COMSAE Phase 1 Form F Questions With
Correct Answers (Verified Answers) Plus
Rationales 2026 Q&A | Instant Download Pdf
1. A 55-year-old man presents with exertional chest pain relieved by
rest. Which of the following is the most likely underlying
mechanism?
A. Coronary artery vasospasm
B. Atherosclerotic plaque with fixed stenosis
C. Aortic dissection
D. Pulmonary embolism
Answer: B. Atherosclerotic plaque with fixed stenosis
Rationale: Stable angina is most commonly caused by fixed
atherosclerotic narrowing of coronary arteries. This limits
oxygen delivery during increased demand (exercise), but at rest
perfusion is adequate. Vasospasm would suggest Prinzmetal
angina, which is typically at rest.
2. Which electrolyte abnormality is most associated with peaked T
waves on ECG?
A. Hypocalcemia
, B. Hyperkalemia
C. Hypokalemia
D. Hypernatremia
Answer: B. Hyperkalemia
Rationale: Hyperkalemia classically causes peaked T waves due
to accelerated ventricular repolarization. As levels worsen, QRS
widening and sine wave patterns may occur.
3. A patient has decreased insulin secretion. Which organ is primarily
affected?
A. Liver
B. Pancreas beta cells
C. Adrenal cortex
D. Thyroid gland
Answer: B. Pancreas beta cells
Rationale: Insulin is produced by beta cells in the islets of
Langerhans in the pancreas. Destruction or dysfunction of these
cells leads to decreased insulin secretion, as seen in type 1
diabetes.
4. Which type of hypersensitivity is mediated by IgE antibodies?
A. Type I
B. Type II
, C. Type III
D. Type IV
Answer: A. Type I
Rationale: Type I hypersensitivity reactions are immediate and
IgE-mediated, involving mast cell degranulation. Examples
include anaphylaxis and allergic rhinitis.
5. A patient with COPD is most likely to have which arterial blood gas
finding?
A. Respiratory alkalosis
B. Metabolic alkalosis
C. Respiratory acidosis
D. Metabolic acidosis
Answer: C. Respiratory acidosis
Rationale: COPD causes hypoventilation and CO₂ retention,
leading to respiratory acidosis. Chronic cases may show renal
compensation with elevated bicarbonate.
6. Which vitamin deficiency is associated with scurvy?
A. Vitamin A
B. Vitamin B1
C. Vitamin C
D. Vitamin D
, Answer: C. Vitamin C
Rationale: Vitamin C is required for collagen synthesis. Deficiency
leads to impaired connective tissue integrity, causing bleeding
gums, bruising, and poor wound healing.
7. Which structure is primarily responsible for filtering blood in the
kidney?
A. Collecting duct
B. Loop of Henle
C. Glomerulus
D. Proximal tubule
Answer: C. Glomerulus
Rationale: The glomerulus performs ultrafiltration of plasma
based on size and charge, forming the initial filtrate in urine
production.
8. Which organism is most commonly associated with peptic ulcer
disease?
A. Escherichia coli
B. Helicobacter pylori
C. Staphylococcus aureus
D. Clostridium difficile
Answer: B. Helicobacter pylori
Correct Answers (Verified Answers) Plus
Rationales 2026 Q&A | Instant Download Pdf
1. A 55-year-old man presents with exertional chest pain relieved by
rest. Which of the following is the most likely underlying
mechanism?
A. Coronary artery vasospasm
B. Atherosclerotic plaque with fixed stenosis
C. Aortic dissection
D. Pulmonary embolism
Answer: B. Atherosclerotic plaque with fixed stenosis
Rationale: Stable angina is most commonly caused by fixed
atherosclerotic narrowing of coronary arteries. This limits
oxygen delivery during increased demand (exercise), but at rest
perfusion is adequate. Vasospasm would suggest Prinzmetal
angina, which is typically at rest.
2. Which electrolyte abnormality is most associated with peaked T
waves on ECG?
A. Hypocalcemia
, B. Hyperkalemia
C. Hypokalemia
D. Hypernatremia
Answer: B. Hyperkalemia
Rationale: Hyperkalemia classically causes peaked T waves due
to accelerated ventricular repolarization. As levels worsen, QRS
widening and sine wave patterns may occur.
3. A patient has decreased insulin secretion. Which organ is primarily
affected?
A. Liver
B. Pancreas beta cells
C. Adrenal cortex
D. Thyroid gland
Answer: B. Pancreas beta cells
Rationale: Insulin is produced by beta cells in the islets of
Langerhans in the pancreas. Destruction or dysfunction of these
cells leads to decreased insulin secretion, as seen in type 1
diabetes.
4. Which type of hypersensitivity is mediated by IgE antibodies?
A. Type I
B. Type II
, C. Type III
D. Type IV
Answer: A. Type I
Rationale: Type I hypersensitivity reactions are immediate and
IgE-mediated, involving mast cell degranulation. Examples
include anaphylaxis and allergic rhinitis.
5. A patient with COPD is most likely to have which arterial blood gas
finding?
A. Respiratory alkalosis
B. Metabolic alkalosis
C. Respiratory acidosis
D. Metabolic acidosis
Answer: C. Respiratory acidosis
Rationale: COPD causes hypoventilation and CO₂ retention,
leading to respiratory acidosis. Chronic cases may show renal
compensation with elevated bicarbonate.
6. Which vitamin deficiency is associated with scurvy?
A. Vitamin A
B. Vitamin B1
C. Vitamin C
D. Vitamin D
, Answer: C. Vitamin C
Rationale: Vitamin C is required for collagen synthesis. Deficiency
leads to impaired connective tissue integrity, causing bleeding
gums, bruising, and poor wound healing.
7. Which structure is primarily responsible for filtering blood in the
kidney?
A. Collecting duct
B. Loop of Henle
C. Glomerulus
D. Proximal tubule
Answer: C. Glomerulus
Rationale: The glomerulus performs ultrafiltration of plasma
based on size and charge, forming the initial filtrate in urine
production.
8. Which organism is most commonly associated with peptic ulcer
disease?
A. Escherichia coli
B. Helicobacter pylori
C. Staphylococcus aureus
D. Clostridium difficile
Answer: B. Helicobacter pylori
