10/31/2024
Microcytic anaemias
October 31, 2024 Prepared by: Mire 1
Microcytic anemias
An important mechanism of anemia is
defective hemoglobin synthesis, which
results in small, poorly hemoglobinized
erythrocytes.
October 31, 2024 Prepared by: Mire 2
Prepared by : Mire 1
, 10/31/2024
CONT,,,
Since hemoglobin is made up of two components,
either of two pathophysiologic mechanisms can
lead to decrease hemoglobin synthesis:
a) Defective heme or
b) Decreased globin production.
October 31, 2024 Prepared by: Mire 3
CONT,,,
Heme is made up of iron and porphyrins; deficiencies in
either affect heme production.
Deficiency of iron store, failure to utilize iron properly, are
characteristic of :
I. Iron deficiency anemia, and
II. Anemia of chronic disease,
Defective heme or porphyrin synthesis are characteristic of :
I. Sideroblastic anemias.
October 31, 2024 Prepared by: Mire 4
Prepared by : Mire 2
, 10/31/2024
CONT,,,
In thalassemia syndromes, globin production
is decreased, thereby hindering hemoglobin
synthesis and producing a microcytic anemia.
October 31, 2024 Prepared by: Mire 5
Iron deficiency anaemia
( IDA )
October 31, 2024 Prepared by: Mire 6
Prepared by : Mire 3
, 10/31/2024
Iron deficiency anemia( IDA )
Iron deficiency is the commonest cause of
anemia in every country of the world.
It is the most important, but not sole, cause of a
microcytic, hypochromic anemia.
October 31, 2024 Prepared by: Mire 7
CONT,,,
Iron deficiency anaemia ( IDA ) is characterized
by microcytic hypochromic red cell with MCV <
80 fl and MCH < 25pg.
Morphologic changes of red cells appear as the iron
stores get depleted and iron is not available in
adequate amounts for haem synthesis.
October 31, 2024 Prepared by: Mire 8
Prepared by : Mire
4
Microcytic anaemias
October 31, 2024 Prepared by: Mire 1
Microcytic anemias
An important mechanism of anemia is
defective hemoglobin synthesis, which
results in small, poorly hemoglobinized
erythrocytes.
October 31, 2024 Prepared by: Mire 2
Prepared by : Mire 1
, 10/31/2024
CONT,,,
Since hemoglobin is made up of two components,
either of two pathophysiologic mechanisms can
lead to decrease hemoglobin synthesis:
a) Defective heme or
b) Decreased globin production.
October 31, 2024 Prepared by: Mire 3
CONT,,,
Heme is made up of iron and porphyrins; deficiencies in
either affect heme production.
Deficiency of iron store, failure to utilize iron properly, are
characteristic of :
I. Iron deficiency anemia, and
II. Anemia of chronic disease,
Defective heme or porphyrin synthesis are characteristic of :
I. Sideroblastic anemias.
October 31, 2024 Prepared by: Mire 4
Prepared by : Mire 2
, 10/31/2024
CONT,,,
In thalassemia syndromes, globin production
is decreased, thereby hindering hemoglobin
synthesis and producing a microcytic anemia.
October 31, 2024 Prepared by: Mire 5
Iron deficiency anaemia
( IDA )
October 31, 2024 Prepared by: Mire 6
Prepared by : Mire 3
, 10/31/2024
Iron deficiency anemia( IDA )
Iron deficiency is the commonest cause of
anemia in every country of the world.
It is the most important, but not sole, cause of a
microcytic, hypochromic anemia.
October 31, 2024 Prepared by: Mire 7
CONT,,,
Iron deficiency anaemia ( IDA ) is characterized
by microcytic hypochromic red cell with MCV <
80 fl and MCH < 25pg.
Morphologic changes of red cells appear as the iron
stores get depleted and iron is not available in
adequate amounts for haem synthesis.
October 31, 2024 Prepared by: Mire 8
Prepared by : Mire
4
