2025 Complete Actual Exam Questions 1- 100
NR-511 Differential Diagnosis & Primary Care
Practicum NR 511 Midterm and Finals Examplify
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Part 1: Gastrointestinal Disorders (Questions 1-20)
1. A 27-year-old woman presents with bloating and abdominal pain relieved by
defecation. Her tests show normal CBC, CMP, ESR, and CRP. Which diagnosis
is MOST important to rule out before confirming IBS?
A) Appendicitis
B) Celiac disease
C) Crohn's disease
D) Peptic ulcer disease
Rationale: Celiac disease mimics IBS and must be ruled out with serology (tissue
transglutaminase IgA) before diagnosing IBS.
2. A 29-year-old woman presents with 6 months of crampy abdominal pain
relieved by defefecation, intermittent diarrhea, and bloating. She denies weight
loss, fever, or rectal bleeding. What is the MOST appropriate next step?
A) Immediately schedule colonoscopy with random biopsies
B) Order stool studies including fecal fat, weight, laxative screen, and tests for
,microorganisms
C) Begin empiric treatment for ulcerative colitis without further testing
D) Refer urgently for abdominal CT with contrast
Rationale: In IBS-like presentations with diarrhea as the dominant symptom, stool
studies for fecal fat, microorganisms, and celiac serology should be ordered to
exclude organic causes before confirming IBS.
3. A patient has persistent heartburn despite lifestyle changes. What is the
most appropriate FIRST-LINE medication?
A) Antacids
B) H2 blocker
C) Proton pump inhibitor
D) Sucralfate
Rationale: PPIs are the most effective therapy for healing esophagitis and providing
symptom relief in patients with GERD who fail to respond to lifestyle modifications
or H2 blockers.
4. A 48-year-old man reports burning chest pain after large meals that worsens
when lying down and improves with antacids. He denies dysphagia, weight
loss, or GI bleeding. Which is the MOST likely diagnosis?
A) Acute cholecystitis
B) Gastroesophageal reflux disease (GERD)
C) Peptic ulcer disease
D) Acute pancreatitis
Rationale: The classic presentation of GERD is heartburn (pyrosis) ranging from
mild to severe, often associated with meals and positional changes, and relieved by
antacids.
,5. A 43-year-old woman has episodic epigastric pain that radiates to the back,
occurs after fatty meals, and is associated with nausea. Murphy's sign is
positive. Which diagnostic test is MOST appropriate first?
A) Abdominal ultrasound
B) CT abdomen with contrast
C) Colonoscopy
D) Upper GI series with barium
Rationale: RUQ ultrasound is the initial imaging test for suspected biliary disease
such as cholelithiasis or acute cholecystitis, where postprandial pain and a positive
Murphy's sign are typical.
6. A 21-year-old woman presents with sudden periumbilical pain that migrated
to the right lower quadrant over 24 hours, low-grade fever, and anorexia. RLQ
tenderness with guarding is present. Which is the MOST likely diagnosis?
A) Diverticulitis
B) Crohn's disease flare
C) Appendicitis
D) Irritable bowel syndrome
Rationale: Classic appendicitis manifests as initially vague periumbilical pain that
localizes to the RLQ with tenderness, fever, and anorexia.
7. A 40-year-old man has burning epigastric pain relieved by food and antacids.
He takes NSAIDs daily. You suspect peptic ulcer disease. Which H. pylori test
is BEST for initial noninvasive diagnosis in this outpatient setting?
A) Serum H. pylori IgG antibody
B) Urea breath test
C) Endoscopic biopsy with culture in all patients
D) Stool occult blood testing
, Rationale: Noninvasive tests such as urea breath testing are preferred for detecting
active H. pylori infection, whereas serology may reflect past exposure and is less
useful.
8. Progressive solid-food dysphagia is most characteristic of which condition?
A) GERD
B) Esophageal stricture
C) Peptic ulcer disease
D) Achalasia
Rationale: Progressive solid-food dysphagia is classic for esophageal stricture,
often due to chronic GERD.
9. A 62-year-old woman has chronic watery diarrhea, weight loss, and
abdominal cramping. You are considering IBS but are concerned about organic
disease. Which finding would MOST strongly argue against IBS?
A) Symptoms that improve after defecation
B) Symptoms worsened by stress
C) Nocturnal diarrhea and rectal bleeding
D) Normal abdominal exam
Rationale: Alarm features such as rectal bleeding, weight loss, and nocturnal
symptoms raise concern for IBD or malignancy rather than functional IBS.
10. A 55-year-old man with longstanding GERD reports new-onset dysphagia
for solids. He has been taking OTC antacids only. What is the MOST
appropriate next step?
A) Refer for upper endoscopy (EGD)
B) Start high-dose PPI and re-evaluate in 3 months
C) Order barium swallow only
D) Reassure and recommend lifestyle changes only