Exam Study Guide 2026/2027
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Describe the difference between mechanoreceptors and nociceptors (size, speed,
and layer of decussation).
Mechanoreceptors = large, fast, decussate at medulla
Nociceptors = small, slow, decussate at spinal cord
Describe the difference between first and second order mechanoreceptors
(function, location, and destination)
First order = detects sensory changes, pseudounipolar, soma located in dorsal root
ganglion, axons go to Pacinian corpuscle and up the spinal cord, until they decussate in
the medulla and synapse with second order
Second order = synapse with first order in medulla and transmit info to the thalamus
Describe the function of form of the Pacinian coropuscle
detects pressure and vibration signals in the skin that produces a graded electrical
potential. Contains stretch-activated Na+ channels
What are receptor potentials?
graded potentials produced by the Pacinian corpuscle, with stronger signals resulting in
stronger depolarizations (also known as generator potentials)
Describe the difference between first, second, and third order nociceptors
First order = directly enters spinal cord and immediately synapses with second order
neurons
Second order = synapses with first order neurons in dorsal root ganglion then
immediately decussates and ascends to posterior lateral nucleus of the thalamus,
where it synapses with third order neurons