HESI Pharmacology Mastery Pack 2026
| Practice Test Questions &
Medication Study Guide
THIS EXAM INCLUDES:
• Comprehensive HESI Pharmacology practice questions
• Detailed correct answers
• High-yield medication review notes
• NCLEX-style pharmacology exam preparation
• Drug classifications and mechanisms of action
• New 2026 Update
• All graded A+
,HESI Pharmacology Practice
1. The nurse reviews the new prescription, phenelzine (Nardil), a monoamine
oxidase inhibitor (MAOI), for a client with depression on the psychiatric unit.
Which information is most important for the nurse to assess?
A. Consumption of any alcohol or tyramine rich foods
B. Reports of nausea or vomiting
C. Therapeutic serum drug levels
D. Blood pressure and pulse prior to taking each dose
Answer: A
2. The nurse is administering haloperidol 0.5 mg IM PRN to a client for the first
time. What side effects should the nurse assess the client during the initial dose?
A. Bradykinesia
B. Dystonia
C. Somatization
D. Akathisia
Answer: B
3. While reviewing the client's electronic medical record (EMR), the nurse
assesses a client who is at risk for a possible interaction with an over-the-counter
(OTC) decongestant. Which client health history should the nurse report to the
health care provider concerning the OTC medication? (Select all that apply)
A. Type 1 diabetes mellitus (DM)
B. Closed angle glaucoma
C. Chronic hypertension
D. Rheumatoid arthritis
E. Crohn's disease
Answer: B, C
,4. A client prescribed ipratropium reports nausea, blurred vision, headaches, and
insomnia after using the inhaler. Which action should the nurse implement first?
A. Withhold the medication and report symptoms and vital signs to the healthcare
provider
(No other options listed in original — truncated)
Answer: A (based on standard testing principles)
5. A client diagnosed with multiple sclerosis is experiencing profound weakness,
blurry vision, and shooting pains in both legs. Which medication is considered the
best course of treatment for the nurse to administer?
A. High dose methylprednisolone intravenously
B. Baclofen three times a day
C. Broad spectrum antibiotic coverage orally
D. Immunomodulatory drug therapy periodically
Answer: A
6. The nurse administers 30 mL of lactulose for a client with stage 2 hepatic
encephalopathy. Which assessment finding would indicate the medication is
being therapeutic?
A. A decrease in blood ammonia levels
B. A softening in the stools
C. An increase in glucose absorption
D. A suppression of gut acidification
Answer: A
7. The nurse is teaching a client who is newly diagnosed with type 1 diabetes
about neutral protamine Hagedorn (NPH) insulin. Which statement by the client
indicates an understanding of how the medication works?
A. It facilitates the transport of glucose into the cells
, B. It stimulates the function of beta cells in the pancreas
C. It increases the intracellular receptor site sensitivity
D. It delays the carbohydrate digestion and absorption
Answer: A
8. The nurse should withhold which medication if a client reports nausea,
vomiting, and diarrhea?
(Options missing in original — question incomplete)
Answer: Not able to determine from text.
9. A client newly prescribed esomeprazole for gastroesophageal reflux disease
(GERD) asks the nurse how the medication will help. Which is the best explanation
to provide the client?
A. It will promote rapid tissue healing.
B. It will increase gastric emptying.
C. It will improve esophageal peristalsis.
D. It will neutralize gastric secretions.
Answer: A
10. A nurse is providing medication education for a client prescribed a beta-
blocking agent for treatment of glaucoma. Which statement by the client
demonstrates an understanding of the mechanism of the medication?
A. It inhibits the aqueous humor production.
B. It enhances the aqueous humor outflow.
C. It increases the intraocular pressure.
D. It prevents extraocular infection.
Answer: A
| Practice Test Questions &
Medication Study Guide
THIS EXAM INCLUDES:
• Comprehensive HESI Pharmacology practice questions
• Detailed correct answers
• High-yield medication review notes
• NCLEX-style pharmacology exam preparation
• Drug classifications and mechanisms of action
• New 2026 Update
• All graded A+
,HESI Pharmacology Practice
1. The nurse reviews the new prescription, phenelzine (Nardil), a monoamine
oxidase inhibitor (MAOI), for a client with depression on the psychiatric unit.
Which information is most important for the nurse to assess?
A. Consumption of any alcohol or tyramine rich foods
B. Reports of nausea or vomiting
C. Therapeutic serum drug levels
D. Blood pressure and pulse prior to taking each dose
Answer: A
2. The nurse is administering haloperidol 0.5 mg IM PRN to a client for the first
time. What side effects should the nurse assess the client during the initial dose?
A. Bradykinesia
B. Dystonia
C. Somatization
D. Akathisia
Answer: B
3. While reviewing the client's electronic medical record (EMR), the nurse
assesses a client who is at risk for a possible interaction with an over-the-counter
(OTC) decongestant. Which client health history should the nurse report to the
health care provider concerning the OTC medication? (Select all that apply)
A. Type 1 diabetes mellitus (DM)
B. Closed angle glaucoma
C. Chronic hypertension
D. Rheumatoid arthritis
E. Crohn's disease
Answer: B, C
,4. A client prescribed ipratropium reports nausea, blurred vision, headaches, and
insomnia after using the inhaler. Which action should the nurse implement first?
A. Withhold the medication and report symptoms and vital signs to the healthcare
provider
(No other options listed in original — truncated)
Answer: A (based on standard testing principles)
5. A client diagnosed with multiple sclerosis is experiencing profound weakness,
blurry vision, and shooting pains in both legs. Which medication is considered the
best course of treatment for the nurse to administer?
A. High dose methylprednisolone intravenously
B. Baclofen three times a day
C. Broad spectrum antibiotic coverage orally
D. Immunomodulatory drug therapy periodically
Answer: A
6. The nurse administers 30 mL of lactulose for a client with stage 2 hepatic
encephalopathy. Which assessment finding would indicate the medication is
being therapeutic?
A. A decrease in blood ammonia levels
B. A softening in the stools
C. An increase in glucose absorption
D. A suppression of gut acidification
Answer: A
7. The nurse is teaching a client who is newly diagnosed with type 1 diabetes
about neutral protamine Hagedorn (NPH) insulin. Which statement by the client
indicates an understanding of how the medication works?
A. It facilitates the transport of glucose into the cells
, B. It stimulates the function of beta cells in the pancreas
C. It increases the intracellular receptor site sensitivity
D. It delays the carbohydrate digestion and absorption
Answer: A
8. The nurse should withhold which medication if a client reports nausea,
vomiting, and diarrhea?
(Options missing in original — question incomplete)
Answer: Not able to determine from text.
9. A client newly prescribed esomeprazole for gastroesophageal reflux disease
(GERD) asks the nurse how the medication will help. Which is the best explanation
to provide the client?
A. It will promote rapid tissue healing.
B. It will increase gastric emptying.
C. It will improve esophageal peristalsis.
D. It will neutralize gastric secretions.
Answer: A
10. A nurse is providing medication education for a client prescribed a beta-
blocking agent for treatment of glaucoma. Which statement by the client
demonstrates an understanding of the mechanism of the medication?
A. It inhibits the aqueous humor production.
B. It enhances the aqueous humor outflow.
C. It increases the intraocular pressure.
D. It prevents extraocular infection.
Answer: A
