MICB 4131 EXAM 2 QUESTIONS WITH VERFIED SOLUTIONS LATEST UPDATE 2026
IL-1 - Answers induction of inflammation
IL-2 - Answers secreted by T Cells, promotes B, T, NK and AICD proliferation
IL-4 - Answers secreted by TH2 cells, promotes differentiation of T to TH2 cells and isotype switch to
IgE
IL-5 - Answers secreted by TH2, activates and generates eosinophils
IL-7 - Answers made by stromal cells, are required for survival of naive T and B cells
IL-15 - Answers required for memory T cell survival
TNF-a - Answers secreted by macrophages, causes inflammation and induces cell death
IFN-b - Answers secreted by all nucleated cells, induces antiviral state and MHC I expression
IFN-g - Answers secreted by TH1, CD8 and NK cells, activates macrophages, increases antigen
presentation and expression of MHC I and MHC II
TGF-b - Answers secreted by T cells and macrophages, inhibits T cell and B cell proliferation,
promotes isotype switch to IgA
CD44 - Answers Cell adhesion molecule, expressed in memory and effector T cells
CD26L - Answers receptor for homing to lymph node
CCR7 - Answers chemokine receptor for homing in naive B and T cells, binding CCL21 and CCL19
produced by DC
BCL-2 - Answers promotes cell survival
granzyme B - Answers (2/2) effector molecule in cell killing by T cells
FasL - Answers (1/2) effector molecule in cell killing by T cells
CD122 - Answers part of receptor for IL-15 and IL-2
CD25 - Answers part of receptor for IL-2
CD127 - Answers part of receptor for IL-7
JAKs - Answers kinase that are activated by cytokine
STATs - Answers transcription factor part of the cytokine induced signal transduction pathway
CD40L - Answers surface molecule of helper T cells that drives B cell activation
CD40 - Answers surface molecule of B cells, that upon stimuli from T cells drive B cell activation
IgM - Answers present on naive B cells, first Ab secreted, usually as a pentamer
IgD - Answers present on naive B cells, but not secreted
IgA - Answers secreted as a dimer
IgE - Answers prebound to mast cells, usually not circulating
CD19 - Answers part of the BCR co-receptor, crucial signaling molecule
CR2 - Answers part of the BCR co-receptor, complement receptor
CD81 - Answers part of the BCER co-receptor, unknown function
Rag-1 and Rag-2 - Answers lymphoid specific recombinase, part of Ab rearrangement
L5 and VpreB - Answers components of Ab surrogate light chain
Pax-5 - Answers transcription factor
CCL21 and CCL19 - Answers cytokines produced by DC, ligands for CCR7 in naive B and T cells
CXCL13 - Answers cytokine from DC that attracts immature B cells through CXCR5
CXCR5 - Answers receptor for CXCL13 in immature B cells, causing their attraction to DCs
DSBR - Answers V(D)J recombinase responsible for ds break repair
RAG - Answers V(D)J recombinase responsible for gene activation
TdT - Answers V(D)J recombinase responsible for terminal deoxynucleotidyl transfer
B7 - Answers co-stimulatory molecule in DCs that bind naive T cells (signal 2)
CD28 - Answers naive T cell receptor for signal 2
ITAM - Answers phosphorylated during TCR/MHC binding
ZAP-70 - Answers binds phosphorylated ITAM, activating Lck
L-selectin - Answers interrupted upon T-cell activation
LFA-1 and CD44 - Answers over-expressed upon T-cell activation
IL-1 - Answers induction of inflammation
IL-2 - Answers secreted by T Cells, promotes B, T, NK and AICD proliferation
IL-4 - Answers secreted by TH2 cells, promotes differentiation of T to TH2 cells and isotype switch to
IgE
IL-5 - Answers secreted by TH2, activates and generates eosinophils
IL-7 - Answers made by stromal cells, are required for survival of naive T and B cells
IL-15 - Answers required for memory T cell survival
TNF-a - Answers secreted by macrophages, causes inflammation and induces cell death
IFN-b - Answers secreted by all nucleated cells, induces antiviral state and MHC I expression
IFN-g - Answers secreted by TH1, CD8 and NK cells, activates macrophages, increases antigen
presentation and expression of MHC I and MHC II
TGF-b - Answers secreted by T cells and macrophages, inhibits T cell and B cell proliferation,
promotes isotype switch to IgA
CD44 - Answers Cell adhesion molecule, expressed in memory and effector T cells
CD26L - Answers receptor for homing to lymph node
CCR7 - Answers chemokine receptor for homing in naive B and T cells, binding CCL21 and CCL19
produced by DC
BCL-2 - Answers promotes cell survival
granzyme B - Answers (2/2) effector molecule in cell killing by T cells
FasL - Answers (1/2) effector molecule in cell killing by T cells
CD122 - Answers part of receptor for IL-15 and IL-2
CD25 - Answers part of receptor for IL-2
CD127 - Answers part of receptor for IL-7
JAKs - Answers kinase that are activated by cytokine
STATs - Answers transcription factor part of the cytokine induced signal transduction pathway
CD40L - Answers surface molecule of helper T cells that drives B cell activation
CD40 - Answers surface molecule of B cells, that upon stimuli from T cells drive B cell activation
IgM - Answers present on naive B cells, first Ab secreted, usually as a pentamer
IgD - Answers present on naive B cells, but not secreted
IgA - Answers secreted as a dimer
IgE - Answers prebound to mast cells, usually not circulating
CD19 - Answers part of the BCR co-receptor, crucial signaling molecule
CR2 - Answers part of the BCR co-receptor, complement receptor
CD81 - Answers part of the BCER co-receptor, unknown function
Rag-1 and Rag-2 - Answers lymphoid specific recombinase, part of Ab rearrangement
L5 and VpreB - Answers components of Ab surrogate light chain
Pax-5 - Answers transcription factor
CCL21 and CCL19 - Answers cytokines produced by DC, ligands for CCR7 in naive B and T cells
CXCL13 - Answers cytokine from DC that attracts immature B cells through CXCR5
CXCR5 - Answers receptor for CXCL13 in immature B cells, causing their attraction to DCs
DSBR - Answers V(D)J recombinase responsible for ds break repair
RAG - Answers V(D)J recombinase responsible for gene activation
TdT - Answers V(D)J recombinase responsible for terminal deoxynucleotidyl transfer
B7 - Answers co-stimulatory molecule in DCs that bind naive T cells (signal 2)
CD28 - Answers naive T cell receptor for signal 2
ITAM - Answers phosphorylated during TCR/MHC binding
ZAP-70 - Answers binds phosphorylated ITAM, activating Lck
L-selectin - Answers interrupted upon T-cell activation
LFA-1 and CD44 - Answers over-expressed upon T-cell activation
