1. A 24-year-old woman with recurrent genital herpes asks why her symptoms keep returning.
Which of the following best explains the reason for recurrent episodes?
A. Antiviral resistance causes continuous infection
B. HSV mutates each time it infects cells
C. HSV establishes lifelong latency and can reactivate under certain triggers
D. The immune system fails to recognize HSV completely
2. An infant boy is brought in for a routine postnatal examination. On examination, the urethral
meatus is noted to be on the dorsal aspect of the penis. Which of the following congenital
anomalies is most consistent with this finding?
A. Epispadia
B. Hydrocele
C. Hypospadia
D. Hernia
3. In the development of testicular germ cell tumors, which of the following factors is most
closely linked to the pathophysiology of these cancers?
A. Chronic testicular torsion
B. Cryptorchidism
C. Exposure to estrogen
D. Low testosterone levels
4. A 45-year-old woman with secondary amenorrhea is found to have elevated prolactin levels.
Which of the following is the best explanation for the role of prolactin in causing amenorrhea?
A. Prolactin decreases the production of progesterone
B. Prolactin inhibits the release of gonadotropin-releasing hormone (GnRH)
C. Prolactin increases the release of FSH, leading to anovulation
D. Prolactin stimulates excessive estrogen production
5. A 42-year-old woman presents with irregular menstrual bleeding. Endometrial biopsy shows
proliferative endometrium without secretory changes. Which of the following is the most likely
pathophysiological cause of her abnormal uterine bleeding?
A. Anovulation causing prolonged estrogen exposure without progesterone
B. Excessive progesterone secretion by the corpus luteum
C. Ovulatory cycles causing normal endometrial shedding
D. Reduced estrogen sensitivity of the endometrium
6. Which of the following best describes the microbiologic characteristics of human
immunodeficiency virus?
A. A single-stranded DNA virus that replicates in the cytoplasm of host cells
B. A double-stranded RNA virus that requires an RNA-dependent RNA polymerase for replication
C. A single-stranded RNA retrovirus that uses reverse transcriptase to produce DNA
D. A double-stranded DNA virus that integrates into the host cell's nucleus