Aminoglycosides
Protein synthesis inhibitors classification according to mode of action
1. Drugs acting on 30S ribosomal subunit
a. Aminoglycosides (gentamicin, amikacin)
b. Tetracyclines (Doxycycline, tetracycline)
2. Drugs acting on 50S subunit:
a. Macrolides (erythromycin, clarithromycin)
b. Lincosamides (Clindamycin)
c. Chloramphenicol
d. Oxazolidinones (linezolid)
Aminoglycoside is a medicinal bacteriologic category of traditional gm -ve
antibiotic.
Inhibits protein synthesis and contains portion of amino-modified glycoside.
2 or more amino sugars are joined by glycosidic linkage to a central hexose
nucleus
Nomenclature:
Those derived from streptomyces and have mycin suffix
Those derived from micromonospora have micin suffix
e.g. Streptomycin, neomycin, tobramycin, paromomycin
Classification according to systemic or topical:
1. Systemic
a. Streptomycin
b. Tobramycin
c. Paromomycin
d. Gentamicin
e. Amikacin
2. Topical
a. Neomycin
b. Framycetin
Antibacterial spectrum:
Mainly against Gram -ve aerobic bacilli
Protein synthesis inhibitors classification according to mode of action
1. Drugs acting on 30S ribosomal subunit
a. Aminoglycosides (gentamicin, amikacin)
b. Tetracyclines (Doxycycline, tetracycline)
2. Drugs acting on 50S subunit:
a. Macrolides (erythromycin, clarithromycin)
b. Lincosamides (Clindamycin)
c. Chloramphenicol
d. Oxazolidinones (linezolid)
Aminoglycoside is a medicinal bacteriologic category of traditional gm -ve
antibiotic.
Inhibits protein synthesis and contains portion of amino-modified glycoside.
2 or more amino sugars are joined by glycosidic linkage to a central hexose
nucleus
Nomenclature:
Those derived from streptomyces and have mycin suffix
Those derived from micromonospora have micin suffix
e.g. Streptomycin, neomycin, tobramycin, paromomycin
Classification according to systemic or topical:
1. Systemic
a. Streptomycin
b. Tobramycin
c. Paromomycin
d. Gentamicin
e. Amikacin
2. Topical
a. Neomycin
b. Framycetin
Antibacterial spectrum:
Mainly against Gram -ve aerobic bacilli
