MICB 4131 - EXAM 2 QUIESTIONS WITH VERIFIED SOLUTIONS LATEST UPDATE 2026
there is only 1 type of effector CD4 T cell - Answers false
negative selection occurs in lymph nodes where most self antigen is found - Answers false
positive selection is necessary to ensure your T cells can recognize foreign MHC - Answers false
clonal expansion refers to - Answers (none of the above)
effector T cells are - Answers antigen-experienced
memory T cells are - Answers antigen-experienced
B and T cell development occur in the bone marrow - Answers false
IL-2 is made by naive T cells - Answers false
B cell development is dependent on somatic hypermutation - Answers false
Naïve T cells are enriched in these locations - Answers Lymph nodes
Compared to naïve T cells, memory T cells express more - Answers CD44
Tdt enzyme is important for - Answers Junctional diversity within the antigen-binding groove of
lymphocyte receptors, Adding P or palindromic nucleotides, Adding N or non-template encoded
nucleotides
VDJ recombination occurs during B cell development and T cell development - Answers True
RSS (recombination signal sequences) are important during T cell priming - Answers False
CD3 performs a function similar to Iga/Igb - Answers True
The transcription factor AIRE is important during - Answers Negative selection
Mutations resulting in loss of function in RAG enzymes will result in - Answers no B cells and no T cells
CD4 interacts with MHC II on CD8 T cells - Answers False
Reasons effector T cells go through a contraction phase may include - Answers Low bcl-2 expression,
Low CD127 (a component of the IL-7 receptor) expression, Decreased amount of IL-2
There are 2 different classes of T cell receptor (TCR): either ad or bg - Answers False
Transcription factors that can be induced after TCR stimulation are - Answers AP-1
CD4 T cells have the potential to recognize antigen on all cells in your body - Answers False
Anergy results from lack of - Answers signal 2
IL-2 is required for naïve T cell survival - Answers False
Signal 3 are cytokines, which direct the differentiation pathway of T cells during
activation - Answers True
During T cell development, the earliest progenitor cells in the thymus are CD3+ and
CD4+, known as double positive (DP) cells - Answers False
The function of the pre-Ta chain during T cell activation is analogous to the function of the
VpreB/lambda5 chain during B cell development - Answers False
Immunoglobulin heavy and light genes have V, D and J segments - Answers False
The ligand for CD28 is ______. This ligand is found on _____ cells - Answers B7; APC
This region of an antibody is how immune cells and immune components recognize
antibodies - Answers Fc
This antibody isotype helps protect the developing fetus - Answers IgG
This antibody isotype generally has a lower affinity. This can be overcome by formation of a
pentamer - Answers IgM
Passive immunity (transfer of antibodies in the serum) provides long lasting (lifelong)
protection - Answers False
Isotype switching can move in both directions. For example, after a cell switches from IgM
to IgG it can switch back to IgM - Answers False
Thymus independent antigens can induce antibodies when - Answers The antigens are highly dense
and repetitive, The antigens bind in the presence of a PAMP
Somatic hypermutation happens in the - Answers LN germinal center
Hyper IgM syndrome can happen when there are mutations in - Answers AID, CD40, CD40L
This cytokine receptor is needed early in B cell development in the bone marrow - Answers IL-7R
IL-7R uses the common gamma chain - Answers true
This protein checks for successful rearrangement of the heavy chain. - Answers VpreB
FDC recruit immature B cells to the primary follicle in the LN for the final maturation step through this
chemokine - Answers CXCL13
_______ creates antibody diversity while_______ increases antibody affinity - Answers VDJ
recombination; Somatic hypermutation
there is only 1 type of effector CD4 T cell - Answers false
negative selection occurs in lymph nodes where most self antigen is found - Answers false
positive selection is necessary to ensure your T cells can recognize foreign MHC - Answers false
clonal expansion refers to - Answers (none of the above)
effector T cells are - Answers antigen-experienced
memory T cells are - Answers antigen-experienced
B and T cell development occur in the bone marrow - Answers false
IL-2 is made by naive T cells - Answers false
B cell development is dependent on somatic hypermutation - Answers false
Naïve T cells are enriched in these locations - Answers Lymph nodes
Compared to naïve T cells, memory T cells express more - Answers CD44
Tdt enzyme is important for - Answers Junctional diversity within the antigen-binding groove of
lymphocyte receptors, Adding P or palindromic nucleotides, Adding N or non-template encoded
nucleotides
VDJ recombination occurs during B cell development and T cell development - Answers True
RSS (recombination signal sequences) are important during T cell priming - Answers False
CD3 performs a function similar to Iga/Igb - Answers True
The transcription factor AIRE is important during - Answers Negative selection
Mutations resulting in loss of function in RAG enzymes will result in - Answers no B cells and no T cells
CD4 interacts with MHC II on CD8 T cells - Answers False
Reasons effector T cells go through a contraction phase may include - Answers Low bcl-2 expression,
Low CD127 (a component of the IL-7 receptor) expression, Decreased amount of IL-2
There are 2 different classes of T cell receptor (TCR): either ad or bg - Answers False
Transcription factors that can be induced after TCR stimulation are - Answers AP-1
CD4 T cells have the potential to recognize antigen on all cells in your body - Answers False
Anergy results from lack of - Answers signal 2
IL-2 is required for naïve T cell survival - Answers False
Signal 3 are cytokines, which direct the differentiation pathway of T cells during
activation - Answers True
During T cell development, the earliest progenitor cells in the thymus are CD3+ and
CD4+, known as double positive (DP) cells - Answers False
The function of the pre-Ta chain during T cell activation is analogous to the function of the
VpreB/lambda5 chain during B cell development - Answers False
Immunoglobulin heavy and light genes have V, D and J segments - Answers False
The ligand for CD28 is ______. This ligand is found on _____ cells - Answers B7; APC
This region of an antibody is how immune cells and immune components recognize
antibodies - Answers Fc
This antibody isotype helps protect the developing fetus - Answers IgG
This antibody isotype generally has a lower affinity. This can be overcome by formation of a
pentamer - Answers IgM
Passive immunity (transfer of antibodies in the serum) provides long lasting (lifelong)
protection - Answers False
Isotype switching can move in both directions. For example, after a cell switches from IgM
to IgG it can switch back to IgM - Answers False
Thymus independent antigens can induce antibodies when - Answers The antigens are highly dense
and repetitive, The antigens bind in the presence of a PAMP
Somatic hypermutation happens in the - Answers LN germinal center
Hyper IgM syndrome can happen when there are mutations in - Answers AID, CD40, CD40L
This cytokine receptor is needed early in B cell development in the bone marrow - Answers IL-7R
IL-7R uses the common gamma chain - Answers true
This protein checks for successful rearrangement of the heavy chain. - Answers VpreB
FDC recruit immature B cells to the primary follicle in the LN for the final maturation step through this
chemokine - Answers CXCL13
_______ creates antibody diversity while_______ increases antibody affinity - Answers VDJ
recombination; Somatic hypermutation
