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Exam 3- Anticoag Pharmacology: Antihypertensive Dr... PHARM FINAL Enodcr
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Therapeutic outcome raloxifene (Evista) decreases bone reabsorption; slows down bone loss and preserves mineral
density in postmenopausal osteoporosis
Also used to protect again breast cancer
Penicillin adverse effects: Allergies/anaphylaxis , renal impairment
Macrolide Prototype Drug erythromycin (e-mycin)
Airflow Disorders: Teaching About Theophylline If dysrhythmias or seizure occur, stop medication.
Periodic blood levels are needed.
Report nausea, diarrhea, or restlessness.
Avoid consuming caffeinated beverages.
digoxin toxicity symptoms fatigue, weakness, vision changes, GI effects
digoxin level 0.5 to 2.0 ng/mL
How to give digoxin infuse over at least 5 min, and monitor client for dysrhythmias.
, Management of digoxin toxicity Digoxin and potassium-sparing medication should be stopped immediately.
Monitor K+ levels. For levels less than 3.5 mEq/L, administer potassium IV or by
mouth. Do not
give any further K+ if the level is greater than 5.0 mEq/L.
Treat dysrhythmias with phenytoin (Dilantin) or lidocaine.
Treat bradycardia with atropine.
For excessive overdose, activated charcoal, cholestyramine, or Digibind can be
used to bind digoxin and prevent absorption
How to Treat dysrhythmias for digoxin toxicity patients Phenytoin
Lidocaine
Cyclophosphamide Alkylating agent (nitrogen mustard) Bone marrow suppression
Adverse effects:
Gi discomfort (N/V)
Acute hemorrhagic cystitis > monitor for hematuria, mesna can be given
Alopecia
Cyclophosphamide interactions Succinylcholine > increased neuromuscular blockade
Tricyclic Antidepressants Adverse Reactions -Orthostatic hypotension
-Anticholinergic effects
-Sedation
-Toxicity
-Decrease seizure threshold
-Excessive sweating
controlled substances Each level has a decreasing risk of abuse & dependence. For example, morphine
(Duramorph) is a schedule II medication that has greater risk of abuse &
dependence than phenobarbital (Luminal), which is a Schedule IV medication
-Us Food & Drug Administration Pregnancy Risk Category (A, B, C, D, X) classifies
medication in terms of their potential harm during pregnancy, with Category A
being safest & Category X the most dangerous. Teratogenesis is most likely to
occur during 1st trimester. Before giving any medication to a woman who is
pregnant or could be pregnant, determine whether or not it is safe for
administration during pregnancy
Tricyclic Antidepressants (TCAs) Imipramine (Tofranil)
Doxepin (Sinequan)
Nortriptyline (Aventyl)
Amoxapine (Asendin)
Trimipramine (Surmontil)
Anticholinergic effects Sx Dry mouth, blurred vision, photophobia, urinary hesitancy or retention,
constipation, tachycardia