ELITE COMPREHENSIVE
ATI PHARMACOLOGY CONTENT MASTERY
SERIES (CMS) EXAM 2026
COMPREHENSIVE NCLEX-PN/RN PRACTICE
EXAM QUESTIONS COVERING SAFE
MEDICATION ADMINISTRATION
SPRING EXAMINATION MAY 2026
A nurse reviewing a client's medical record notes a new prescription for verifying the
trough level of the client's medication. Which of the following actions should the nurse
take?
A. Obtain a blood specimen immediately prior to administering the next dose of
medication.
B. Verify that the client has been taking the medication for 24 hr before obtaining a
blood specimen.
C. Ask the client to provide a urine specimen after the next dose of medication.
D. Administer the medication,and obtain a blood specimen 30 min late
✓ Obtain a blood specimen immediately prior to administering the
next dose of medication.
1
Page
, A nurse is preparing a client's medications. Which of the following actions should the
nurse take in following legal practice guidelines? (Select all that apply)
A. Teach the client about the med
B. Determine the dosage
C. Monitor for adverse effects
D. Lock compartments for controlled substances
E. Determine the clients insurance status
✓ Teach the client about the med
✓ Monitor for adverse effects
✓ Lock compartments for controlled substances
The nurse is preparing to administer digoxin to a client who states, "I don't want to take
that medication. I do not want one more pill." Which of the following responses should
the nurse make?
A. Your physician prescribes it for you, so you really should take it
B. Well, lets just get it over quickly then
C. Okay, ill just give you your other medications
D. Tell me your concerns about taking this medication
✓ D. Tell me your concerns about taking this medication
The nurse is reviewing a client's prescribed medications. Which of the following
situations represents a contraindication to med administrations?
A. The client drank grapefruit juice, which could reduce a medications effectiveness
B. The medication has orthostatic hypotension as an adverse effect
2
Page
C. A medication is approved for ages 12 and older, and the client is 8 years old
, D. An antianxiety medication has an adverse effect of drowsiness is prescribed as a
preoperative sedative
✓ C. A medication is approved for ages 12 and older, and the client is 8
years old
The nurse is assessing a client before administering medications. Which of the following
data should the nurse obtain? (select all the apply)
A. Use of herbal products
B. Daily fluid intake
C. Ability to swallow
D. Previous surgical history
E. Allergies
✓ Use of herbal products
✓ Ability to swallow
✓ E. Allergies
A nurse is working with a newly hired nurse who is administering medications to clients.
Which of the following actions by the newly hired nurse indicates an understanding of
medication error prevention.
A. Taking all medications out of the unit- dose wrappers before entering the clients room
B. Checking with the provider when a single dose requires administration of multiple
tablets
C. Administering a medication, then looking up the usual dosage range.
D. Relying on another nurse to clarify a medication prescription.
✓ B. Checking with the provider when a single dose requires
administration of multiple tablets
3
Page
, A nurse is caring for a client experiencing IV extravasation. The facility requires the
administration of an antidote for the prescribed IV solution. After stopping the IV
infusion, which of the following actions should the nurse take first?
A. Remove the IV catheter
B. Withdraw the solution from the IV access
C. Administer the antidote to the vesicant
D. Insert a new IV access in a different extremity
✓ B. Withdraw the solution from the IV access
A nurse is preparing to initiate IV therapy for an older adult client. Which of the following
actions should the nurse plan to take?A. Use a disposable razor to remove excess hair
on the extremity
B. Select the back of the client's hand to insert the IV catheter
C. Distend the veins by using a blood pressure cuff
D. Direct the client to raise their arm above their heart
✓ C. Distend the veins by using a blood pressure cuff
A nurse assessing the IV catheter insertion site for a client receiving a non vesicant
solution and notes swelling at the site with decreased skin temperature. Which of the
following actions should the nurse take? (select all that apply)
A. Stop the infusion
B. Start a new IV access distal to this site
C. Apply warm compresses to the insertion site
D. Elevate the client's arm
4
E. Obtain a specimen for culture at the insertion site
Page
✓ Stop the infusion
ATI PHARMACOLOGY CONTENT MASTERY
SERIES (CMS) EXAM 2026
COMPREHENSIVE NCLEX-PN/RN PRACTICE
EXAM QUESTIONS COVERING SAFE
MEDICATION ADMINISTRATION
SPRING EXAMINATION MAY 2026
A nurse reviewing a client's medical record notes a new prescription for verifying the
trough level of the client's medication. Which of the following actions should the nurse
take?
A. Obtain a blood specimen immediately prior to administering the next dose of
medication.
B. Verify that the client has been taking the medication for 24 hr before obtaining a
blood specimen.
C. Ask the client to provide a urine specimen after the next dose of medication.
D. Administer the medication,and obtain a blood specimen 30 min late
✓ Obtain a blood specimen immediately prior to administering the
next dose of medication.
1
Page
, A nurse is preparing a client's medications. Which of the following actions should the
nurse take in following legal practice guidelines? (Select all that apply)
A. Teach the client about the med
B. Determine the dosage
C. Monitor for adverse effects
D. Lock compartments for controlled substances
E. Determine the clients insurance status
✓ Teach the client about the med
✓ Monitor for adverse effects
✓ Lock compartments for controlled substances
The nurse is preparing to administer digoxin to a client who states, "I don't want to take
that medication. I do not want one more pill." Which of the following responses should
the nurse make?
A. Your physician prescribes it for you, so you really should take it
B. Well, lets just get it over quickly then
C. Okay, ill just give you your other medications
D. Tell me your concerns about taking this medication
✓ D. Tell me your concerns about taking this medication
The nurse is reviewing a client's prescribed medications. Which of the following
situations represents a contraindication to med administrations?
A. The client drank grapefruit juice, which could reduce a medications effectiveness
B. The medication has orthostatic hypotension as an adverse effect
2
Page
C. A medication is approved for ages 12 and older, and the client is 8 years old
, D. An antianxiety medication has an adverse effect of drowsiness is prescribed as a
preoperative sedative
✓ C. A medication is approved for ages 12 and older, and the client is 8
years old
The nurse is assessing a client before administering medications. Which of the following
data should the nurse obtain? (select all the apply)
A. Use of herbal products
B. Daily fluid intake
C. Ability to swallow
D. Previous surgical history
E. Allergies
✓ Use of herbal products
✓ Ability to swallow
✓ E. Allergies
A nurse is working with a newly hired nurse who is administering medications to clients.
Which of the following actions by the newly hired nurse indicates an understanding of
medication error prevention.
A. Taking all medications out of the unit- dose wrappers before entering the clients room
B. Checking with the provider when a single dose requires administration of multiple
tablets
C. Administering a medication, then looking up the usual dosage range.
D. Relying on another nurse to clarify a medication prescription.
✓ B. Checking with the provider when a single dose requires
administration of multiple tablets
3
Page
, A nurse is caring for a client experiencing IV extravasation. The facility requires the
administration of an antidote for the prescribed IV solution. After stopping the IV
infusion, which of the following actions should the nurse take first?
A. Remove the IV catheter
B. Withdraw the solution from the IV access
C. Administer the antidote to the vesicant
D. Insert a new IV access in a different extremity
✓ B. Withdraw the solution from the IV access
A nurse is preparing to initiate IV therapy for an older adult client. Which of the following
actions should the nurse plan to take?A. Use a disposable razor to remove excess hair
on the extremity
B. Select the back of the client's hand to insert the IV catheter
C. Distend the veins by using a blood pressure cuff
D. Direct the client to raise their arm above their heart
✓ C. Distend the veins by using a blood pressure cuff
A nurse assessing the IV catheter insertion site for a client receiving a non vesicant
solution and notes swelling at the site with decreased skin temperature. Which of the
following actions should the nurse take? (select all that apply)
A. Stop the infusion
B. Start a new IV access distal to this site
C. Apply warm compresses to the insertion site
D. Elevate the client's arm
4
E. Obtain a specimen for culture at the insertion site
Page
✓ Stop the infusion
