CHEMOTHERAPY AND IMMUNOTHERAPY COMPREHENSIVE EXAM READY|
VERIFIED QUESTIONS AND ANSWERS - COMPREHENSIVE | LATEST VERSION
2026/2027 (PASS GUARANTEE)
CHEMO / IMMUNO COMPLETE EXAM
1. Which phase of the cell cycle is targeted by antimetabolite chemotherapy
agents?
A. G0 phase
B. G1 phase
C. S phase
D. M phase
2. Cyclophosphamide belongs to which class of chemotherapy agents?
A. Antimetabolites
B. Alkylating agents
C. Topoisomerase inhibitors
D. Vinca alkaloids
3. What is the primary mechanism of action of methotrexate?
A. DNA alkylation
B. Inhibition of dihydrofolate reductase
C. Microtubule stabilization
D. Topoisomerase II inhibition
4. Leucovorin rescue is used after high-dose methotrexate to:
A. Enhance tumor cell kill
B. Rescue normal cells from folate depletion
C. Increase renal clearance
, D. Prevent CNS toxicity
5. The dose-limiting toxicity of bleomycin is:
A. Nephrotoxicity
B. Pulmonary fibrosis
C. Cardiotoxicity
D. Peripheral neuropathy
6. Which platinum compound is considered least nephrotoxic?
A. Cisplatin
B. Carboplatin
C. Oxaliplatin
D. Satraplatin
7. Doxorubicin's cumulative cardiotoxicity is related to:
A. Total cumulative dose
B. Rate of infusion
C. Patient age
D. Concurrent radiation only
8. Vincristine causes which toxicity not typically seen with vinblastine?
A. Myelosuppression
B. Peripheral neuropathy
C. Mucositis
D. Alopecia
9. 5-Fluorouracil (5-FU) is used to treat all of the following EXCEPT:
A. Colorectal cancer
B. Breast cancer
C. Chronic myeloid leukemia
D. Head and neck cancer
10. The primary mechanism of 5-FU cytotoxicity is:
A. Inhibition of thymidylate synthase
B. DNA alkylation
C. Topoisomerase I inhibition
D. Microtubule disruption
,11. Irinotecan targets which enzyme?
A. Topoisomerase II
B. Topoisomerase I
C. DNA polymerase
D. RNA polymerase
12. Which agent requires hyperhydration and mannitol diuresis to prevent
toxicity?
A. Carboplatin
B. Oxaliplatin
C. Cisplatin
D. Paclitaxel
13. Docetaxel and paclitaxel belong to which drug class?
A. Vinca alkaloids
B. Anthracyclines
C. Taxanes
D. Epipodophyllotoxins
14. Gemcitabine is a nucleoside analog of:
A. Adenosine
B. Deoxycytidine
C. Thymidine
D. Guanosine
15. The antidote for anthracycline extravasation is:
A. Sodium thiosulfate
B. Dexrazoxane
C. Leucovorin
D. Mesna
16. Mesna is co-administered with which agents to prevent hemorrhagic
cystitis?
A. Platinum compounds
B. Anthracyclines
C. Oxazaphosphorines (cyclophosphamide, ifosfamide)
D. Taxanes
, 17. Etoposide (VP-16) inhibits:
A. Topoisomerase I
B. Topoisomerase II
C. Dihydrofolate reductase
D. Thymidylate synthase
18. Which chemotherapy agent is associated with hand-foot syndrome (palmar-
plantar erythrodysesthesia)?
A. Cisplatin
B. Capecitabine
C. Bleomycin
D. Vincristine
19. Tumor lysis syndrome is most commonly seen after chemotherapy for:
A. Colorectal cancer
B. High-grade lymphoma or acute leukemia
C. Breast cancer
D. Lung adenocarcinoma
20. Which electrolyte abnormality is NOT characteristic of tumor lysis
syndrome?
A. Hyperkalemia
B. Hyperphosphatemia
C. Hypercalcemia
D. Hyperuricemia
21. Rasburicase is used in tumor lysis syndrome to:
A. Bind phosphate
B. Convert uric acid to allantoin
C. Correct hyperkalemia
D. Alkalinize urine
22. The CHOP regimen consists of all of the following EXCEPT:
A. Cyclophosphamide
B. Hydroxydaunorubicin (doxorubicin)
C. Oxaliplatin
D. Prednisone
VERIFIED QUESTIONS AND ANSWERS - COMPREHENSIVE | LATEST VERSION
2026/2027 (PASS GUARANTEE)
CHEMO / IMMUNO COMPLETE EXAM
1. Which phase of the cell cycle is targeted by antimetabolite chemotherapy
agents?
A. G0 phase
B. G1 phase
C. S phase
D. M phase
2. Cyclophosphamide belongs to which class of chemotherapy agents?
A. Antimetabolites
B. Alkylating agents
C. Topoisomerase inhibitors
D. Vinca alkaloids
3. What is the primary mechanism of action of methotrexate?
A. DNA alkylation
B. Inhibition of dihydrofolate reductase
C. Microtubule stabilization
D. Topoisomerase II inhibition
4. Leucovorin rescue is used after high-dose methotrexate to:
A. Enhance tumor cell kill
B. Rescue normal cells from folate depletion
C. Increase renal clearance
, D. Prevent CNS toxicity
5. The dose-limiting toxicity of bleomycin is:
A. Nephrotoxicity
B. Pulmonary fibrosis
C. Cardiotoxicity
D. Peripheral neuropathy
6. Which platinum compound is considered least nephrotoxic?
A. Cisplatin
B. Carboplatin
C. Oxaliplatin
D. Satraplatin
7. Doxorubicin's cumulative cardiotoxicity is related to:
A. Total cumulative dose
B. Rate of infusion
C. Patient age
D. Concurrent radiation only
8. Vincristine causes which toxicity not typically seen with vinblastine?
A. Myelosuppression
B. Peripheral neuropathy
C. Mucositis
D. Alopecia
9. 5-Fluorouracil (5-FU) is used to treat all of the following EXCEPT:
A. Colorectal cancer
B. Breast cancer
C. Chronic myeloid leukemia
D. Head and neck cancer
10. The primary mechanism of 5-FU cytotoxicity is:
A. Inhibition of thymidylate synthase
B. DNA alkylation
C. Topoisomerase I inhibition
D. Microtubule disruption
,11. Irinotecan targets which enzyme?
A. Topoisomerase II
B. Topoisomerase I
C. DNA polymerase
D. RNA polymerase
12. Which agent requires hyperhydration and mannitol diuresis to prevent
toxicity?
A. Carboplatin
B. Oxaliplatin
C. Cisplatin
D. Paclitaxel
13. Docetaxel and paclitaxel belong to which drug class?
A. Vinca alkaloids
B. Anthracyclines
C. Taxanes
D. Epipodophyllotoxins
14. Gemcitabine is a nucleoside analog of:
A. Adenosine
B. Deoxycytidine
C. Thymidine
D. Guanosine
15. The antidote for anthracycline extravasation is:
A. Sodium thiosulfate
B. Dexrazoxane
C. Leucovorin
D. Mesna
16. Mesna is co-administered with which agents to prevent hemorrhagic
cystitis?
A. Platinum compounds
B. Anthracyclines
C. Oxazaphosphorines (cyclophosphamide, ifosfamide)
D. Taxanes
, 17. Etoposide (VP-16) inhibits:
A. Topoisomerase I
B. Topoisomerase II
C. Dihydrofolate reductase
D. Thymidylate synthase
18. Which chemotherapy agent is associated with hand-foot syndrome (palmar-
plantar erythrodysesthesia)?
A. Cisplatin
B. Capecitabine
C. Bleomycin
D. Vincristine
19. Tumor lysis syndrome is most commonly seen after chemotherapy for:
A. Colorectal cancer
B. High-grade lymphoma or acute leukemia
C. Breast cancer
D. Lung adenocarcinoma
20. Which electrolyte abnormality is NOT characteristic of tumor lysis
syndrome?
A. Hyperkalemia
B. Hyperphosphatemia
C. Hypercalcemia
D. Hyperuricemia
21. Rasburicase is used in tumor lysis syndrome to:
A. Bind phosphate
B. Convert uric acid to allantoin
C. Correct hyperkalemia
D. Alkalinize urine
22. The CHOP regimen consists of all of the following EXCEPT:
A. Cyclophosphamide
B. Hydroxydaunorubicin (doxorubicin)
C. Oxaliplatin
D. Prednisone
