EXAMS COMPLETE ANSWERS AND
PRACTICE SOLUTION
●● Second Line Treatments for alcohol use disorder (according to study
guide but not dynamed)
Answer: Disulfuram and Bupropion (not FDA approved for ETOH but
second line according to study guide)
●● Second Line Treatment for alcohol use disorder (according to
Dynamed)
Answer: Disulfuram
●● Other off label medications for alcohol use disorder according to
Dynamed
Answer: Topiramate, gabapentin, baclofen
●● Other off label medications for alcohol use disorder according to
Stahl's
Answer: Topiramate, ondansetron
●● MOA of Naltrexone
Answer: Opioid Receptor Antagonist
, ●● MOA of Acamprosate
Answer: - weak GABAa agonist
- weak NMDA antagonist
(does not prevent withdrawal symptoms)
●● MOA of Disulfuram
Answer: inhibits enzyme (aldehyde dehydrogenase) in the liver
●● Bupropions role in alcohol use disorder
Answer: Can diminish cravings for etoh, treat underlying
anxiety/depression
●● Safety Risk associated with bupropion and etoh
Answer: bupropion increases the risk of seizures in those going through
etoh withdrawal
●● s/s ETOH intoxication
Answer: impaired fine motor control, impaired judgement and
coordination, ataxic gait, poor balance, lethargy, difficulty sitting
upright, difficulty with memory and sitting upright, N/V, coma in levels
300mg/dL and over with respiratory depression and death possible