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ATI Adult Medical Surgical Nursing CMS Exam Questions & Answers with Expert Explanations 2026–2027 | Complete A+ Guide

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Master your ATI Adult Medical Surgical Nursing CMS Exam 2026–2027 and excel with confidence using this comprehensive study resource. Featuring actual exam-style questions with expert-verified answers and detailed explanations, this guide helps nursing students strengthen clinical judgment, medical-surgical nursing knowledge, and patient care decision-making, ensuring full readiness for ATI Content Mastery Series exams. The material covers cardiovascular, respiratory, endocrine, gastrointestinal, renal, neurological, musculoskeletal, and immune disorders, along with pharmacology, priority nursing interventions, patient safety, and evidence-based clinical management, providing a complete review to help students master essential med-surg concepts and achieve top scores.

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Page 1 of 44




ATI Adult Medical Surgical Nursing (CMS)

Exam Actual Questions and Answers With

Expert Explanation (2026/2027 Update) |

Complete A+ Guide




1. A nurse is assessing a client with left-sided heart failure.

Which finding is most expected?

A. Jugular vein distention

B. Peripheral edema

C. Crackles in lung bases

D. Hepatomegaly

Answer: C. Crackles in lung bases

,Page 2 of 44




Rationale: Left-sided heart failure causes fluid backup into the

lungs (pulmonary congestion), leading to crackles. JVD,

peripheral edema, and hepatomegaly are signs of right-sided


failure.

2. A client post-MI develops chest pain unrelieved by

nitroglycerin. The nurse should first:

A. Administer morphine sulfate

B. Repeat nitroglycerin

C. Obtain an ECG

D. Assess blood pressure

Answer: D. Assess blood pressure

Rationale: Before administering further nitroglycerin or

morphine, assess BP to prevent hypotension. After assessment,

notify provider and obtain ECG.

3. A nurse is teaching a client with hypertension about

dietary changes. Which statement indicates understanding?

,Page 3 of 44




A. “I can use salt substitutes freely.”

B. “I should limit potassium-rich foods.”

C. “I will read labels for sodium content.”

D. “I need to avoid all fats.”

Answer: C. “I will read labels for sodium content.” Rationale:

Sodium restriction is key. Salt substitutes contain potassium,

which may be harmful if on ACE inhibitors/ARBs (risk of

hyperkalemia). Healthy fats are allowed.

4. A client with atrial fibrillation is prescribed warfarin. The

nurse should monitor:

A. aPTT

B. INR

C. Platelet count

D. Bleeding time

Answer: B. INR

, Page 4 of 44




Rationale: Warfarin therapy is monitored with INR

(therapeutic range 2-3 for atrial fibrillation). aPTT monitors

heparin.


5. A client post-cardiac catheterization via femoral artery

reports numbness in the foot. The nurse’s priority action is:

A. Elevate the leg

B. Check pedal pulses

C. Apply warm compress

D. Administer pain medication

Answer: B. Check pedal pulses

Rationale: Numbness may indicate arterial occlusion. Assess

circulation (pulses, color, temperature, sensation) immediately.

Notify provider if diminished.

(Continue to 40 with similar depth)



Section 2: Respiratory Disorders (Questions 41–80)

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