NUR 6111 / NUR6111 (2025/2026) Advanced Practice Nursing I Exam
3 – Second Comprehensive Bank: 150 Additional Verified Questions
with Multiple Answers & Detailed Rationales – A Grade A+ Study
Guide for Primary Care, Pathophysiology, and Clinical Management
(Maryville University & William Paterson University)
Below is a second complete set of 150 exam-style questions with verified answers and detailed
rationales, compiled from the latest 2025/2026 NUR 6111 Exam 3 resources for Maryville University
and William Paterson University. This bank covers endocrine, hematologic, gastrointestinal,
dermatologic, infectious disease, and renal topics .
Section 1: Endocrine & Hormonal Regulation (Questions 1–35)
1. What are clinical manifestations of hypothyroidism? (Select all that apply)
A) Constipation
B) Decreased heart rate
C) Lethargy
D) Weight loss
Correct Answers: A, B, C – Hypothyroidism slows metabolism, causing constipation, bradycardia,
fatigue, and weight gain (not loss) .
2. Thyroid-stimulating hormone (TSH) is released to stimulate thyroid hormone (TH) and is
inhibited when plasma levels of TH are adequate. This is an example of:
A) Positive feedback
B) Negative feedback
C) Autocrine signaling
D) Paracrine signaling
Correct Answer: B – Negative feedback occurs when the response negates the initiating change that
triggered hormone release .
3. Lipid-soluble hormone receptors are located:
A) On the cell surface membrane
B) Inside the plasma membrane in the cytoplasm
C) Within the nucleus only
D) On mitochondrial membranes
Correct Answer: B – Lipid-soluble hormones cross cell membranes and bind to intracellular receptors
in the cytoplasm .
4. The releasing hormones that are made in the hypothalamus travel to the anterior pituitary via
the:
,A) Direct neural connection
B) Portal hypophyseal blood vessels
C) Systemic circulation
D) Lymphatic system
Correct Answer: B – The hypothalamic-pituitary portal system delivers releasing hormones directly to
the anterior pituitary .
5. Which mineral is needed for thyroid-stimulating hormone (TSH) to stimulate the secretion of
thyroid hormone (TH)?
A) Iron
B) Iodide
C) Calcium
D) Magnesium
Correct Answer: B – Iodide is essential for thyroid hormone synthesis .
6. What effect does hyperphosphatemia have on other electrolytes?
A) Increases serum calcium
B) Decreases serum calcium
C) No effect on calcium
D) Increases serum potassium
Correct Answer: B – Hyperphosphatemia decreases serum calcium due to reciprocal relationship .
7. Insulin transports which electrolyte into cells?
A) Sodium
B) Potassium
C) Calcium
D) Magnesium
Correct Answer: B – Insulin promotes intracellular potassium uptake .
8. Which second messenger is stimulated by epinephrine binding to a β-adrenergic receptor?
A) Cyclic adenosine monophosphate (cAMP)
B) Cyclic guanosine monophosphate (cGMP)
C) Inositol trisphosphate (IP3)
D) Diacylglycerol (DAG)
Correct Answer: A – Epinephrine binding to β-adrenergic receptors activates adenylyl cyclase,
converting ATP to cAMP .
9. Regulation of the release of catecholamines from the adrenal medulla is an example of which
type of regulation?
A) Hormonal
B) Neural
C) Humoral
D) Autocrine
Correct Answer: B – Stress-induced release of catecholamines from the adrenal medulla is under direct
neural control .
10. Which hormone does the second messenger calcium (Ca++) bind to activate phospholipase C
through a G protein?
, A) Insulin
B) Angiotensin II
C) Cortisol
D) Thyroxine
Correct Answer: B – Ca++ facilitates binding of hormones like angiotensin II to surface receptors,
activating phospholipase C .
11. The control of calcium in cells is important because it:
A) Maintains cell membrane integrity
B) Acts as a second messenger
C) Provides cellular energy
D) Regulates DNA synthesis
Correct Answer: B – Ca++ is an important second messenger in cellular signaling .
12. Where is antidiuretic hormone (ADH) synthesized, and where does it act?
A) Anterior pituitary; collecting ducts
B) Hypothalamus; renal tubular cells
C) Posterior pituitary; loop of Henle
D) Adrenal cortex; glomerulus
Correct Answer: B – ADH is synthesized in the hypothalamus and acts on V2 receptors of renal
collecting duct cells .
13. How does a faulty negative-feedback mechanism result in a hormonal imbalance?
A) Decreased hormone production
B) Excessive hormone production from failure to turn off the system
C) Increased hormone receptor sensitivity
D) Decreased hormone receptor sensitivity
Correct Answer: B – Lack of negative feedback inhibition often results in excessive hormone
production and pathologic conditions .
14. A deficiency of which chemical may result in hypothyroidism?
A) Selenium
B) Iodine
C) Zinc
D) Copper
Correct Answer: B – Endemic iodine deficiency is a cause of hypothyroidism .
15. What imbalance lessens the rate of secretion of parathyroid hormone?
A) Hypocalcemia
B) Hypercalcemia
C) Hyperphosphatemia
D) Hypermagnesemia
Correct Answer: B – The overall effect of PTH is to increase serum calcium; high calcium inhibits PTH
secretion .
16. The level of thyroid-stimulating hormone (TSH) in individuals with Graves disease is usually:
A) High
B) Low
3 – Second Comprehensive Bank: 150 Additional Verified Questions
with Multiple Answers & Detailed Rationales – A Grade A+ Study
Guide for Primary Care, Pathophysiology, and Clinical Management
(Maryville University & William Paterson University)
Below is a second complete set of 150 exam-style questions with verified answers and detailed
rationales, compiled from the latest 2025/2026 NUR 6111 Exam 3 resources for Maryville University
and William Paterson University. This bank covers endocrine, hematologic, gastrointestinal,
dermatologic, infectious disease, and renal topics .
Section 1: Endocrine & Hormonal Regulation (Questions 1–35)
1. What are clinical manifestations of hypothyroidism? (Select all that apply)
A) Constipation
B) Decreased heart rate
C) Lethargy
D) Weight loss
Correct Answers: A, B, C – Hypothyroidism slows metabolism, causing constipation, bradycardia,
fatigue, and weight gain (not loss) .
2. Thyroid-stimulating hormone (TSH) is released to stimulate thyroid hormone (TH) and is
inhibited when plasma levels of TH are adequate. This is an example of:
A) Positive feedback
B) Negative feedback
C) Autocrine signaling
D) Paracrine signaling
Correct Answer: B – Negative feedback occurs when the response negates the initiating change that
triggered hormone release .
3. Lipid-soluble hormone receptors are located:
A) On the cell surface membrane
B) Inside the plasma membrane in the cytoplasm
C) Within the nucleus only
D) On mitochondrial membranes
Correct Answer: B – Lipid-soluble hormones cross cell membranes and bind to intracellular receptors
in the cytoplasm .
4. The releasing hormones that are made in the hypothalamus travel to the anterior pituitary via
the:
,A) Direct neural connection
B) Portal hypophyseal blood vessels
C) Systemic circulation
D) Lymphatic system
Correct Answer: B – The hypothalamic-pituitary portal system delivers releasing hormones directly to
the anterior pituitary .
5. Which mineral is needed for thyroid-stimulating hormone (TSH) to stimulate the secretion of
thyroid hormone (TH)?
A) Iron
B) Iodide
C) Calcium
D) Magnesium
Correct Answer: B – Iodide is essential for thyroid hormone synthesis .
6. What effect does hyperphosphatemia have on other electrolytes?
A) Increases serum calcium
B) Decreases serum calcium
C) No effect on calcium
D) Increases serum potassium
Correct Answer: B – Hyperphosphatemia decreases serum calcium due to reciprocal relationship .
7. Insulin transports which electrolyte into cells?
A) Sodium
B) Potassium
C) Calcium
D) Magnesium
Correct Answer: B – Insulin promotes intracellular potassium uptake .
8. Which second messenger is stimulated by epinephrine binding to a β-adrenergic receptor?
A) Cyclic adenosine monophosphate (cAMP)
B) Cyclic guanosine monophosphate (cGMP)
C) Inositol trisphosphate (IP3)
D) Diacylglycerol (DAG)
Correct Answer: A – Epinephrine binding to β-adrenergic receptors activates adenylyl cyclase,
converting ATP to cAMP .
9. Regulation of the release of catecholamines from the adrenal medulla is an example of which
type of regulation?
A) Hormonal
B) Neural
C) Humoral
D) Autocrine
Correct Answer: B – Stress-induced release of catecholamines from the adrenal medulla is under direct
neural control .
10. Which hormone does the second messenger calcium (Ca++) bind to activate phospholipase C
through a G protein?
, A) Insulin
B) Angiotensin II
C) Cortisol
D) Thyroxine
Correct Answer: B – Ca++ facilitates binding of hormones like angiotensin II to surface receptors,
activating phospholipase C .
11. The control of calcium in cells is important because it:
A) Maintains cell membrane integrity
B) Acts as a second messenger
C) Provides cellular energy
D) Regulates DNA synthesis
Correct Answer: B – Ca++ is an important second messenger in cellular signaling .
12. Where is antidiuretic hormone (ADH) synthesized, and where does it act?
A) Anterior pituitary; collecting ducts
B) Hypothalamus; renal tubular cells
C) Posterior pituitary; loop of Henle
D) Adrenal cortex; glomerulus
Correct Answer: B – ADH is synthesized in the hypothalamus and acts on V2 receptors of renal
collecting duct cells .
13. How does a faulty negative-feedback mechanism result in a hormonal imbalance?
A) Decreased hormone production
B) Excessive hormone production from failure to turn off the system
C) Increased hormone receptor sensitivity
D) Decreased hormone receptor sensitivity
Correct Answer: B – Lack of negative feedback inhibition often results in excessive hormone
production and pathologic conditions .
14. A deficiency of which chemical may result in hypothyroidism?
A) Selenium
B) Iodine
C) Zinc
D) Copper
Correct Answer: B – Endemic iodine deficiency is a cause of hypothyroidism .
15. What imbalance lessens the rate of secretion of parathyroid hormone?
A) Hypocalcemia
B) Hypercalcemia
C) Hyperphosphatemia
D) Hypermagnesemia
Correct Answer: B – The overall effect of PTH is to increase serum calcium; high calcium inhibits PTH
secretion .
16. The level of thyroid-stimulating hormone (TSH) in individuals with Graves disease is usually:
A) High
B) Low
