2026 EVIDENCE BASED PRACTICE AND
CLINICAL GUIDELINES
◉ Bisphosphonates treat or prevent osteoporosis by:
1. Inhibiting osteoclastic activity
2. Fostering bone resorption
3. Enhancing calcium uptake in the bone
4. Strengthening the osteoclastic proton pump.
Answer: 1. Inhibiting osteoclastic activity
◉ Prophylactic use of bisphosphonates is recommended for patients
with early osteopenia related to long-term use of which of the
following drugs?
1. Selective estrogen receptor modulators
2. Aspirin
,3. Glucocorticoids
4. Calcium supplements.
Answer: 3. Glucocorticoids
◉ Patients with cystic fibrosis are often prescribed enzyme
replacement for pancreatic secretions. Each replacement drug has
lipase, protease, and amylase components, but the drug is
prescribed in units of:
1. Lipase
2. Protease
3. Amylase
4. Pancreatin.
Answer: 1. Lipase
◉ Brands of pancreatic enzyme replacement drugs are:
,1. Bioequivalent
2. About the same in cost per unit of lipase across brands
3. Able to be interchanged between generic and brand-name
products to reduce cost
4. None of the above.
Answer: 2. About the same in cost per unit of lipase across brands
◉ When given subcutaneously, how long until neutral protamine
Hagedorn insulin begins to take effect (onset of action) after
administration?
1. 15 to 30 minutes
2. 60 to 90 minutes
3. 3 to 4 hours
4. 6 to 8 hours.
Answer: 2. 60 to 90 minutes
, ◉ Hypoglycemia can result from the action of either insulin or an
oral hypoglycemic. Signs and symptoms of hypoglycemia include:
1. "Fruity" breath odor and rapid respiration
2. Diarrhea, abdominal pain, weight loss, and hypertension
3. Dizziness, confusion, diaphoresis, and tachycardia
4. Easy bruising, palpitations, cardiac dysrhythmias, and coma.
Answer: 3. Dizziness, confusion, diaphoresis, and tachycardia
◉ Nonselective beta blockers and alcohol create serious drug
interactions with insulin because they:
1. Increase blood glucose levels
2. Produce unexplained diaphoresis
3. Interfere with the ability of the body to metabolize glucose