COMSAE Phase 2 Cognitive Evaluation Form A
Questions With Correct Answers (Verified
Answers) Plus Rationales 2026 Q&A | Instant
Download Pdf
1. A 65-year-old man with a history of smoking presents with
progressive dyspnea and chronic cough producing sputum.
Spirometry shows FEV1/FVC of 55%. What is the most likely
diagnosis?
A. Asthma
B. COPD
C. Pulmonary fibrosis
D. Bronchiectasis
Answer: B. COPD
Rationale: COPD is characterized by persistent airflow limitation
with FEV1/FVC < 70%, most commonly due to smoking history
and chronic productive cough.
,2. A 23-year-old woman presents with episodic wheezing, chest
tightness, and symptoms worse at night. What is the most
appropriate first-line long-term controller?
A. Albuterol
B. Oral prednisone
C. Inhaled corticosteroids
D. Theophylline
Answer: C. Inhaled corticosteroids
Rationale: Inhaled corticosteroids are first-line maintenance
therapy for persistent asthma to reduce airway inflammation.
3. A patient presents with chest pain radiating to the left arm and ST
elevation in leads II, III, aVF. Which artery is most likely occluded?
A. LAD
B. Right coronary artery
C. Circumflex artery
D. Left main coronary artery
Answer: B. Right coronary artery
Rationale: Inferior wall MI (II, III, aVF) is most commonly due to
RCA occlusion.
,4. A 45-year-old woman has fatigue, weight gain, cold intolerance,
and elevated TSH. What is the most likely diagnosis?
A. Graves disease
B. Hashimoto thyroiditis
C. Subacute thyroiditis
D. Thyroid cancer
Answer: B. Hashimoto thyroiditis
Rationale: Elevated TSH with hypothyroid symptoms suggests
primary hypothyroidism, most commonly Hashimoto thyroiditis.
5. A patient presents with polyuria, polydipsia, and fasting glucose of
190 mg/dL. What is the most likely diagnosis?
A. Type 1 diabetes
B. Type 2 diabetes
C. Diabetes insipidus
D. SIADH
Answer: B. Type 2 diabetes
Rationale: Adult-onset hyperglycemia with insulin resistance
features is consistent with type 2 diabetes.
, 6. A 30-year-old woman presents with facial drooping on one side,
inability to close eye, and loss of forehead wrinkles. Diagnosis?
A. Stroke
B. Bell palsy
C. Myasthenia gravis
D. Trigeminal neuralgia
Answer: B. Bell palsy
Rationale: Peripheral facial nerve palsy affects upper and lower
face, distinguishing it from stroke.
7. A patient has tremor at rest, rigidity, and bradykinesia. Which
neurotransmitter is decreased?
A. Serotonin
B. Dopamine
C. GABA
D. Acetylcholine
Answer: B. Dopamine
Rationale: Parkinson disease involves degeneration of
dopaminergic neurons in the substantia nigra.
Questions With Correct Answers (Verified
Answers) Plus Rationales 2026 Q&A | Instant
Download Pdf
1. A 65-year-old man with a history of smoking presents with
progressive dyspnea and chronic cough producing sputum.
Spirometry shows FEV1/FVC of 55%. What is the most likely
diagnosis?
A. Asthma
B. COPD
C. Pulmonary fibrosis
D. Bronchiectasis
Answer: B. COPD
Rationale: COPD is characterized by persistent airflow limitation
with FEV1/FVC < 70%, most commonly due to smoking history
and chronic productive cough.
,2. A 23-year-old woman presents with episodic wheezing, chest
tightness, and symptoms worse at night. What is the most
appropriate first-line long-term controller?
A. Albuterol
B. Oral prednisone
C. Inhaled corticosteroids
D. Theophylline
Answer: C. Inhaled corticosteroids
Rationale: Inhaled corticosteroids are first-line maintenance
therapy for persistent asthma to reduce airway inflammation.
3. A patient presents with chest pain radiating to the left arm and ST
elevation in leads II, III, aVF. Which artery is most likely occluded?
A. LAD
B. Right coronary artery
C. Circumflex artery
D. Left main coronary artery
Answer: B. Right coronary artery
Rationale: Inferior wall MI (II, III, aVF) is most commonly due to
RCA occlusion.
,4. A 45-year-old woman has fatigue, weight gain, cold intolerance,
and elevated TSH. What is the most likely diagnosis?
A. Graves disease
B. Hashimoto thyroiditis
C. Subacute thyroiditis
D. Thyroid cancer
Answer: B. Hashimoto thyroiditis
Rationale: Elevated TSH with hypothyroid symptoms suggests
primary hypothyroidism, most commonly Hashimoto thyroiditis.
5. A patient presents with polyuria, polydipsia, and fasting glucose of
190 mg/dL. What is the most likely diagnosis?
A. Type 1 diabetes
B. Type 2 diabetes
C. Diabetes insipidus
D. SIADH
Answer: B. Type 2 diabetes
Rationale: Adult-onset hyperglycemia with insulin resistance
features is consistent with type 2 diabetes.
, 6. A 30-year-old woman presents with facial drooping on one side,
inability to close eye, and loss of forehead wrinkles. Diagnosis?
A. Stroke
B. Bell palsy
C. Myasthenia gravis
D. Trigeminal neuralgia
Answer: B. Bell palsy
Rationale: Peripheral facial nerve palsy affects upper and lower
face, distinguishing it from stroke.
7. A patient has tremor at rest, rigidity, and bradykinesia. Which
neurotransmitter is decreased?
A. Serotonin
B. Dopamine
C. GABA
D. Acetylcholine
Answer: B. Dopamine
Rationale: Parkinson disease involves degeneration of
dopaminergic neurons in the substantia nigra.
