Penicillin mechanism:
Inhibit peptidoglycan synthesis
Beta-lactam antibiotics
Related structurally and functionally to penicillin
Produced semisynthetically
Derived from cephalosporin-C
Obtained from fungus – Cephalosporium
Bacteriocidal
MOA: Bacterial cell wall synthesis inhibition
Nucleus consists of β – lactam ring fused with dihydrothiazine
Classification
First gen:
1. Oral
a. Cephalexin
b. Cefadroxil
2. Parenteral
a. Cefazolin
Second gen::
1. Oral
a. Cefaclor
b. Cefprozil
2. Parenteral
a. Cefuroxime
Third gen:
1. Oral
a. Cefixime
b. Ceftibuten
2. Parenteral
a. Cefotaxime
b. Ceftriaxone
c. Ceftazidime
Fourth gen: