Mizzou Microbiology Exam 3-
Questions and All Correct Answers.
Where do B-Cells go through positive and negative selection? - Answer bone marrow
The "CATCH-22" of producing and training a CTL requires you to have what organ? - Answer
thymus
While technically possible to start in multiple ways, what process works best if it goes through a
standard "cascade" of proteins first? - Answer complement pathway
What reacts faster and more efficiently after previous experience? - Answer memory cells
What immunological response will always react the same way to any antigen? - Answer
innate immune response
Need macrophages? Need DC's? Get those innate cells functionally activated by yelling this. -
Answer IFN-gamma
What cytokine is responsible for fever? - Answer IL-1
You recognize that it's time to make a change... what cytokine is needed? - Answer IL-4
What cytokine is responsible for T-cell proliferation? - Answer IL-2
What cytokine is part of the general host anti-inflammatory system? - Answer IL-10
What antibody is found only on cell surfaces as a receptor? - Answer IgD
What immunoglobulin is secreted by a naive plasma cell? - Answer IgM
What antibody is an anti-parasitic? - Answer IgE
What antibody is transversing the placenta, being the primary cause of erythroblastosis fetalis
(hemolytic disease of the newborn)? - Answer IgG
, Want to make a better oral vaccine? You can build it better by making surest elicits this potent
antibody response. - Answer IgA mucosal response
What helper cell can give a stalled macrophage that is unresponsive to a phagocytosed Ag one
last chance? - Answer CD4+ Th1 help
Plasma cells can be persuaded to be more effective if Th2 effector cells are present to cause
what? - Answer isotope switching
Cytokines aren't enough for T-cells. They like to help "personally" with what dedicated contact
system for communication? - Answer CD40 CD40L
What cells aren't as good as innate or adaptive (since they have components of both systems),
but help to "fill time" between innate and adaptive immune responses? - Answer NK cells
This "help" for innate function involves coating an Ag with antibodies or complement C3B? -
Answer opsonization
B-cells gain full effective activation from signals such as what? - Answer CD20 and BAFF
Innate cells like macrophages, neutrophils, and DC's are activated by what type of receptor? -
Answer PRR
What completes CD8+CTL activation sequences? - Answer TCR+Ag+MHC-I costimulation
Activation of a neutrophil or basophil or mast cell results in what kind of effector function? -
Answer granule release
What "opposing" cell type is likely part of helping response shut down? - Answer CD4+ Treg
cell
What cell types are pro-inflammation? - Answer CD4+ Th17
This problem, while essentially a "targeting" issue, is surprisingly necessary in the body for
maintaining the health of the system? - Answer autoimmune reaction
A defect in RAG recombinase leads to a total lack of lymphocytes, known as what condition? -
Answer SCID
Questions and All Correct Answers.
Where do B-Cells go through positive and negative selection? - Answer bone marrow
The "CATCH-22" of producing and training a CTL requires you to have what organ? - Answer
thymus
While technically possible to start in multiple ways, what process works best if it goes through a
standard "cascade" of proteins first? - Answer complement pathway
What reacts faster and more efficiently after previous experience? - Answer memory cells
What immunological response will always react the same way to any antigen? - Answer
innate immune response
Need macrophages? Need DC's? Get those innate cells functionally activated by yelling this. -
Answer IFN-gamma
What cytokine is responsible for fever? - Answer IL-1
You recognize that it's time to make a change... what cytokine is needed? - Answer IL-4
What cytokine is responsible for T-cell proliferation? - Answer IL-2
What cytokine is part of the general host anti-inflammatory system? - Answer IL-10
What antibody is found only on cell surfaces as a receptor? - Answer IgD
What immunoglobulin is secreted by a naive plasma cell? - Answer IgM
What antibody is an anti-parasitic? - Answer IgE
What antibody is transversing the placenta, being the primary cause of erythroblastosis fetalis
(hemolytic disease of the newborn)? - Answer IgG
, Want to make a better oral vaccine? You can build it better by making surest elicits this potent
antibody response. - Answer IgA mucosal response
What helper cell can give a stalled macrophage that is unresponsive to a phagocytosed Ag one
last chance? - Answer CD4+ Th1 help
Plasma cells can be persuaded to be more effective if Th2 effector cells are present to cause
what? - Answer isotope switching
Cytokines aren't enough for T-cells. They like to help "personally" with what dedicated contact
system for communication? - Answer CD40 CD40L
What cells aren't as good as innate or adaptive (since they have components of both systems),
but help to "fill time" between innate and adaptive immune responses? - Answer NK cells
This "help" for innate function involves coating an Ag with antibodies or complement C3B? -
Answer opsonization
B-cells gain full effective activation from signals such as what? - Answer CD20 and BAFF
Innate cells like macrophages, neutrophils, and DC's are activated by what type of receptor? -
Answer PRR
What completes CD8+CTL activation sequences? - Answer TCR+Ag+MHC-I costimulation
Activation of a neutrophil or basophil or mast cell results in what kind of effector function? -
Answer granule release
What "opposing" cell type is likely part of helping response shut down? - Answer CD4+ Treg
cell
What cell types are pro-inflammation? - Answer CD4+ Th17
This problem, while essentially a "targeting" issue, is surprisingly necessary in the body for
maintaining the health of the system? - Answer autoimmune reaction
A defect in RAG recombinase leads to a total lack of lymphocytes, known as what condition? -
Answer SCID
