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ADHD is noted for a trio of symptoms what are they?
inattention, hyperactivity, and impulsivity
The prominent symptom of ADHD can also be described as what?
executive dysfunction
Executive dysfunction is hypothetically linked to ineffective information
processing where?
dorsolateral prefrontal cortex
The symptoms of ADHD may occur because patients do not activate what is in
response to cognitive tasks and problem-solving?
prefrontal cortical areas
The firing of NE neurons innervating the prefrontal cortex low in what?
ADHD
What hypothetically contributes to the cognitive dysfunction in ADHD?
Low NE tone
Low NE tone hypothetically contributes to the cognitive dysfunction in ADHD and
preferentially stimulates what?
the most sensitive noradrenergic receptors on postsynaptic neurons
If the firing of DA neurons innervating the prefrontal cortex is also too low in
ADHD there would hypothetically be inadequately what?
tonic DA stimulation
Low release of DA preferentially stimulates the most sensitive DA receptors on
what?
post synaptic neurons but inadequately stimulates D1
, Phasic DA release is thought to reinforce learning and reward conditioning,
providing the motivation to pursue what?
naturally rewarding experiences
Postsynaptic D1 receptors predominate in the prefrontal cortex and the best
functional outcome is when they are tunes and what?
neither under-stimulated nor overstimulated
Alpha 2A and D1 receptors in the prefrontal cortex are often located on the spines
of cortical neurons and can thus do what?
gate incoming signals
The cAMP molecule links the receptors to what?
hyperpolarization-activated cyclic nucleotide-gated cation channels
When NE or a noradrenergic agonist, binds to an alpha 2a receptor, the activated
Gi-linked inhibits cAMP thereby closing what?
HCN channel
The prefrontal cortex stimulation of alpha 2a receptors strengthens what?
an incoming signal
Excessive stimulation of D1 receptors will in contrast to stimulation of alpha 2a
receptors results in what?
the dissipation and or weakness of a signal
Depending if DA or NE is low or high a person will exhibit what?
different symptoms
Most psychiatric disorders have onset in childhood and young adult years and then
does what?
persists into adulthood
Brain development is directed by both genetic and what?
environmental influences