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Primary brain injury - ANSWER ✔✔occurs as a direct result of the
initial insult, immediately at the onset of brain injury
Secondary brain injury - ANSWER ✔✔progressive damage resulting
from the body's physiologic response to the initial insult, occurs hours to
days after the initial trauma
Most common cause of secondary brain injury - ANSWER
✔✔Ischemia
, Critical factor in determining neural cell fate after injury - ANSWER
✔✔Degree of ATP Depletion
Common secondary injury - ANSWER ✔✔Cerebral edema
Secondary injury that occurs after re-establishing blood flow -
ANSWER ✔✔Reperfusion injury
Hypoxemia - ANSWER ✔✔Decreased oxygen in the blood
Ischemia - ANSWER ✔✔Decreased blood flow
_________ + __________ usually occur together - ANSWER
✔✔ISCHEMIA + HYPOXIA usually occur together
Hypoxia - ANSWER ✔✔Decreased oxygen at the cellular level
Why is the brain so sensitive to oxygen depletion? - ANSWER
✔✔Because of high ATP requirements and limited capacity for anaerobic
metabolism
How long can brain tolerate ATP loss? - ANSWER ✔✔Several
minutes (only takes ~5-10 for permanent damage)
Blood flow through brain is controlled by __________ - ANSWER
✔✔Blood flow through brain is controlled by AUTOREGULATION