WGU D027 FINAL EXAM SCRIPT – ACTUAL EXAM QUESTIONS AND CORRECT DETAILED SOLUTIONS (LATEST UPDATE)

Prepare for the WGU D027 Objective Assessment final exam with this actual exam script. Contains real exam questions with correct detailed solutions, latest update. Covers all key pharmacology and pathophysiology topics: antiepileptic drug therapy monitoring with serum drug levels, aspirin discontinuation one week before surgery, glucocorticoid bone loss prevention with calcium/vitamin D, methotrexate for rheumatoid arthritis delaying joint destruction, urate-lowering drugs for gout flare prevention, colchicine for acute gout, estrogen therapy benefits for menopause and bone loss, estrogen-only HRT post-hysterectomy, IUD contraindications with multiple sex partners, terazosin for BPH improving urinary hesitation, metronidazole alcohol avoidance, bulk-forming laxatives with full glass of water, glipizide-TMP/SMX interaction causing hypoglycemia, primary UTI treatment with Bactrim 3 days, herpes treatment acyclovir/valacyclovir, hydroxyzine alcohol avoidance, hypertension diagnosis 2 readings on 2 separate visits, stable COPD management with inhaled glucocorticoid for prevention and beta2-agonist PRN, LABA for stable COPD, guaifenesin for productive cough, alpha-adrenergic antagonist first dose at bedtime to prevent orthostatic hypotension, Parkinson disease levodopa/carbidopa tics managed with lower dose, Alzheimer’s risk factors age and family history, phenytoin interaction with oral contraceptives pregnancy category D, atorvastatin for LDL cholesterol lowering, CHF with low EF and elevated BNP switch from ACE/ARB to ARNI (Entresto), beta-blockers contraindicated in COPD/asthma due to bronchospasm, type 2 diabetes 90-95%, kava monitoring liver function for anxiety/insomnia, most common childhood cancer leukemia 85% cure rate, aging thyroid gland changes, appetite stimulating hormones orexigenic signals, hot flashes from decreased estrogen, cardiovascular aging left ventricular hypertrophy, ACE inhibitors avoid in sexually active females, asthma diagnosis spirometry, PEN-3 model domains cultural identity relationships expectations empowerment, suicide attempt rate for transgender individuals 48%, metformin Ramadan dosing decrease dose change to XR, red yeast rice avoid with lovastatin, adults receive 55% of recommended clinical services, poor HgbA1c control 9%, cervical cancer screening 20-29 every 3 years, CURB-65 score 3 or greater for pneumonia admission, LDL goal below 70, chronic steroids inhibit growth in children, caffeine increases seizure risk, methylphenidate (Ritalin) measure height and weight before starting, live vaccine varicella, ACE inhibitor examples lisinopril and -ril drugs, learned pain response in cerebral cortex, enkephalins and endorphins attach to opiate receptor sites, imitrex contraindicated in CAD for migraines, supplemental oxygen for cluster headaches, acupuncture for cancer pain unclear effectiveness, panic disorder complication agoraphobia, anxiety diagnosis requires 6 months, FGA-induced parkinsonism treated with anticholinergic medications, SSRI side effects GI disturbances, stress hormone cortisol, exhaustion stage of adaptation if unsuccessful, adaptive stage of GAS patient perceives fight or flight, NK cell reduction correlates with depression, PTSD diagnosis after 4 weeks, first-line acute stress disorder cognitive behavior therapy, cymbalta interaction with tramadol, Alzheimer’s plaques and tangles, average lifespan 4-8 years, first-line Alzheimer’s treatment cholinesterase inhibitors (donepezil, galantamine, rivastigmine), moderate to severe Alzheimer’s Namenda or Namenda with donepezil, rivastigmine for mild to moderate Alzheimer’s dementia and Parkinson’s, Namenda regulates glutamate activity, ataxia degenerative nervous system disorder mimics drunkenness from cerebellum or spinal cord damage, celiac disease loss of mucosal surface area in duodenum and jejunum, celiac symptoms rickets abdominal pain occult blood anemia diarrhea bruising, celiac diagnosis duodenal biopsy IgA antibodies or HLA-DQ2/DQ8, atopic dermatitis and eczema increased risk of inflammatory bowel disease, Crohn’s labs ASCA antibodies CBC CRP heme-occult LFT iron B12, Crohn’s diagnosis KUB endoscopy barium colonoscopy CT/MRI capsule endoscopy, mild Crohn’s oral aminosalicylate, moderate Crohn’s increased aminosalicylate and oral steroids, severe Crohn’s IV steroids, aminosalicylates sulfasalazine reduce inflammation, corticosteroids prednisone not first choice, immunosuppressants azathioprine cyclosporine tacrolimus methotrexate, biologics Remicade for Crohn’s, Crohn’s diet low residue low fiber low fat, color blindness affects retinal cones red/green most common, OPN1MW gene, COPD diagnosis spirometry PFT, first-line COPD short-acting bronchodilators, theophylline relaxes airway smooth muscle, vaccines contraindicated in pregnancy HPV live influenza MMR varicella zoster, Tdap given 27-36 weeks pregnancy, neuropathic pain treatment amitriptyline gabapentin Lyrica pregabalin, otitis media middle ear infection 80% by age 3, first-line amoxicillin or augmentin, ginkgo biloba or garlic with anticoagulants increases bleeding risk, combined contraceptives avoid while breastfeeding, cinnamon used for diabetes, Florinef for Addison’s disease and salt-losing adrenogenital syndrome with GI headache skin changes dizziness, prazosin off-label for BPH and PTSD sleep aid, ACE inhibitor first-line for diabetic hypertension with dry cough hyperkalemia side effects, avoid ARB with ACE inhibitor, asthma step therapy SABA PRN step 1, step 2 low dose ICS, step 3 low dose ICS + LABA or medium dose ICS, step 4 medium dose ICS + LABA, step 5 high dose ICS + LABA, step 6 high dose ICS + LABA + oral corticosteroid, myasthenia gravis autoimmune blocking acetylcholine receptors, treatment cholinesterase inhibitors and corticosteroids, thyrotoxic crisis/thyroid storm from severe untreated hyperthyroidism with stress, symptoms hyperthermia tachycardia atrial dysrhythmias heart failure agitation vomiting, treatment PTU or methimazole beta-blockers corticosteroids iodine plasma exchange thyroidectomy, hypothyroidism high TSH low T3/T4, hyperthyroidism low TSH high T3/T4, Hashimoto most common hypothyroidism with TPO and Tg antibodies, Graves most common hyperthyroidism with TPO antibodies, medullary thyroid cancer from C cells increased calcitonin and CEA, RET oncogene chromosome 10 hereditary mutation all cells vs sporadic tumor cells only, POTS criteria HR increase 30+ bpm within 10 minutes standing no orthostatic hypotension, tilt table test, 25% of POTS patients disabled, POTS quality of life comparable to dialysis, buspirone less addictive anxiety medication, left hypoplastic heart defect, G6PD deficiency X-linked recessive in African/Mediterranean males, avoid fava beans aspirin wine blueberries soy tonic water camphor, IgM reaction treatment slow infusion Tylenol Benadryl steroids, rigors treated with Demerol, ejection fraction 50% preserved, small cell lung carcinoma worst prognosis neuroendocrine tumor 15% of lung cancers 25% of deaths, paraneoplastic syndromes hyponatremia hypocalcemia carcinoid, nystatin for infant thrush 10 days, diflucan if nystatin fails, PPD read 48-72 hours 10mm positive, chest x-ray for prior TB immunization, celiac testing IgA-TTG, kidneys release erythropoietin in hypoxemia, ACE inhibitors avoid in pregnancy use ARB, metoprolol with nifedipine prevents reflex tachycardia, beta-blocker for 6 months post-MI, beta-blockers and calcium channel blockers have nearly identical cardiac effects, simvastatin with azithromycin muscle pain concern, protamine sulfate for heparin reversal, vitamin K for warfarin reversal, Lantus given at bedtime, normal T4 5-12, normal T3 80-220, elevated T3 indicates hyperthyroidism treated with PTU, untreated hypothyroidism in pregnancy causes fetal neuropsychological deficits, iodine-131 destroys thyroid cells for Graves disease, metered dose inhaler wait 1 minute between puffs, stage 1 HTN SBP 130-139 or DBP 80-89, stage 2 HTN SBP ≥140 or DBP ≥90, social determinants of health economic stability employment food insecurity housing poverty, education early childhood education high school graduation literacy, social and community context civic participation discrimination incarceration, health and health care access to primary care health literacy, neighborhood and built environment access to healthy foods crime violence housing quality, alpha thalassemia inherited mild to severe anemia, beta thalassemia Mediterranean North African Italian Greek with anemia symptoms growth delays, beta thalassemia treatment regular blood transfusions erythropoietin, depression diagnosis requires 2 weeks, first-line antidepressants SSRIs MAOIs TCAs or psychotherapy 2-4 weeks to work, G6PD most common problem hemolytic anemia, myasthenia gravis chronic autoimmune neuromuscular weakness worsened with activity, plasmapheresis IVIG thymectomy anticholinesterase immunosuppressants for myasthenia gravis, parathyroid hormone maintains calcium balance, hyperparathyroidism symptoms hypercalcemia fatigue bone pain kidney stones treated with calcimetics bisphosphonates, hypoparathyroidism control diet maintain slightly low calcium, most common UTI bacteria E. coli, Hutchinson-Gilford progeria syndrome LMNA mutation rapid aging statins NSAIDs, schizophrenia thought disorders positive negative cognitive categories, anhedonia unable to feel emotions, alogia absence of spontaneous speech, avolition deficit in goal-directed behavior, antipsychotics and CBT for schizophrenia, small cell lung cancer worst prognosis 8% 5-year survival, antidiuretic hormone causes hyponatremia, ACTH causes Cushing syndrome, calcitonin causes hypocalcemia, gonadotropin causes gynecomastia, serotonin causes carcinoid syndrome, athletic heart syndrome enlarged heart lower resting heart rate, TB treatment isoniazid rifampin ethambutol pyrazinamide. Essential for WGU D027 nursing pharmacology and pathophysiology final exam success.