LEHNES PHARMACOTHERAPEUTICS
ADVANCED PRACTICE NURSES PHYSICIAN
ASSISTANTS THIRD EDITION EXAM SET
CHAPTERS ONE TO LAST 2026 SOLUTIONS
REVIEW GRADED A+
⩥Drugs do not metabolize the same way in all people. For what patient
would a nurse expect to assess for an alteration in drug metabolism?
A) A 35-year-old woman with cervical cancer
B) A 41-year-old man with kidney stones
C) A 50-year-old man with cirrhosis of the liver
D) A 62-year-old woman in acute renal failure.
Answer: Ans: C
Feedback:
The liver is the most important site of drug metabolism. If the liver is not
functioning effectively, as in patients with cirrhosis, drugs will not
metabolize normally so that toxic
levels could develop unless dosage is reduced. A patient with cervical
cancer or kidney stones would not be expected to have altered ability to
metabolize drugs so long as no liver
,damage existed. The patient with renal failure would have altered
excretion of the drugs through the renal system but metabolism would
not be impacted
⩥A patient presents to the emergency department with a drug level of 50
units/mL. The half-life of this drug is 1 hour. With this drug,
concentrations above 25 units/mL are considered toxic and no more drug
is given. How long will it take for the blood level to reach the non-toxic
range?
A) 30 minutes
B) 1 hour
C) 2 hours
D) 3 hours.
Answer: Ans: B
Feedback:
Half-life is the time required for the serum concentration of a drug to
decrease by 50%. After 1 hour, the serum concentration would be 25
units/mL (50/2) if the body can
properly metabolize and excrete the drug. After 2 hours, the serum
concentration would be 12.5 units/mL (25/2) and reach the nontoxic
range. In 30 minutes the drug level would
be 37.5 units/mL, whereas in 3 hours the drug level would be 6.25.
,⩥A patient has recently moved from Vermont to Southern Florida. The
patient presents to
the clinic complaining of dizzy spells and weakness. While conducting
the admission assessment, the patient tells the nurse that he have been on
the same antihypertensive drug for 6 years and had stable blood
pressures and no adverse effects. Since his move, he has been having
problems and he feels that the drug is no longer effective. The clinic
nurse
knows that one possible reason for the change in the effectiveness of the
drug could be what?
A) The impact of the placebo effect on the patients response.
B) The accumulative effect of the drug if it has been taken for many
years.
C) The impact of the warmer environment on the patients physical
status.
D) Problems with patient compliance with the drug regimen while on
vacation..
Answer: Ans: C
Feedback: Antihypertensive drugs work to decrease the blood pressure.
When a patient goes to a climate that is much warmer than usual, blood
vessels dilate and the blood pressure falls. If a patient is taking an
antihypertensive drug and movesto a warmer climate, there is a chance
that the patients blood pressure will drop too low, resulting in dizziness
and feelings of weakness. Even mild dehydration could exacerbate these
effects. Most antihypertensives are metabolized and excreted and do not
accumulate in the body. Patients must be very compliant with their drug
, regimen on vacation. After several years on an antihypertensive drug,
the effects of that drug are known; therefore, the placebo effect should
not be an issue.
⩥An important concept taught by the nurse when providing medication
teaching is the need to provide a complete list of medications taken to
health care providers to avoid what?
A) Spending large amounts of money on medications B) Allergic
reactions to medications
C) Drugdrug interactions
D) Critical concentrations of medications in the body.
Answer: Ans: C
Feedback: It is important that all health care providers have a complete
list of the patients medications to avoid drugdrug interactions caused by
one provider ordering a medication, unaware of another medication the
patient is taking that could interact with the new prescription. Using the
same pharmacist for all prescriptions will also help to prevent this from
happening. Informing the provider of all medications taken will not
reduce costs of medications, which is best accomplished by requesting
generic medications. Allergies should be disclosed to all health care
providers as well, but this is not why it is important to provide a
complete list of medications taken. Critical concentrations are desirable
because that is the amount of drug needed to cause a therapeutic effect,
or, in other words, to have the effect the drug is prescribed for.
ADVANCED PRACTICE NURSES PHYSICIAN
ASSISTANTS THIRD EDITION EXAM SET
CHAPTERS ONE TO LAST 2026 SOLUTIONS
REVIEW GRADED A+
⩥Drugs do not metabolize the same way in all people. For what patient
would a nurse expect to assess for an alteration in drug metabolism?
A) A 35-year-old woman with cervical cancer
B) A 41-year-old man with kidney stones
C) A 50-year-old man with cirrhosis of the liver
D) A 62-year-old woman in acute renal failure.
Answer: Ans: C
Feedback:
The liver is the most important site of drug metabolism. If the liver is not
functioning effectively, as in patients with cirrhosis, drugs will not
metabolize normally so that toxic
levels could develop unless dosage is reduced. A patient with cervical
cancer or kidney stones would not be expected to have altered ability to
metabolize drugs so long as no liver
,damage existed. The patient with renal failure would have altered
excretion of the drugs through the renal system but metabolism would
not be impacted
⩥A patient presents to the emergency department with a drug level of 50
units/mL. The half-life of this drug is 1 hour. With this drug,
concentrations above 25 units/mL are considered toxic and no more drug
is given. How long will it take for the blood level to reach the non-toxic
range?
A) 30 minutes
B) 1 hour
C) 2 hours
D) 3 hours.
Answer: Ans: B
Feedback:
Half-life is the time required for the serum concentration of a drug to
decrease by 50%. After 1 hour, the serum concentration would be 25
units/mL (50/2) if the body can
properly metabolize and excrete the drug. After 2 hours, the serum
concentration would be 12.5 units/mL (25/2) and reach the nontoxic
range. In 30 minutes the drug level would
be 37.5 units/mL, whereas in 3 hours the drug level would be 6.25.
,⩥A patient has recently moved from Vermont to Southern Florida. The
patient presents to
the clinic complaining of dizzy spells and weakness. While conducting
the admission assessment, the patient tells the nurse that he have been on
the same antihypertensive drug for 6 years and had stable blood
pressures and no adverse effects. Since his move, he has been having
problems and he feels that the drug is no longer effective. The clinic
nurse
knows that one possible reason for the change in the effectiveness of the
drug could be what?
A) The impact of the placebo effect on the patients response.
B) The accumulative effect of the drug if it has been taken for many
years.
C) The impact of the warmer environment on the patients physical
status.
D) Problems with patient compliance with the drug regimen while on
vacation..
Answer: Ans: C
Feedback: Antihypertensive drugs work to decrease the blood pressure.
When a patient goes to a climate that is much warmer than usual, blood
vessels dilate and the blood pressure falls. If a patient is taking an
antihypertensive drug and movesto a warmer climate, there is a chance
that the patients blood pressure will drop too low, resulting in dizziness
and feelings of weakness. Even mild dehydration could exacerbate these
effects. Most antihypertensives are metabolized and excreted and do not
accumulate in the body. Patients must be very compliant with their drug
, regimen on vacation. After several years on an antihypertensive drug,
the effects of that drug are known; therefore, the placebo effect should
not be an issue.
⩥An important concept taught by the nurse when providing medication
teaching is the need to provide a complete list of medications taken to
health care providers to avoid what?
A) Spending large amounts of money on medications B) Allergic
reactions to medications
C) Drugdrug interactions
D) Critical concentrations of medications in the body.
Answer: Ans: C
Feedback: It is important that all health care providers have a complete
list of the patients medications to avoid drugdrug interactions caused by
one provider ordering a medication, unaware of another medication the
patient is taking that could interact with the new prescription. Using the
same pharmacist for all prescriptions will also help to prevent this from
happening. Informing the provider of all medications taken will not
reduce costs of medications, which is best accomplished by requesting
generic medications. Allergies should be disclosed to all health care
providers as well, but this is not why it is important to provide a
complete list of medications taken. Critical concentrations are desirable
because that is the amount of drug needed to cause a therapeutic effect,
or, in other words, to have the effect the drug is prescribed for.
