MODULE 1-6 Review
Cellular/Fluid Regulation
Fluid Movement
1. Passive Transport
No Energy Required
Movement ↓ Concentration Gradient
Osmosis
Water moves from low solute high solute
Driven mainly by sodium concentration
Diffusion Facilitated Diffusion
Solutes move from high low Uses carrier protein
concentration Still no ATP
Example: O2 and CO2 exchange Example: Glucose Transport
2. Active Transport
Energy Required
Primary Active Transport Secondary Active Transport
Uses ATP directly Uses energy indirectly
Example: Na+/K- Pump Example: Sodium-glucose cotransport
, 3. Tonicity
Isotonic Hypotonic Hypertonic
No net water movement Water moves into cell Water moves out of cell
Cells stay the same size Cells swell Cells shrink
Electrolytes
Sodium Imbalances
Hyponatremia: ↓ Sodium Hypernatremia: ↑ Sodium
Water moves into cells cellular swelling Water moves out of cells cellular
dehydration
Etiology:
Deficient sodium Etiology:
Diuretic use Dehydration
Excessive sweating Excess sweating
Adrenal insufficiency Diarrhea
Excessive water Diabetes Insipidus
Hyperglycemia
Renal failure Clinical Manifestations:
SIADH Dry mucous membranes
Heart Failure Irritability
Muscle twitching
Clinical Manifestations: Confusion
Pulse changes Seizures
Edema
Headache, Lethargy, Confusion
Muscle Weakness, Cramping, Seizures
Nausea
Anorexia
Poor skin turgor
Cellular/Fluid Regulation
Fluid Movement
1. Passive Transport
No Energy Required
Movement ↓ Concentration Gradient
Osmosis
Water moves from low solute high solute
Driven mainly by sodium concentration
Diffusion Facilitated Diffusion
Solutes move from high low Uses carrier protein
concentration Still no ATP
Example: O2 and CO2 exchange Example: Glucose Transport
2. Active Transport
Energy Required
Primary Active Transport Secondary Active Transport
Uses ATP directly Uses energy indirectly
Example: Na+/K- Pump Example: Sodium-glucose cotransport
, 3. Tonicity
Isotonic Hypotonic Hypertonic
No net water movement Water moves into cell Water moves out of cell
Cells stay the same size Cells swell Cells shrink
Electrolytes
Sodium Imbalances
Hyponatremia: ↓ Sodium Hypernatremia: ↑ Sodium
Water moves into cells cellular swelling Water moves out of cells cellular
dehydration
Etiology:
Deficient sodium Etiology:
Diuretic use Dehydration
Excessive sweating Excess sweating
Adrenal insufficiency Diarrhea
Excessive water Diabetes Insipidus
Hyperglycemia
Renal failure Clinical Manifestations:
SIADH Dry mucous membranes
Heart Failure Irritability
Muscle twitching
Clinical Manifestations: Confusion
Pulse changes Seizures
Edema
Headache, Lethargy, Confusion
Muscle Weakness, Cramping, Seizures
Nausea
Anorexia
Poor skin turgor