MSN 671 STUDY GUIDE WITH COMPLETE
SOLUTIONS
Presynaptic reuptake transporters are a major method of inactivation of which of the following -
CORRECT ANSWER -serotonin and GABA
What is constitutive activity - CORRECT ANSWER -signal transduction when no agonist or inverse
agonist is bound to the receptor
a partial agonist has what effect on neurotransmission - CORRECT ANSWER -net agonism when
neurotransmission is deficient and net antagonism when neurotransmission is excessive
Agonists cause ligand-gated ion channels to: - CORRECT ANSWER -
positive and negative allosteric modulations - CORRECT ANSWER -both are only possible in the
presence of a neurotransmitter
When voltage-sensitive sodium channels are open and activated, the flow of sodium is: A. Into
the neuron B. Out of the neuron - CORRECT ANSWER -into the neuron
which of the following are involved in regulating neurotransmission via excitation-secretion
coupling? - CORRECT ANSWER -voltage-sensitive sodium channels
voltage-sensitive calcium channels
A 21-year-old man who has just been diagnosed with schizo presents with his parents. He
speaks with a reserved and simple language processing style; he is able to understand and
relate to simple questions but seems to get lost when the pace of convo increases. when
reviewing the patient's history, what pattern of cognitive functioning prior to psychosis would
, you be most likely to find? - CORRECT ANSWER -impaired cognitive functioning premorbidly
with further decline during the prodromal phase
DA receptors can be categorized as D1-like (D1 and D5 receptors) and D2-like (D2, D3, and D4
receptors). What differentiates the two group of receptors. - CORRECT ANSWER -D1-like
receptors are excitatory and D2-like receptors are inhibitory
Symptoms of schizophrenia are hypothetically attributable to malfunctioning in the - CORRECT
ANSWER -mesocortical and mesolimbic pathways
for which set of disorder is psychosis considered an associated feature rather than a defining
feature for diagnosis? - CORRECT ANSWER -Bipolar mania, Parkinson's disease
The activation of N-methyl-d-aspartate (NMDA) receptors requires the presence of:
A. Glutamate only
. Glutamate and glycine
C. Glutamate, glycine, and magnesium
D. Glutamate and magnesium - CORRECT ANSWER -glutamate and glycine
a leading hypothesis of psychosis is - CORRECT ANSWER -hypo functioning NMDA receptors
dysfunction at NMDA-receptor containing synapses is hypothesized to lead to excessive
glutamate release in the ventral tegmental area. Downstream, this is hypothesized to lead to
what effects on dopamine (DA)? - CORRECT ANSWER -excessive DA release in the NA and
reduced DA release in the PFC
the neurodevelopmental hypothesis of schizophrenia centers heavily around the idea that
aberrant competitive elimination occurs. Competitive elimination is a stage of
SOLUTIONS
Presynaptic reuptake transporters are a major method of inactivation of which of the following -
CORRECT ANSWER -serotonin and GABA
What is constitutive activity - CORRECT ANSWER -signal transduction when no agonist or inverse
agonist is bound to the receptor
a partial agonist has what effect on neurotransmission - CORRECT ANSWER -net agonism when
neurotransmission is deficient and net antagonism when neurotransmission is excessive
Agonists cause ligand-gated ion channels to: - CORRECT ANSWER -
positive and negative allosteric modulations - CORRECT ANSWER -both are only possible in the
presence of a neurotransmitter
When voltage-sensitive sodium channels are open and activated, the flow of sodium is: A. Into
the neuron B. Out of the neuron - CORRECT ANSWER -into the neuron
which of the following are involved in regulating neurotransmission via excitation-secretion
coupling? - CORRECT ANSWER -voltage-sensitive sodium channels
voltage-sensitive calcium channels
A 21-year-old man who has just been diagnosed with schizo presents with his parents. He
speaks with a reserved and simple language processing style; he is able to understand and
relate to simple questions but seems to get lost when the pace of convo increases. when
reviewing the patient's history, what pattern of cognitive functioning prior to psychosis would
, you be most likely to find? - CORRECT ANSWER -impaired cognitive functioning premorbidly
with further decline during the prodromal phase
DA receptors can be categorized as D1-like (D1 and D5 receptors) and D2-like (D2, D3, and D4
receptors). What differentiates the two group of receptors. - CORRECT ANSWER -D1-like
receptors are excitatory and D2-like receptors are inhibitory
Symptoms of schizophrenia are hypothetically attributable to malfunctioning in the - CORRECT
ANSWER -mesocortical and mesolimbic pathways
for which set of disorder is psychosis considered an associated feature rather than a defining
feature for diagnosis? - CORRECT ANSWER -Bipolar mania, Parkinson's disease
The activation of N-methyl-d-aspartate (NMDA) receptors requires the presence of:
A. Glutamate only
. Glutamate and glycine
C. Glutamate, glycine, and magnesium
D. Glutamate and magnesium - CORRECT ANSWER -glutamate and glycine
a leading hypothesis of psychosis is - CORRECT ANSWER -hypo functioning NMDA receptors
dysfunction at NMDA-receptor containing synapses is hypothesized to lead to excessive
glutamate release in the ventral tegmental area. Downstream, this is hypothesized to lead to
what effects on dopamine (DA)? - CORRECT ANSWER -excessive DA release in the NA and
reduced DA release in the PFC
the neurodevelopmental hypothesis of schizophrenia centers heavily around the idea that
aberrant competitive elimination occurs. Competitive elimination is a stage of
