Protein synthesis inhibitors
They are antimicrobial agents that:
Inhibit bacterial protein synthesis
Act by targeting ribosomes; 30S or 50S
Slow/stop growth usually bacteriostatic
Disrupt generation of new proteins that are essential for bacteria to
survive
1. Charged tRNA binds to A site
2. Peptidyl tRNA at donor site binds growing amino acid chain to new
amino acid
3. Uncharged tRNA is released and the new chain shifts to P site with the
tRNA
Macrolides:
Erythromycin
Clarithromycin
Azithromycin
Telithromycin
Fidaxomicin
MOA:
1. Bind irreversibly to 50S subunit
2. Inhibit protein synthesis
3. Transpeptidation blockage
4. Bacteriostatic at normal dose; bactericidal at high doses.
They are antimicrobial agents that:
Inhibit bacterial protein synthesis
Act by targeting ribosomes; 30S or 50S
Slow/stop growth usually bacteriostatic
Disrupt generation of new proteins that are essential for bacteria to
survive
1. Charged tRNA binds to A site
2. Peptidyl tRNA at donor site binds growing amino acid chain to new
amino acid
3. Uncharged tRNA is released and the new chain shifts to P site with the
tRNA
Macrolides:
Erythromycin
Clarithromycin
Azithromycin
Telithromycin
Fidaxomicin
MOA:
1. Bind irreversibly to 50S subunit
2. Inhibit protein synthesis
3. Transpeptidation blockage
4. Bacteriostatic at normal dose; bactericidal at high doses.
