Guide 2026/2027
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What is the purpose of regulating glucose?
maintaining stable blood sugar levels via hormones to provide energy to cells
What can happen if there is a deregulation in glucose?
it can lead to severe metabolic complications such as diabetes
Characteristics of Type 1 diabetes
body is unable to produce insulin
characteristics of type 2 diabetes
body is resistant to insulin
What is the major metabolic hormone we learned about?
Insulin
What organ produces insulin in the body?
pancreas
Two receptors that insulin binds to?
IRS-1 and IRS-1
deletion of the insulin receptors leads to what in mice?
increased food intake
Insulin acts as an _____ signal
anorexigenic
Studies in humans have shown that insulin levels fluctuate based on ____
energy consumed
What is the initial trigger for Glucose-Stimulated Insulin Secretion (GSIS) within
the beta cell?
the metabolism of glucose
How does glucose metabolism affect the energy state of the cell?
it leads to an increase in the ATP/ADP ratio
Which specific channel closes in response to an increased ATP/ADP ratio?
The KATP channels
, What does insulin allow the glucose to do to the adipose tissue?
It allows it to enter
Where is GLP- 1 released from?
from endocrine cells in the intestines
How does GLP-1 work?
by binding to the GLP-1 receptor, which is found in the gastrointestinal tract and brain
In obese male participants, GLP-1 administration led to significant _______ in
food intake and appetite
reduction
What is one of the ways GLP-1 can diminish food intake?
by delaying gastric emptying
Where is GLP-1 synthesized?
in the nucleus of the solitary tract
What does GLP-1 mediate?
glucose-stimulated insulin secretion
what does the insular cortex do?
detect the possibility of a bad outcome with food
Leptin is what kiund of signal?
an anorexigenic signal (decreases)
Where is leptin synthesized?
in adipose tissue/body fat in the stomach
What are the two types of adipose tissue?
Brown and white
What does white adipose tissue do?
has interactions with insulin, energy storage and hormone production
Obese individuals show significantly_____levels of circulating leptin
higher
What is homeostasis?
Maintaining a stable internal environment
What is energy regulation?
our capacity to ingest foods when we are hungry
Where are the circuits that effect energy regulation?
The hypothalamus
Who created the idea of homeostatic control?
Claude BErnard
What kind of feedback does homeostasis use?
negative feedback to return to a set point
The ________ has long been implicated in the regulation of ingestive behavior
ventromedial hypothalamus
What would happen if the VMH was to be damaged?
obesity syndrome would occur in humans
what did lesions in the VMH lead to?
profound weight gain due to significant increase in food intake
the lateral hypothalamus is critical to what kind of behavior?
lateral hypothalamus
The LHA receives strong input from