September 2025 Complete Questions 1-100
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NR566 Advanced Pharmacology For Care Of
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SECTION 1: HEART FAILURE & CARDIOVASCULAR PHARMACOLOGY
(Qs 1–15)
Question 1: A 58-year-old male with a history of heart failure with reduced ejection
fraction (HFrEF) presents with dyspnea. He is currently on Lisinopril, but his
blood pressure remains elevated. What is the BEST next step in his pharmacologic
management to improve mortality?
A. Add Hydrochlorothiazide
B. Switch Lisinopril to Losartan
C. Add Metoprolol succinate
D. Add Amlodipine
Correct ,,answer,,,,: C. Add Metoprolol succinate
Rationale: Beta-blockers (specifically carvedilol, metoprolol succinate, and
bisoprolol) are cornerstone therapies for HFrEF that improve mortality, along with
ACE inhibitors . Adding a beta-blocker provides mortality benefit beyond ACE
inhibition alone, while amlodipine has no mortality benefit in HFrEF .
,Question 2: Which of the following blood pressure medications is NOT
recommended for heart failure with reduced ejection fraction (HFrEF)?
A. Carvedilol
B. Amlodipine
C. Lisinopril
D. Spironolactone
Correct ,,answer,,,,: B. Amlodipine
Rationale: Guideline-directed medical therapy for HFrEF includes beta-blockers
(carvedilol, metoprolol succinate, bisoprolol), ACE inhibitors/ARBs/ARNI
(lisinopril, sacubitril/valsartan), and mineralocorticoid receptor antagonists
(spironolactone, eplerenone). Amlodipine, a dihydropyridine calcium channel
blocker, provides no mortality benefit in HFrEF and is not part of the core four-
drug regimen .
Question 3: A patient on a beta-blocker for heart failure states, "I will stop the
medication if I feel dizzy." Which statement indicates the patient needs further
teaching?
A. "I will monitor my weight daily."
B. "I will stop the medication if I feel dizzy."
C. "I will report any swelling in my legs."
D. "I will take my pulse before taking the medication."
,Correct ,,answer,,,,: B. "I will stop the medication if I feel dizzy."
Rationale: Beta-blockers should not be stopped abruptly in heart failure patients, as
this can cause rebound tachycardia, worsening heart failure, or myocardial
ischemia (reflex sympathetic activation increases cardiac workload and oxygen
demand). The patient should contact the provider if side effects occur rather than
stopping the medication on their own .
Question 4: Which of the following end-organ sequelae is NOT directly caused by
uncontrolled hypertension?
A. Proteinuria
B. AV nicking
C. Hemorrhagic stroke
D. Peripheral neuropathy
Correct ,,answer,,,,: D. Peripheral neuropathy
Rationale: Although patients with hypertension frequently have peripheral
neuropathy, it is only directly attributed to patients who are also diabetic and is
commonly found in non-hypertensive diabetic patients. Proteinuria, AV nicking,
and hemorrhagic stroke are all directly caused by uncontrolled hypertension .
Question 5: A patient is on a beta-blocker for heart failure. Which statement
indicates the patient needs further teaching?
A. "I will monitor my weight daily."
, B. "I will stop the medication if I feel dizzy."
C. "I will report any swelling in my legs."
D. "I will take my pulse before taking the medication."
Correct ,,answer,,,,: B. "I will stop the medication if I feel dizzy."
Rationale: Beta-blockers should not be stopped abruptly in heart failure patients, as
this can cause rebound tachycardia, worsening heart failure, or myocardial
ischemia. The patient should contact the provider if side effects occur rather than
stopping the medication on their own .
Question 6: Which of the following is a true contraindication to beta-blocker
therapy?
A. Heart failure with reduced ejection fraction
B. Compensated cirrhosis
C. Second or third-degree AV block without a pacemaker
D. Chronic kidney disease stage 3
Correct ,,answer,,,,: C. Second or third-degree AV block without a pacemaker
Rationale: Beta-blockers slow AV conduction and can precipitate complete heart
block in patients with existing second or third-degree AV block who do not have a
functioning pacemaker. They are beneficial in HFrEF and are safe in compensated
cirrhosis, CKD, and many other conditions .