March 2026 Complete Actual Exam
Questions 1- 100 NR-507 Advanced
Pathophysiology NR 507 Midterm and
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Question 1: Which process results in the movement of water between the ICF and
ECF compartments?
A. Active transport
B. Facilitated diffusion
C. Osmosis
D. Endocytosis
Correct ,,answer,,,,: C. Osmosis
Rationale: Osmosis is the movement of water across a semipermeable membrane
from an area of low solute concentration to an area of high solute concentration to
maintain equilibrium. This is the primary mechanism for water distribution
between intracellular and extracellular fluid compartments .
,Question 2: A patient has a pH of 7.22 and a PaCO2 of 60. This is characteristic
of:
A. Metabolic Acidosis
B. Respiratory Acidosis
C. Metabolic Alkalosis
D. Respiratory Alkalosis
Correct ,,answer,,,,: B. Respiratory Acidosis
Rationale: A pH below 7.35 indicates acidosis. A PaCO2 above 45 mmHg
indicates the cause is respiratory (hypoventilation), as CO2 is an acid. In
respiratory acidosis, the PaCO2 is elevated, and the pH is decreased .
Question 3: Which type of cell adaptation occurs when the lining of the esophagus
changes from squamous to columnar cells due to chronic acid reflux?
A. Atrophy
B. Hyperplasia
C. Metaplasia
D. Dysplasia
Correct ,,answer,,,,: C. Metaplasia
Rationale: Metaplasia is the reversible replacement of one mature cell type by
another, often as a protective response to chronic irritation. In Barrett's esophagus,
chronic acid reflux causes the normal squamous epithelium to transform into
columnar epithelium as an adaptive response .
,Question 4: What is the primary cause of symptoms in Pernicious Anemia?
A. Iron deficiency
B. Chronic blood loss
C. Lack of Intrinsic Factor
D. Folic acid deficiency
Correct ,,answer,,,,: C. Lack of Intrinsic Factor
Rationale: Intrinsic factor is required for Vitamin B12 absorption in the ileum.
Without it, Vitamin B12 cannot be absorbed, leading to megaloblastic anemia and
neurological symptoms. This is an autoimmune destruction of parietal cells in the
stomach .
Question 5: Which electrolyte imbalance is a common cause of flattened T-waves
and the presence of U-waves on an EKG?
A. Hyperkalemia
B. Hypokalemia
C. Hypercalcemia
D. Hyponatremia
Correct ,,answer,,,,: B. Hypokalemia
Rationale: Low potassium levels delay ventricular repolarization, leading to
flattened T-waves and prominent U-waves on EKG. Hyperkalemia classically
shows peaked T-waves .
, Question 6: In the inflammatory response, which cells are the "first responders"
that arrive at the site of injury?
A. Macrophages
B. Neutrophils
C. Lymphocytes
D. Eosinophils
Correct ,,answer,,,,: B. Neutrophils
Rationale: Neutrophils are the first leukocytes to arrive at the site of inflammation
(within 6-12 hours). They phagocytose bacteria and release inflammatory
mediators. Macrophages arrive later and are involved in chronic inflammation .
Question 7: Allergic contact dermatitis is an example of which type of
hypersensitivity reaction?
A. Type I
B. Type II
C. Type III
D. Type IV
Correct ,,answer,,,,: D. Type IV
Rationale: Type IV hypersensitivity is a delayed-type hypersensitivity mediated
by T-lymphocytes rather than antibodies. Allergic contact dermatitis (e.g., poison
ivy) occurs 24-72 hours after exposure and is mediated by memory T-cells .