COMSAE PHASE 1 FORM 114
STUDY GUIDE | COMPLETE
PRACTICE EXAM WITH VERIFIED
QUESTIONS, ACCURATE
ANSWERS GRADED A+ IN BOLD
ITALIC, AND DETAILED
EXPLANATIONS FOR
OSTEOPATHIC MEDICAL
STUDENTS 2026 UPDATE
drug for UC/Crohns - answer-sulfasalazine
pulmonary effects of CF - answer-chronic bronchitis an dbronchiectasis
osteoporosis affects what parts of bone? - answer-(spongy and ) trabecular bone mass
loss
imipramine - answer-TCA
SE: Tri-Cs
convulsions
coma
cardiotox
antichol effects- confusion in elderly; (acute glaucoma and orthostatic hypotension-
block alpha1)
viscerosomatic - answer-visceral disease --> somatic finding
,loratidine vs ranitidine - answer-loratidine: 2nd gen H1 blocker, doesnt cross BBB -->
less sedating
ranitidine: H2 receptor antagonist (like cimetidine)
cells w RBCs inside - answer-entaemoba histolytica
which type of pneumothorax causes tracheal deviation to the contra side? - answer-
tension
intracerebral hemorrhage adjacent to a lesion that contains a tangle of numerous
tortuous vessels - answer-AVM arteriovenous malformation
cavernous hemangioma - answer-benign tumor of liver, A/W VHL
anti-HepB surface antibody is only present in what pop - answer-recovered or
immunized
not in chronic or
proctalgia fugax - answer-levator ani syndrome
fasciculus is UMN or LMN lesion? - answer-LMN
ectopic gastric tissue - answer-meckels diverticulum
can also have ectopic pancreatic tissue
,remnant of vitelline duct
antibodies in hashimotos attacks - answer-thyroid peroxidase or antithyroglobulin
enlarged non tender thyroid
2 factors that influence starling curve - answer-x axis- preload (EDV)
y axis- stroke volume or CO
treatment for fibromyalgia - answer-TCA, SNRIs anticonvulsants
what blocks NE reuptake? - answer-TCA or SNRIs
possible complication of pagets bone disease - answer-osteocarcoma
what does Hct tell you? - answer-ratio of volume of RBCs compared to total blood
volume
probenecid - answer-inhibits reabsoprtion of uric acid in PCT
- also inhibits secretion of PCN
- can ppt uric acid calculi
2 causes of SCID - answer-ADA deficiency
(adenosine deaminase required for degradation of adenosim and deoxyadenosine
- in ADA deficiency, high levels of dATP --> toxicity in lymphocytes --> SCID
hypoplastic thymus
, lithiums effects on urination - answer-inhibits vasopression/ADH --> increased urinary
frequency
infertility drug that can result in multiple fetuses - answer-clomiphene (clones- multiple
babies)
antagonist at estrogen R in hypothalamus (thus inhibits normal negative feedback)
upregulates LH and FSH release from pituitary --> ovulation
used to treat PCOS but can cause ovarian enlargement, multiple fetuses
AFP levels in down syndrome - answer-low
GI malformation A/W down syndrome - answer-Hirschprungs- congenital aganglionic
megacolon
defective relaxation and peristalsis of rectum and distal sigmoid colon
failure to pass meconium, empty rectal vault, megacolon
myasthenia gravis associations - answer-thymoma, thymic hyperplasia
ptosis, diplopia, can affect chewing, swallowing, speaking, shoulders, respiration
tx for tinea - answer-azoles
beta blockers for asthma - answer-none- even beta 1s can be nonselective at higher
doses
STUDY GUIDE | COMPLETE
PRACTICE EXAM WITH VERIFIED
QUESTIONS, ACCURATE
ANSWERS GRADED A+ IN BOLD
ITALIC, AND DETAILED
EXPLANATIONS FOR
OSTEOPATHIC MEDICAL
STUDENTS 2026 UPDATE
drug for UC/Crohns - answer-sulfasalazine
pulmonary effects of CF - answer-chronic bronchitis an dbronchiectasis
osteoporosis affects what parts of bone? - answer-(spongy and ) trabecular bone mass
loss
imipramine - answer-TCA
SE: Tri-Cs
convulsions
coma
cardiotox
antichol effects- confusion in elderly; (acute glaucoma and orthostatic hypotension-
block alpha1)
viscerosomatic - answer-visceral disease --> somatic finding
,loratidine vs ranitidine - answer-loratidine: 2nd gen H1 blocker, doesnt cross BBB -->
less sedating
ranitidine: H2 receptor antagonist (like cimetidine)
cells w RBCs inside - answer-entaemoba histolytica
which type of pneumothorax causes tracheal deviation to the contra side? - answer-
tension
intracerebral hemorrhage adjacent to a lesion that contains a tangle of numerous
tortuous vessels - answer-AVM arteriovenous malformation
cavernous hemangioma - answer-benign tumor of liver, A/W VHL
anti-HepB surface antibody is only present in what pop - answer-recovered or
immunized
not in chronic or
proctalgia fugax - answer-levator ani syndrome
fasciculus is UMN or LMN lesion? - answer-LMN
ectopic gastric tissue - answer-meckels diverticulum
can also have ectopic pancreatic tissue
,remnant of vitelline duct
antibodies in hashimotos attacks - answer-thyroid peroxidase or antithyroglobulin
enlarged non tender thyroid
2 factors that influence starling curve - answer-x axis- preload (EDV)
y axis- stroke volume or CO
treatment for fibromyalgia - answer-TCA, SNRIs anticonvulsants
what blocks NE reuptake? - answer-TCA or SNRIs
possible complication of pagets bone disease - answer-osteocarcoma
what does Hct tell you? - answer-ratio of volume of RBCs compared to total blood
volume
probenecid - answer-inhibits reabsoprtion of uric acid in PCT
- also inhibits secretion of PCN
- can ppt uric acid calculi
2 causes of SCID - answer-ADA deficiency
(adenosine deaminase required for degradation of adenosim and deoxyadenosine
- in ADA deficiency, high levels of dATP --> toxicity in lymphocytes --> SCID
hypoplastic thymus
, lithiums effects on urination - answer-inhibits vasopression/ADH --> increased urinary
frequency
infertility drug that can result in multiple fetuses - answer-clomiphene (clones- multiple
babies)
antagonist at estrogen R in hypothalamus (thus inhibits normal negative feedback)
upregulates LH and FSH release from pituitary --> ovulation
used to treat PCOS but can cause ovarian enlargement, multiple fetuses
AFP levels in down syndrome - answer-low
GI malformation A/W down syndrome - answer-Hirschprungs- congenital aganglionic
megacolon
defective relaxation and peristalsis of rectum and distal sigmoid colon
failure to pass meconium, empty rectal vault, megacolon
myasthenia gravis associations - answer-thymoma, thymic hyperplasia
ptosis, diplopia, can affect chewing, swallowing, speaking, shoulders, respiration
tx for tinea - answer-azoles
beta blockers for asthma - answer-none- even beta 1s can be nonselective at higher
doses
