NSG 533 ADVANCED PHARMACOLOGY k k k
TEST 1 WEEK 4 QUESTIONS WITH
k k k k k k
LATEST SOLUTIONS k
Which of the following SSRIs requires up to a 5-week washout period because
k k k k k k k k k k k k
of the long half-life of its potent active metabolite?
k k k k k k k k k
A. Escitalopram
B. Fluvoxamine
C. Fluoxetine
D. Sertraline - ans--C k k
Which of the following symptoms is most likely to improve within
k k k k k k k k k k
approximately 1 week of starting treatment?
k k k k k k
A. Depressed mood k
B. Suicidal thoughts k
C. Anhedonia
D. Sleep - ans--D k k
Of the following combinations of medications, which one would you want to avoid?
k k k k k k k k k k k k
A. Fluoxetine-lithium
B. Fluoxetine-phenelzine
C. Citalopram-valproic acid k
D. Citalopram-aripiprazole - ans--B k k
A 26-year-old man with a history of depression has been taking sertraline 200
k k k k k k k k k k k k
mg/day for 12 weeks with no response. The patient has no other
k k k k k k k k k k k k
complications. The physician asks for your recommendation. The most
k k k k k k k k k
reasonable recommendation would be to:
k k k k k
A. Increase sertraline k
B. Add fluoxetine
k
C. Switch to amitriptyline k k
D. Change to venlafaxine k k
E. Decrease sertraline - ans--D k k k
Which of the following is a dangerous combination?
k k k k k k k
A. MAOI-lorazepam
B. MAOI-acetaminophen
C. MAOI-meperidine
D. MAOI-ziprasidone - ans--C k k
A 23-year-old married white woman comes to the outpatient psychiatric clinic
k k k k k k k k k k
complaining of decreased sleep, decreased appetite, decreased
k k k k k k k
concentration, depressed
k k
, mood, thoughts of death, and lack of interest in activities for 6 weeks' duration.
k k k k k k k k k k k k k
She has no history of psychiatric illness and takes no medications except for
k k k k k k k k k k k k k
Ortho-Tri Cyclen Lo daily. Based upon the patients symptoms, choose the best
k k k k k k k k k k k k
medication to treat this patient.
k k k k k
A. Nefazodone 100 mg po twice daily k k k k k
B. Paroxetine 20 mg po daily k k k k
C. St. John's wort 300 mg po three times daily
k k k k k k k k
D. Amitriptyline 25 mg at bedtime - ans--B k k k k k k
A 36-year-old man is admitted to the hospital for a severe methicillin-resistant
k k k k k k k k k k k
Staphylococcus aureus diabetic foot infection and is started on linezolid 600
k k k k k k k k k k k
mg IV every 12 hours. His medication profile includes paroxetine 40 mg every
k k k k k k k k k k k k k
morning, trazodone 100 mg at bedtime as needed for sleep, and metformin
k k k k k k k k k k k k
1000 mg po twice daily. After 3
k k k k k k k
days on these medications, the patient becomes agitated, confused, and
k k k k k k k k k
diaphoretic and develops myoclonic jerks. Which of the following is the most
k k k k k k k k k k k k
likely diagnosis?
k k
A. Overdose of metformin k k
B. Bacterial meningitis k
C. Neuroleptic malignant syndrome k k
D. Serotonin syndrome - ans--D k k k
A 46-year-old woman presents to the psychiatric outpatient clinic for follow-up
k k k k k k k k k k
treatment of major depression. She is currently on paroxetine 10 mg at
k k k k k k k k k k k k
bedtime, which she started taking 2 months ago when admitted to the
k k k k k k k k k k k k
psychiatric hospital for suicidal ideation.
k k k k k
During the interview, she says that she does not think the medication is
k k k k k k k k k k k k
working because she is just as depressed as she was before taking the
k k k k k k k k k k k k k
medication and has recently started drinking eight to 10 beers daily to
k k k k k k k k k k k k
alleviate the depression. Before this episode, she was
k k k k k k k k
sober for 4 years. Which of the following treatment strategies would be the
k k k k k k k k k k k k
appropriate choice for this patient?
k k k k k
A. Stop the paroxetine and start nefazodone 100 mg po twice daily
k k k k k k k k k k
B. Increase the dose of paroxetine to 20 mg po at bedtime k k k k k k k k k k
C. Stop the paroxetine and start duloxetine 20 mg/day
k k k k k k k
D. Continue the paroxetine at them same dose for a longer period of time to k k k k k k k k k k k k k
evaluate whether she will res - ans--B
k k k k k k k
Which of the following is a flaw in the monoamine hypothesis of depression?
k k k k k k k k k k k k
A. Concentrations of neurotransmitters are reduced in the synaptic cleft k k k k k k k k
B. A switch to a different class of antidepressants does not improve response
k k k k k k k k k k k
C. Antidepressant response is associated with a therapeutic level of the k k k k k k k k k
medication
k
D. Antidepressant effects on neurotransmitters do not temporally k k k k k k
correspond to response. - ans--D
k k k k k
TEST 1 WEEK 4 QUESTIONS WITH
k k k k k k
LATEST SOLUTIONS k
Which of the following SSRIs requires up to a 5-week washout period because
k k k k k k k k k k k k
of the long half-life of its potent active metabolite?
k k k k k k k k k
A. Escitalopram
B. Fluvoxamine
C. Fluoxetine
D. Sertraline - ans--C k k
Which of the following symptoms is most likely to improve within
k k k k k k k k k k
approximately 1 week of starting treatment?
k k k k k k
A. Depressed mood k
B. Suicidal thoughts k
C. Anhedonia
D. Sleep - ans--D k k
Of the following combinations of medications, which one would you want to avoid?
k k k k k k k k k k k k
A. Fluoxetine-lithium
B. Fluoxetine-phenelzine
C. Citalopram-valproic acid k
D. Citalopram-aripiprazole - ans--B k k
A 26-year-old man with a history of depression has been taking sertraline 200
k k k k k k k k k k k k
mg/day for 12 weeks with no response. The patient has no other
k k k k k k k k k k k k
complications. The physician asks for your recommendation. The most
k k k k k k k k k
reasonable recommendation would be to:
k k k k k
A. Increase sertraline k
B. Add fluoxetine
k
C. Switch to amitriptyline k k
D. Change to venlafaxine k k
E. Decrease sertraline - ans--D k k k
Which of the following is a dangerous combination?
k k k k k k k
A. MAOI-lorazepam
B. MAOI-acetaminophen
C. MAOI-meperidine
D. MAOI-ziprasidone - ans--C k k
A 23-year-old married white woman comes to the outpatient psychiatric clinic
k k k k k k k k k k
complaining of decreased sleep, decreased appetite, decreased
k k k k k k k
concentration, depressed
k k
, mood, thoughts of death, and lack of interest in activities for 6 weeks' duration.
k k k k k k k k k k k k k
She has no history of psychiatric illness and takes no medications except for
k k k k k k k k k k k k k
Ortho-Tri Cyclen Lo daily. Based upon the patients symptoms, choose the best
k k k k k k k k k k k k
medication to treat this patient.
k k k k k
A. Nefazodone 100 mg po twice daily k k k k k
B. Paroxetine 20 mg po daily k k k k
C. St. John's wort 300 mg po three times daily
k k k k k k k k
D. Amitriptyline 25 mg at bedtime - ans--B k k k k k k
A 36-year-old man is admitted to the hospital for a severe methicillin-resistant
k k k k k k k k k k k
Staphylococcus aureus diabetic foot infection and is started on linezolid 600
k k k k k k k k k k k
mg IV every 12 hours. His medication profile includes paroxetine 40 mg every
k k k k k k k k k k k k k
morning, trazodone 100 mg at bedtime as needed for sleep, and metformin
k k k k k k k k k k k k
1000 mg po twice daily. After 3
k k k k k k k
days on these medications, the patient becomes agitated, confused, and
k k k k k k k k k
diaphoretic and develops myoclonic jerks. Which of the following is the most
k k k k k k k k k k k k
likely diagnosis?
k k
A. Overdose of metformin k k
B. Bacterial meningitis k
C. Neuroleptic malignant syndrome k k
D. Serotonin syndrome - ans--D k k k
A 46-year-old woman presents to the psychiatric outpatient clinic for follow-up
k k k k k k k k k k
treatment of major depression. She is currently on paroxetine 10 mg at
k k k k k k k k k k k k
bedtime, which she started taking 2 months ago when admitted to the
k k k k k k k k k k k k
psychiatric hospital for suicidal ideation.
k k k k k
During the interview, she says that she does not think the medication is
k k k k k k k k k k k k
working because she is just as depressed as she was before taking the
k k k k k k k k k k k k k
medication and has recently started drinking eight to 10 beers daily to
k k k k k k k k k k k k
alleviate the depression. Before this episode, she was
k k k k k k k k
sober for 4 years. Which of the following treatment strategies would be the
k k k k k k k k k k k k
appropriate choice for this patient?
k k k k k
A. Stop the paroxetine and start nefazodone 100 mg po twice daily
k k k k k k k k k k
B. Increase the dose of paroxetine to 20 mg po at bedtime k k k k k k k k k k
C. Stop the paroxetine and start duloxetine 20 mg/day
k k k k k k k
D. Continue the paroxetine at them same dose for a longer period of time to k k k k k k k k k k k k k
evaluate whether she will res - ans--B
k k k k k k k
Which of the following is a flaw in the monoamine hypothesis of depression?
k k k k k k k k k k k k
A. Concentrations of neurotransmitters are reduced in the synaptic cleft k k k k k k k k
B. A switch to a different class of antidepressants does not improve response
k k k k k k k k k k k
C. Antidepressant response is associated with a therapeutic level of the k k k k k k k k k
medication
k
D. Antidepressant effects on neurotransmitters do not temporally k k k k k k
correspond to response. - ans--D
k k k k k
