IPS2: PHARMACOLOGY: TEST 5 QUESTIONS WITH ACCURATE
ANSWERS.
1) If a patient was poisoned by heparin at 2000 IU, how many protamine sulphate
(IV) must be administered?
A) 10 mg
B) 15 mg
C) 20 mg
D) 25 mg -- Correct Answer ✔✔ c. 20 mg
2) Warfarin means:
A) Washington Alumni Research Foundation coumarin
B) Winnipeg Alumni Research Foundation coumarin
C) Warsaw Alumni Research Foundation coumarin
D) Wisconsin Alumni Research Foundation coumarin -- Correct
Answer ✔✔ d. Wisconsin Alumni Research Foundation coumarin
3) Which of the following clotting factors is not inhibited by warfarin?
, A) Factor III
B) Factor X
C) Factor IX
D) Factor VII -- Correct Answer ✔✔ a. Factor III
4) Initially, the effect of warfarin is anticoagulation. This is because warfarin inhibits
endogenous anticoagulants, such as Protein C and Protein S.
A) First statement is TRUE; the second is FALSE
B) First statement is FALSE; the second is TRUE
C) Both statements are TRUE
D) Both statements are FALSE -- Correct Answer ✔✔ b. First
statement is FALSE; the second is TRUE
5) Monitoring of warfarin is through:
A) PT-INR
B) aPTT
C) No monitoring is required
D) All of the above -- Correct Answer ✔✔ a. PT-INR
6) For most patients, the desired value range of PT-INR is:
A) 2-3
B) 2.5-3.5
C) 3-4
D) 1-2 -- Correct Answer ✔✔ a. 2-3
7) The PT-INR of a patient on Warfarin has been maintained at 2.5 for the last 3
months. One week earlier, the patient was given Phenobarbital. What can be
expected with the PT-INR of the patient?
, A) Increased PT-INR
B) Decreased PT-INR
C) Maintained PT-INR
D) All of the above -- Correct Answer ✔✔ b. Decreased PT-INR
8) Cutaneous necrosis is an initial side effect brought by warfarin if it is not
combined with:
A) Heparin
B) Sulfinpyrazone
C) Vitamin K
D) Aspirin -- Correct Answer ✔✔ a. Heparin
9) Teratogenic effect of warfarin on the third trimester of pregnancy:
A) Nasal hypoplasia and depressed nasal bridge
B) Increased risk of fetal CNS malformations
C) Hemorrhagic disease of the newborn
D) All of the above -- Correct Answer ✔✔ c. Hemorrhagic disease of
the newborn
10) Purple toe syndrome is a toxicity induced by which anticoagulant?
A) Heparin
B) Warfarin
C) Enoxaparin
D) Ticlopidine -- Correct Answer ✔✔ b. Warfarin
11) This specific type of vitamin K is used to reverse the action of warfarin during
toxicity:
A) Phytonadione
ANSWERS.
1) If a patient was poisoned by heparin at 2000 IU, how many protamine sulphate
(IV) must be administered?
A) 10 mg
B) 15 mg
C) 20 mg
D) 25 mg -- Correct Answer ✔✔ c. 20 mg
2) Warfarin means:
A) Washington Alumni Research Foundation coumarin
B) Winnipeg Alumni Research Foundation coumarin
C) Warsaw Alumni Research Foundation coumarin
D) Wisconsin Alumni Research Foundation coumarin -- Correct
Answer ✔✔ d. Wisconsin Alumni Research Foundation coumarin
3) Which of the following clotting factors is not inhibited by warfarin?
, A) Factor III
B) Factor X
C) Factor IX
D) Factor VII -- Correct Answer ✔✔ a. Factor III
4) Initially, the effect of warfarin is anticoagulation. This is because warfarin inhibits
endogenous anticoagulants, such as Protein C and Protein S.
A) First statement is TRUE; the second is FALSE
B) First statement is FALSE; the second is TRUE
C) Both statements are TRUE
D) Both statements are FALSE -- Correct Answer ✔✔ b. First
statement is FALSE; the second is TRUE
5) Monitoring of warfarin is through:
A) PT-INR
B) aPTT
C) No monitoring is required
D) All of the above -- Correct Answer ✔✔ a. PT-INR
6) For most patients, the desired value range of PT-INR is:
A) 2-3
B) 2.5-3.5
C) 3-4
D) 1-2 -- Correct Answer ✔✔ a. 2-3
7) The PT-INR of a patient on Warfarin has been maintained at 2.5 for the last 3
months. One week earlier, the patient was given Phenobarbital. What can be
expected with the PT-INR of the patient?
, A) Increased PT-INR
B) Decreased PT-INR
C) Maintained PT-INR
D) All of the above -- Correct Answer ✔✔ b. Decreased PT-INR
8) Cutaneous necrosis is an initial side effect brought by warfarin if it is not
combined with:
A) Heparin
B) Sulfinpyrazone
C) Vitamin K
D) Aspirin -- Correct Answer ✔✔ a. Heparin
9) Teratogenic effect of warfarin on the third trimester of pregnancy:
A) Nasal hypoplasia and depressed nasal bridge
B) Increased risk of fetal CNS malformations
C) Hemorrhagic disease of the newborn
D) All of the above -- Correct Answer ✔✔ c. Hemorrhagic disease of
the newborn
10) Purple toe syndrome is a toxicity induced by which anticoagulant?
A) Heparin
B) Warfarin
C) Enoxaparin
D) Ticlopidine -- Correct Answer ✔✔ b. Warfarin
11) This specific type of vitamin K is used to reverse the action of warfarin during
toxicity:
A) Phytonadione
