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The activation of N-methyl-d-aspartate (NMDA) receptors requires the presence of:
A. Glutamate only
B. Glutamate and glycine.
C. Glutamate, glycine and magnesium. - CORRECT ANSWER -B. Glutamate and glycine
A leading hypothesis of psychosis is:
A. Hyperfunctioning NMDA receptors.
B. Hypofunctioning NMDA receptors. - CORRECT ANSWER -Hypofunctioning NMDA
receptors
Dysfunction at NMDA-receptor containing synapses is hypothesized to lead to excessive
glutamate release in the ventral tegmental area. Downstream this is hypothesized to lead to what
effects on dopamine (DA):
A. Excessive DA release in the nucleus accumbens (NA) and excessive DA release in the
prefrontal cortex (PC)
B. Reduced DA release in the NA and reduced DA release in the PFC
C. Excessive DA release in the NA and reduced DA release in the PFC
D.Reduced DA release in the NA and excessive DA release in the PFC. - CORRECT ANSWER -
C. Excessive DA release in the NA and reduced DA release in the PFC.
The neurodevelopmental hypothesis of schizophrenia centers heavily around the idea that
aberrant competitive elimination occurs. Competitive elimination is a stage of neurodevelopment
in which:
A. Embryonic stem cells either die or differentiate into immature neurons.
B. Newly sprouted axons compete with each other to form synaptic connections at dendrites.