COMSAE Phase 1 Form D Questions With
Correct Answers (Verified Answers) Plus
Rationales 2026 Q&A | Instant Download Pdf
1. A 45-year-old man presents with chest pain radiating to his left
arm. ECG shows ST elevation in leads II, III, and aVF. Which
coronary artery is most likely occluded?
A. Left anterior descending artery
B. Left circumflex artery
C. Right coronary artery
D. Posterior descending artery
C. Right coronary artery
Rationale: ST elevations in II, III, and aVF indicate an inferior wall
myocardial infarction. The right coronary artery most commonly
supplies the inferior wall of the heart, making it the most likely
site of occlusion.
2. A patient has chronic cough and hemoptysis. Imaging reveals a
cavitary lesion in the upper lobe. What is the most likely causative
organism?
A. Streptococcus pneumoniae
, B. Mycobacterium tuberculosis
C. Klebsiella pneumoniae
D. Haemophilus influenzae
B. Mycobacterium tuberculosis
Rationale: Reactivation tuberculosis commonly affects the upper
lobes and produces caseating granulomas and cavitary lesions,
along with symptoms like chronic cough and hemoptysis.
3. Which structure is primarily responsible for filtration in the
kidney?
A. Proximal convoluted tubule
B. Loop of Henle
C. Glomerulus
D. Distal convoluted tubule
C. Glomerulus
Rationale: The glomerulus is the site of plasma filtration in the
nephron, driven by hydrostatic pressure across the glomerular
capillaries.
4. A child presents with a “slapped cheek” rash. Which virus is
responsible?
A. Measles virus
B. Parvovirus B19
, C. Rubella virus
D. Epstein-Barr virus
B. Parvovirus B19
Rationale: Parvovirus B19 causes erythema infectiosum,
characterized by a “slapped cheek” rash in children and can also
cause aplastic crisis in sickle cell disease.
5. Which hormone increases calcium reabsorption in the kidney and
activates vitamin D?
A. Calcitonin
B. Parathyroid hormone
C. Aldosterone
D. Cortisol
B. Parathyroid hormone
Rationale: PTH increases serum calcium by increasing renal
reabsorption, stimulating osteoclast activity, and activating
vitamin D in the kidney.
6. A 60-year-old man with smoking history has painless hematuria.
What is the most likely diagnosis?
A. Renal cell carcinoma
B. Bladder cancer
C. Kidney stones
, D. Urinary tract infection
B. Bladder cancer
Rationale: Painless hematuria in an older smoker is classic for
transitional cell carcinoma of the bladder.
7. Which vitamin deficiency causes night blindness?
A. Vitamin A
B. Vitamin B12
C. Vitamin C
D. Vitamin D
A. Vitamin A
Rationale: Vitamin A is essential for rhodopsin production in the
retina; deficiency leads to impaired dark adaptation and night
blindness.
8. A patient has resting tremor, bradykinesia, and rigidity. Which
structure is primarily affected?
A. Caudate nucleus
B. Substantia nigra
C. Cerebellum
D. Red nucleus
B. Substantia nigra
Correct Answers (Verified Answers) Plus
Rationales 2026 Q&A | Instant Download Pdf
1. A 45-year-old man presents with chest pain radiating to his left
arm. ECG shows ST elevation in leads II, III, and aVF. Which
coronary artery is most likely occluded?
A. Left anterior descending artery
B. Left circumflex artery
C. Right coronary artery
D. Posterior descending artery
C. Right coronary artery
Rationale: ST elevations in II, III, and aVF indicate an inferior wall
myocardial infarction. The right coronary artery most commonly
supplies the inferior wall of the heart, making it the most likely
site of occlusion.
2. A patient has chronic cough and hemoptysis. Imaging reveals a
cavitary lesion in the upper lobe. What is the most likely causative
organism?
A. Streptococcus pneumoniae
, B. Mycobacterium tuberculosis
C. Klebsiella pneumoniae
D. Haemophilus influenzae
B. Mycobacterium tuberculosis
Rationale: Reactivation tuberculosis commonly affects the upper
lobes and produces caseating granulomas and cavitary lesions,
along with symptoms like chronic cough and hemoptysis.
3. Which structure is primarily responsible for filtration in the
kidney?
A. Proximal convoluted tubule
B. Loop of Henle
C. Glomerulus
D. Distal convoluted tubule
C. Glomerulus
Rationale: The glomerulus is the site of plasma filtration in the
nephron, driven by hydrostatic pressure across the glomerular
capillaries.
4. A child presents with a “slapped cheek” rash. Which virus is
responsible?
A. Measles virus
B. Parvovirus B19
, C. Rubella virus
D. Epstein-Barr virus
B. Parvovirus B19
Rationale: Parvovirus B19 causes erythema infectiosum,
characterized by a “slapped cheek” rash in children and can also
cause aplastic crisis in sickle cell disease.
5. Which hormone increases calcium reabsorption in the kidney and
activates vitamin D?
A. Calcitonin
B. Parathyroid hormone
C. Aldosterone
D. Cortisol
B. Parathyroid hormone
Rationale: PTH increases serum calcium by increasing renal
reabsorption, stimulating osteoclast activity, and activating
vitamin D in the kidney.
6. A 60-year-old man with smoking history has painless hematuria.
What is the most likely diagnosis?
A. Renal cell carcinoma
B. Bladder cancer
C. Kidney stones
, D. Urinary tract infection
B. Bladder cancer
Rationale: Painless hematuria in an older smoker is classic for
transitional cell carcinoma of the bladder.
7. Which vitamin deficiency causes night blindness?
A. Vitamin A
B. Vitamin B12
C. Vitamin C
D. Vitamin D
A. Vitamin A
Rationale: Vitamin A is essential for rhodopsin production in the
retina; deficiency leads to impaired dark adaptation and night
blindness.
8. A patient has resting tremor, bradykinesia, and rigidity. Which
structure is primarily affected?
A. Caudate nucleus
B. Substantia nigra
C. Cerebellum
D. Red nucleus
B. Substantia nigra
