OB/GYN - 2nd Exam Actual Questions
and Answers 2026
The majority of endometrial cancer arise from where? -
correct answer ✅The glands of the endometrium
Where is the least common origin of endometrial cancer located? -
correct answer ✅From a mesenchymal uterine component such as
a
sarcoma
When women are treated for breast cancer with tamoxifen how
many more times are they likely to get endometrial cancer? -
correct answer ✅7 times more likely
How do patients get treated differently when they are on
tamoxifen? -
correct answer ✅They get screened more often and endometrial
biopsies are done serially in order to obtain early detection (over 5
years)
How long is considered "long term" use of OCP containing
estrogen? -
correct answer ✅More than 2-3 years
,OB/GYN - 2nd Exam Actual Questions
and Answers 2026
What is the only group of women that should ever be prescribed
estrogen without progesterone? -
correct answer ✅A woman without a uterus
What is the MC precursor to endometrial cancer? -
correct answer ✅Endometrial hyperplasia
There are 4 types of endometrial hyperplasia, what are they? -
correct answer ✅Simple hyperplagia
Complex hyperplagia
Simple Hyperplasia with cytological atypia
Complex Hyperplasia with cytological atypia
What is unique about simple hyperplasia? -
correct answer ✅It has stromal and glandular components that
proliferate excessively
Stage three endometrial cancer has been reported for your patient,
where is their cancer located? -
correct answer ✅In the outside the myometrium but not the
bladder, bowel, abdomen, inguinal lymph nodes
,OB/GYN - 2nd Exam Actual Questions
and Answers 2026
What percent of endometrial cancer is estrogen dependent? -
correct answer ✅90%, these are type I cancer
This group of patient is more likely to get type I endometrial
cancer? -
correct answer ✅Younger, perimenopausal women
*These cancers are low-grade (well differentiated tumor with
favorable prognosis)
Older postmenopausal woman are most likely to get this type of
endometrial cancer? -
correct answer ✅Type II Estrogen independent
*This occurs spontaneously usually from endometrial atrophy. It
has high risk of relapse with poor prognosis
How will patients with endometrial cancer present? -
correct answer ✅They will describe feeling of cramps, vaginal
bleeding, or a tender lower abdomen
What are some common causes for an increase in estrogen
present? -
correct answer ✅Metabolic syndrome
, OB/GYN - 2nd Exam Actual Questions
and Answers 2026
Polycystic Ovarian Syndrome (PCOS)
Chronic anovulation in premenopausal women
HRT without progestin (exogenous)
Granulosa cell tumors (rare)
Tamoxifen (weak estrogenic effect) increases E.C. 2-3 fold
What are the two type of non-estrogen dependent endometrial
cancers? -
correct answer ✅Serous adenocarcinoma
Clear adenocarcinoma
Who do the non-estrogen dependent endometrial cancers affect? -
correct answer ✅Women in 60s and 70s
A endometrial biopsy MUST be done on a woman in her 60s and
70s if what occurs? -
correct answer ✅She reports a single drop of blood present.
What are two reasons you would do a hysteroscopy on a patient
instead of an EMB? -
correct answer ✅Stenotic cervical os
and Answers 2026
The majority of endometrial cancer arise from where? -
correct answer ✅The glands of the endometrium
Where is the least common origin of endometrial cancer located? -
correct answer ✅From a mesenchymal uterine component such as
a
sarcoma
When women are treated for breast cancer with tamoxifen how
many more times are they likely to get endometrial cancer? -
correct answer ✅7 times more likely
How do patients get treated differently when they are on
tamoxifen? -
correct answer ✅They get screened more often and endometrial
biopsies are done serially in order to obtain early detection (over 5
years)
How long is considered "long term" use of OCP containing
estrogen? -
correct answer ✅More than 2-3 years
,OB/GYN - 2nd Exam Actual Questions
and Answers 2026
What is the only group of women that should ever be prescribed
estrogen without progesterone? -
correct answer ✅A woman without a uterus
What is the MC precursor to endometrial cancer? -
correct answer ✅Endometrial hyperplasia
There are 4 types of endometrial hyperplasia, what are they? -
correct answer ✅Simple hyperplagia
Complex hyperplagia
Simple Hyperplasia with cytological atypia
Complex Hyperplasia with cytological atypia
What is unique about simple hyperplasia? -
correct answer ✅It has stromal and glandular components that
proliferate excessively
Stage three endometrial cancer has been reported for your patient,
where is their cancer located? -
correct answer ✅In the outside the myometrium but not the
bladder, bowel, abdomen, inguinal lymph nodes
,OB/GYN - 2nd Exam Actual Questions
and Answers 2026
What percent of endometrial cancer is estrogen dependent? -
correct answer ✅90%, these are type I cancer
This group of patient is more likely to get type I endometrial
cancer? -
correct answer ✅Younger, perimenopausal women
*These cancers are low-grade (well differentiated tumor with
favorable prognosis)
Older postmenopausal woman are most likely to get this type of
endometrial cancer? -
correct answer ✅Type II Estrogen independent
*This occurs spontaneously usually from endometrial atrophy. It
has high risk of relapse with poor prognosis
How will patients with endometrial cancer present? -
correct answer ✅They will describe feeling of cramps, vaginal
bleeding, or a tender lower abdomen
What are some common causes for an increase in estrogen
present? -
correct answer ✅Metabolic syndrome
, OB/GYN - 2nd Exam Actual Questions
and Answers 2026
Polycystic Ovarian Syndrome (PCOS)
Chronic anovulation in premenopausal women
HRT without progestin (exogenous)
Granulosa cell tumors (rare)
Tamoxifen (weak estrogenic effect) increases E.C. 2-3 fold
What are the two type of non-estrogen dependent endometrial
cancers? -
correct answer ✅Serous adenocarcinoma
Clear adenocarcinoma
Who do the non-estrogen dependent endometrial cancers affect? -
correct answer ✅Women in 60s and 70s
A endometrial biopsy MUST be done on a woman in her 60s and
70s if what occurs? -
correct answer ✅She reports a single drop of blood present.
What are two reasons you would do a hysteroscopy on a patient
instead of an EMB? -
correct answer ✅Stenotic cervical os
