Georgette Review PMHNP EXAM
LATEST 2026-2027 QUESTIONS AND
100% Verified ANSWERS.
SECTION 1: NEUROBIOLOGY & NEUROTRANSMITTERS (Qs 1–15)
1. What is the best treatment for AIDS dementia complex?
Answer: Antiretroviral therapy
2. Which neurotransmitter system is primarily implicated in the pathophysiology of
Parkinson’s disease?
Answer: Dopamine
3. The monoamine hypothesis of depression suggests deficiencies in which three
neurotransmitters?
Answer: Dopamine, norepinephrine, serotonin (DNS)
4. Which brain structure is most associated with fear conditioning and anxiety
disorders?
Answer: Amygdala
5. In ADHD, abnormalities are most commonly found in which brain regions?
Answer: Frontal cortex, basal ganglia, and reticular activating system
6. The phenomenon where repeated exposure to a substance leads to decreased
effect of the same dose is called:
Answer: Tolerance
7. Kindling refers to:
Answer: Tendency of some brain regions to react to repeated low-level
bioelectrical stimulation by progressively boosting synaptic discharges,
lowering seizure threshold (e.g., alcohol and benzodiazepines)
,8. Which neurotransmitter is the primary target of medications for Tourette’s
disorder?
Answer: Dopamine (antagonists)
9. The default mode network (DMN) is hyperactive in which disorder?
Answer: Major depressive disorder and Alzheimer’s disease
10. Which amino acid is the primary excitatory neurotransmitter in the brain?
Answer: Glutamate
11. Which amino acid is the primary inhibitory neurotransmitter in the brain?
Answer: GABA (gamma-aminobutyric acid)
12. In PTSD, which brain structure shows reduced volume on neuroimaging?
Answer: Hippocampus
13. Acetylcholinesterase inhibitors are used primarily in which disorder?
Answer: Alzheimer’s dementia
14. The mesolimbic pathway is most associated with which function?
Answer: Reward and motivation (dopamine pathway)
15. Serotonin is synthesized from which amino acid?
Answer: Tryptophan
SECTION 2: PREVENTION & PUBLIC HEALTH (Qs 16–25)
16. Aimed at decreasing the number of new cases – this is which level of
prevention?
Answer: Primary prevention
17. Any form of screening is what level of prevention?
Answer: Secondary prevention
18. Aimed at decreasing disability and severity of an existing condition – this is
which level of prevention?
Answer: Tertiary prevention
19. Providing rehabilitation services after a stroke is an example of:
Answer: Tertiary prevention
, 20. Vaccination programs are an example of:
Answer: Primary prevention
21. Early intervention programs for first-episode psychosis are an example of:
Answer: Secondary prevention
22. Universal prevention targets:
Answer: The general population regardless of risk
23. Indicated prevention targets:
Answer: High-risk individuals with minimal but detectable signs
24. A suicide prevention hotline is an example of:
Answer: Secondary prevention
25. Medication maintenance for bipolar disorder to prevent relapse is:
Answer: Tertiary prevention
SECTION 3: ADHD – DIAGNOSIS & ASSESSMENT (Qs 26–45)
26. What are the hallmarks of ADHD?
Answer: Persistent pattern of inattention and/or hyperactivity-impulsivity
27. What should be checked prior to prescribing a stimulant?
Answer: Cardiac history, family history of cardiovascular disease, and obtain
an EKG
28. Amphetamines are approved for use in children as young as:
Answer: 3 years old
29. Signs of stimulant abuse include:
Answer: Insomnia, tremors, heart palpitations, increased BP and HR
30. Name two validated rating scales for ADHD.
Answer: Conners Rating Scales and Vanderbilt Assessment Scales
31. For an ADHD diagnosis, symptoms must be present in how many settings?
Answer: At least two settings (e.g., home and school)
32. What is the minimum duration of symptoms for ADHD diagnosis in adults?
Answer: 6 months with onset before age 12
LATEST 2026-2027 QUESTIONS AND
100% Verified ANSWERS.
SECTION 1: NEUROBIOLOGY & NEUROTRANSMITTERS (Qs 1–15)
1. What is the best treatment for AIDS dementia complex?
Answer: Antiretroviral therapy
2. Which neurotransmitter system is primarily implicated in the pathophysiology of
Parkinson’s disease?
Answer: Dopamine
3. The monoamine hypothesis of depression suggests deficiencies in which three
neurotransmitters?
Answer: Dopamine, norepinephrine, serotonin (DNS)
4. Which brain structure is most associated with fear conditioning and anxiety
disorders?
Answer: Amygdala
5. In ADHD, abnormalities are most commonly found in which brain regions?
Answer: Frontal cortex, basal ganglia, and reticular activating system
6. The phenomenon where repeated exposure to a substance leads to decreased
effect of the same dose is called:
Answer: Tolerance
7. Kindling refers to:
Answer: Tendency of some brain regions to react to repeated low-level
bioelectrical stimulation by progressively boosting synaptic discharges,
lowering seizure threshold (e.g., alcohol and benzodiazepines)
,8. Which neurotransmitter is the primary target of medications for Tourette’s
disorder?
Answer: Dopamine (antagonists)
9. The default mode network (DMN) is hyperactive in which disorder?
Answer: Major depressive disorder and Alzheimer’s disease
10. Which amino acid is the primary excitatory neurotransmitter in the brain?
Answer: Glutamate
11. Which amino acid is the primary inhibitory neurotransmitter in the brain?
Answer: GABA (gamma-aminobutyric acid)
12. In PTSD, which brain structure shows reduced volume on neuroimaging?
Answer: Hippocampus
13. Acetylcholinesterase inhibitors are used primarily in which disorder?
Answer: Alzheimer’s dementia
14. The mesolimbic pathway is most associated with which function?
Answer: Reward and motivation (dopamine pathway)
15. Serotonin is synthesized from which amino acid?
Answer: Tryptophan
SECTION 2: PREVENTION & PUBLIC HEALTH (Qs 16–25)
16. Aimed at decreasing the number of new cases – this is which level of
prevention?
Answer: Primary prevention
17. Any form of screening is what level of prevention?
Answer: Secondary prevention
18. Aimed at decreasing disability and severity of an existing condition – this is
which level of prevention?
Answer: Tertiary prevention
19. Providing rehabilitation services after a stroke is an example of:
Answer: Tertiary prevention
, 20. Vaccination programs are an example of:
Answer: Primary prevention
21. Early intervention programs for first-episode psychosis are an example of:
Answer: Secondary prevention
22. Universal prevention targets:
Answer: The general population regardless of risk
23. Indicated prevention targets:
Answer: High-risk individuals with minimal but detectable signs
24. A suicide prevention hotline is an example of:
Answer: Secondary prevention
25. Medication maintenance for bipolar disorder to prevent relapse is:
Answer: Tertiary prevention
SECTION 3: ADHD – DIAGNOSIS & ASSESSMENT (Qs 26–45)
26. What are the hallmarks of ADHD?
Answer: Persistent pattern of inattention and/or hyperactivity-impulsivity
27. What should be checked prior to prescribing a stimulant?
Answer: Cardiac history, family history of cardiovascular disease, and obtain
an EKG
28. Amphetamines are approved for use in children as young as:
Answer: 3 years old
29. Signs of stimulant abuse include:
Answer: Insomnia, tremors, heart palpitations, increased BP and HR
30. Name two validated rating scales for ADHD.
Answer: Conners Rating Scales and Vanderbilt Assessment Scales
31. For an ADHD diagnosis, symptoms must be present in how many settings?
Answer: At least two settings (e.g., home and school)
32. What is the minimum duration of symptoms for ADHD diagnosis in adults?
Answer: 6 months with onset before age 12
