first trimester of pregnancy?
Correct Answer: PTU
1. PTU is preferred in the first trimester due to lower risk of teratogenic effects compared to methimazole.
2. After the first trimester, patients may switch to methimazole due to PTU's hepatotoxicity risk.
4: What organ can be damaged by PTU (propylthiouracil)?
Correct Answer: Liver
1. PTU carries a black box warning for severe hepatotoxicity, including liver failure and death.
2. Patients should be monitored for jaundice, dark urine, and elevated LFTs.
5: What are two adverse effects of anti-thyroid medications?
Correct Answer: agranulocytosis, thrombocytopenia
1. Agranulocytosis (fever, sore throat) is a rare but life-threatening reaction requiring prompt discontinuation.
2. Thrombocytopenia can also occur; monitor CBC regularly during therapy.
6: What medication blocks the secretion of thyroid hormones?
Correct Answer: Iodine "Lugol's" solution
1. Lugol's solution inhibits thyroid hormone release by blocking thyroglobulin proteolysis.
2. It is used preoperatively for thyroidectomy and in thyroid storm after antithyroid drugs.
, 7: What medication prevents the conversion of thyroid hormones (T4 to T3)?
Correct Answer: dexamethasone
1. Dexamethasone inhibits peripheral conversion of T4 to active T3, used in thyroid storm management.
2. This effect is dose-dependent and occurs within hours of administration.
8: What drug class is dexamethasone?
Correct Answer: glucocorticoid
1. Dexamethasone is a potent long-acting glucocorticoid with anti-inflammatory and immunosuppressant
properties.
2. It also suppresses ACTH release and has mineralocorticoid activity.
9: What is a side effect of Lugol's solution (iodine)?
Correct Answer: metallic taste
1. Metallic taste (dysgeusia) is a common and benign side effect of iodine solutions.
2. Other side effects include burning mouth, increased salivation, and GI upset.
10: What medication inhibits thyroid secretion?
Correct Answer: lithium
1. Lithium inhibits thyroid hormone release and can cause hypothyroidism or goiter in long-term use.
2. Thyroid function should be monitored regularly in patients taking lithium.
11: What are the signs and symptoms of hyponatremia?
Correct Answer: seizures, headache, vomiting, decreased neurologic function
1. Neurologic symptoms dominate due to cerebral edema from osmotic fluid shift.
2. Severity correlates with rapidity of onset; chronic hyponatremia may be asymptomatic or mild.
12: What does the sodium level need to be to administer furosemide?
Correct Answer: 125 or greater
1. Furosemide can worsen hyponatremia; it is generally avoided when Na <125 mEq/L.
2. Loop diuretics are used cautiously in SIADH only after careful risk-benefit analysis.
13: What does demeclocycline do?
Correct Answer: blocks the effect of ADH
1. Demeclocycline induces nephrogenic diabetes insipidus by antagonizing ADH at the collecting duct.
2. It is used in chronic SIADH when fluid restriction fails.
14: At what sodium level would 3% sodium chloride be given?
Correct Answer: 120 mEq/L
1. Severe symptomatic hyponatremia (Na <120 with seizures) requires hypertonic saline.
2. Administer in ICU with close neurologic and electrolyte monitoring.