Chamberlain University
NR 546 / NR546
Week 5
Antidepressant Medications Table
Course: Advanced Pharmacology
, Antidepressant Medications
Indication, Half-life Notes/Notable side effects/Precautions
Name starting dose, (T1/2)
target symptoms, CYP450
and enzyme
affected neurotransmitters
SSRIs
Citalopram • Targe • Weak • Rare seizures, induction of mania, activation
(Celexa) t symptoms inhibito of suicidal ideation Sexual dysfunction
• Depressed mood r of • Decreased appetite, n/d, constipation, dry mouth
• Anxiety CYP450 • Dose dependent insomnia,
• Panic attacks, 2D6 sedation, agitation, tremors,
avoidant Metabolized by headache,dizzy
behavior, CYPf450 3A4 and • Pt with bipolar or psychotic d/o may
reexperiencing 2C19 be more vulnerable to CNS-activating
, hyperarousal actions of SSRIs
• Sleep Half- • Sweating
disturbance, • Bruising and rare bleeding
life 23-
insomnia • Rare hyponatremia
45
and • Syndrome of inappropriate
hour
hypersomnia Indication antidiuretic hormone
CYP450
• Depression
•
• PMDD
• OCD
• Panic d/o
• GAD
• PTSD
• Social
anxiety d/o
Neurotransmitter
• Serotoni
n
Downloaded by Benjamin Luca ()
, Escitalopram Target symptoms Half-life • Sexual dysfunction ED, delayed
(Lexapro) • Depressed mood 27-32 ejaculation, decreased sexual desire,
• Anxiety
hours anorgasmia
• Panic attacks,
CYP450 • Decreased appetite, n/d, constipation, dry mouth
Substrate for • Insomnia and sedation, agitation, tremors,
avoidant CYP450 and 3A4 headache, dizzy
behavior, No significant • Pt with bipolar or psychotic d/o may
reexperiencing, actions on CYP450 be more vulnerable to CNS-activating
hyperarousal enzymes actions of SSRIs
• Sleep • Sweating
disturbance, • Rare hyponatremia
insomnia Syndrome of inappropriate antidiuretic hormone
and secretion
• Rare seizures, induction of mania, activation
hypersomnia
of suicidal ideation
Indication
• MDD 12+
• GAD
• Panic d/o
• OCD
• PTSD
• Social anxiety d/o
• PMDD
Neurotransmitte
r
• Serotonin
Downloaded by Benjamin Luca ()
NR 546 / NR546
Week 5
Antidepressant Medications Table
Course: Advanced Pharmacology
, Antidepressant Medications
Indication, Half-life Notes/Notable side effects/Precautions
Name starting dose, (T1/2)
target symptoms, CYP450
and enzyme
affected neurotransmitters
SSRIs
Citalopram • Targe • Weak • Rare seizures, induction of mania, activation
(Celexa) t symptoms inhibito of suicidal ideation Sexual dysfunction
• Depressed mood r of • Decreased appetite, n/d, constipation, dry mouth
• Anxiety CYP450 • Dose dependent insomnia,
• Panic attacks, 2D6 sedation, agitation, tremors,
avoidant Metabolized by headache,dizzy
behavior, CYPf450 3A4 and • Pt with bipolar or psychotic d/o may
reexperiencing 2C19 be more vulnerable to CNS-activating
, hyperarousal actions of SSRIs
• Sleep Half- • Sweating
disturbance, • Bruising and rare bleeding
life 23-
insomnia • Rare hyponatremia
45
and • Syndrome of inappropriate
hour
hypersomnia Indication antidiuretic hormone
CYP450
• Depression
•
• PMDD
• OCD
• Panic d/o
• GAD
• PTSD
• Social
anxiety d/o
Neurotransmitter
• Serotoni
n
Downloaded by Benjamin Luca ()
, Escitalopram Target symptoms Half-life • Sexual dysfunction ED, delayed
(Lexapro) • Depressed mood 27-32 ejaculation, decreased sexual desire,
• Anxiety
hours anorgasmia
• Panic attacks,
CYP450 • Decreased appetite, n/d, constipation, dry mouth
Substrate for • Insomnia and sedation, agitation, tremors,
avoidant CYP450 and 3A4 headache, dizzy
behavior, No significant • Pt with bipolar or psychotic d/o may
reexperiencing, actions on CYP450 be more vulnerable to CNS-activating
hyperarousal enzymes actions of SSRIs
• Sleep • Sweating
disturbance, • Rare hyponatremia
insomnia Syndrome of inappropriate antidiuretic hormone
and secretion
• Rare seizures, induction of mania, activation
hypersomnia
of suicidal ideation
Indication
• MDD 12+
• GAD
• Panic d/o
• OCD
• PTSD
• Social anxiety d/o
• PMDD
Neurotransmitte
r
• Serotonin
Downloaded by Benjamin Luca ()
