Janeway's Immunobiology (10th Edition) – Questions with Answers &
Rationales
The questions follow the textbook's logical progression, starting with foundational
concepts and moving through innate immunity, adaptive immunity, effector
mechanisms, and clinical applications .
PART 1: BASIC PRINCIPLES OF IMMUNOLOGY (Questions 1-20)
1. The study of the body's specific defense against infection is called:
A) Hematology
B) Immunology
C) Pathology
D) Serology
Answer: B
Rationale: Immunology is the study of the immune system, including both innate
(non-specific) and adaptive (specific) defense mechanisms against pathogens .
2. Who developed the first vaccine against smallpox using cowpox material?
,A) Louis Pasteur
B) Robert Koch
C) Edward Jenner
D) Emil von Behring
Answer: C
Rationale: Edward Jenner developed the smallpox vaccine in 1796 by inoculating
healthy individuals with weakened or attenuated strains of disease-causing agents
to provide protection from disease. This process is called vaccination .
3. The practice of variolation involved:
A) Injecting antibiotics
B) Inhaling or transferring material from smallpox pustules into superficial skin
wounds
C) Administering antiserum
D) Blood transfusions
Answer: B
,Rationale: Variolation was an early form of immunization practiced before
Jenner's vaccine, where material from smallpox pustules was introduced into
healthy individuals to induce mild disease and subsequent immunity .
4. Which scientist discovered phagocytic cells that engulf bacteria, providing
evidence for cellular immunity?
A) Paul Ehrlich
B) Elie Metchnikoff
C) Jules Bordet
D) Robert Koch
Answer: B
Rationale: Elie Metchnikoff discovered bacteria-engulfing phagocytic cells in
blood, which provided crucial evidence for cellular immunity. He shared the 1908
Nobel Prize with Paul Ehrlich .
5. Antibodies are defined as:
A) Cells that destroy pathogens
B) Proteins which bind specifically to toxins and neutralize their activity
, C) Components of the complement system
D) Receptors on T cells
Answer: B
Rationale: Antibodies are specialized proteins that bind specifically to antigens
such as toxins and help destroy infectious agents. They are produced by B cells
and plasma cells .
6. Complement is best described as:
A) A type of antibody
B) A component of serum that acts with antibodies to destroy pathogenic bacteria
C) A T cell receptor
D) An antimicrobial peptide
Answer: B
Rationale: Complement is a group of approximately 30 plasma proteins that act in
conjunction with antibodies to lyse bacteria. Complement can also act
independently of antibodies as part of innate immunity .
Rationales
The questions follow the textbook's logical progression, starting with foundational
concepts and moving through innate immunity, adaptive immunity, effector
mechanisms, and clinical applications .
PART 1: BASIC PRINCIPLES OF IMMUNOLOGY (Questions 1-20)
1. The study of the body's specific defense against infection is called:
A) Hematology
B) Immunology
C) Pathology
D) Serology
Answer: B
Rationale: Immunology is the study of the immune system, including both innate
(non-specific) and adaptive (specific) defense mechanisms against pathogens .
2. Who developed the first vaccine against smallpox using cowpox material?
,A) Louis Pasteur
B) Robert Koch
C) Edward Jenner
D) Emil von Behring
Answer: C
Rationale: Edward Jenner developed the smallpox vaccine in 1796 by inoculating
healthy individuals with weakened or attenuated strains of disease-causing agents
to provide protection from disease. This process is called vaccination .
3. The practice of variolation involved:
A) Injecting antibiotics
B) Inhaling or transferring material from smallpox pustules into superficial skin
wounds
C) Administering antiserum
D) Blood transfusions
Answer: B
,Rationale: Variolation was an early form of immunization practiced before
Jenner's vaccine, where material from smallpox pustules was introduced into
healthy individuals to induce mild disease and subsequent immunity .
4. Which scientist discovered phagocytic cells that engulf bacteria, providing
evidence for cellular immunity?
A) Paul Ehrlich
B) Elie Metchnikoff
C) Jules Bordet
D) Robert Koch
Answer: B
Rationale: Elie Metchnikoff discovered bacteria-engulfing phagocytic cells in
blood, which provided crucial evidence for cellular immunity. He shared the 1908
Nobel Prize with Paul Ehrlich .
5. Antibodies are defined as:
A) Cells that destroy pathogens
B) Proteins which bind specifically to toxins and neutralize their activity
, C) Components of the complement system
D) Receptors on T cells
Answer: B
Rationale: Antibodies are specialized proteins that bind specifically to antigens
such as toxins and help destroy infectious agents. They are produced by B cells
and plasma cells .
6. Complement is best described as:
A) A type of antibody
B) A component of serum that acts with antibodies to destroy pathogenic bacteria
C) A T cell receptor
D) An antimicrobial peptide
Answer: B
Rationale: Complement is a group of approximately 30 plasma proteins that act in
conjunction with antibodies to lyse bacteria. Complement can also act
independently of antibodies as part of innate immunity .
