Chamberlain University
NR 546 / NR546
Week 4
Anxiolytic Table
Course: Advanced Pharmacology
, Anxiolytic Medications
Drug Name/ Indication Associated Half-life (T1/2) Notable side effects
Medication list diagnosis and targeted Neurotransmitters Metabolism (CYP
class symptoms 450 enzyme)
Gabapentin • Partial seizures • Binds to the Half-Life • Sedation, dizziness
• Postherpetic neuralgia alpha 2 delta • 5-7 • Ataxia, fatigue, nystagmus, tremor
• Restless leg syndrome subunit of hrs. • Peripheral edema
• Neuropathic pain/ voltage-sensitive Metabolism • Blurred vision
chronic pain calcium channels • Does not • Vomiting, dyspepsia, diarrhea, dry
• Anxiety metabolize but mouth, constipation, weight gain
• Bipolar disorder excreted intact • Additional effects in children under 12:
renally hostility, emotional lability,
hyperkinesia,
thought disorder, weight gain
Pregabalin • Diabetic • Binds to the Half-Life • Sedation, dizziness
peripheral alpha 2 delta • 5-7 hours • Ataxia, fatigue, tremor, dysarthria,
neuropathy subunit of Metabolism paresthesia, memory impairment,
• Postherpetic neuralgia voltage-sensitive • Pregabalin is coordination abnormal, impaired
• Fibromyalgia calcium channels not metabolized attention, confusion, euphoric
• Neuropathic pain but excreted mood, irritability
associated with intact renally • Vomiting, dry mouth,
spinal cord injury constipation, weight gain,
• Partial onset seizures increased appetite, flatulence
in adults and • Blurred vision, diplopia
pediatric patients • Peripheral Edema
• Peripheral • Libido decreased, erectile dysfunction
neuropathic
pain
• GAD
• Panic disorder
• Social anxiety disorder
Downloaded by Benjamin Luca ()
NR 546 / NR546
Week 4
Anxiolytic Table
Course: Advanced Pharmacology
, Anxiolytic Medications
Drug Name/ Indication Associated Half-life (T1/2) Notable side effects
Medication list diagnosis and targeted Neurotransmitters Metabolism (CYP
class symptoms 450 enzyme)
Gabapentin • Partial seizures • Binds to the Half-Life • Sedation, dizziness
• Postherpetic neuralgia alpha 2 delta • 5-7 • Ataxia, fatigue, nystagmus, tremor
• Restless leg syndrome subunit of hrs. • Peripheral edema
• Neuropathic pain/ voltage-sensitive Metabolism • Blurred vision
chronic pain calcium channels • Does not • Vomiting, dyspepsia, diarrhea, dry
• Anxiety metabolize but mouth, constipation, weight gain
• Bipolar disorder excreted intact • Additional effects in children under 12:
renally hostility, emotional lability,
hyperkinesia,
thought disorder, weight gain
Pregabalin • Diabetic • Binds to the Half-Life • Sedation, dizziness
peripheral alpha 2 delta • 5-7 hours • Ataxia, fatigue, tremor, dysarthria,
neuropathy subunit of Metabolism paresthesia, memory impairment,
• Postherpetic neuralgia voltage-sensitive • Pregabalin is coordination abnormal, impaired
• Fibromyalgia calcium channels not metabolized attention, confusion, euphoric
• Neuropathic pain but excreted mood, irritability
associated with intact renally • Vomiting, dry mouth,
spinal cord injury constipation, weight gain,
• Partial onset seizures increased appetite, flatulence
in adults and • Blurred vision, diplopia
pediatric patients • Peripheral Edema
• Peripheral • Libido decreased, erectile dysfunction
neuropathic
pain
• GAD
• Panic disorder
• Social anxiety disorder
Downloaded by Benjamin Luca ()
