ANCC AGPCNP Practice Qs
(2026/2027) UPDATE|EXAM
QUESTIONS WITH MULTIPLE
CHOICES |VERIFIED & REVISED
ANSWERS (NEW)!!!
Anm18-year-
oldmfemalempatientmismbeingmfollowedmupmformacnembymthemnursempractitioner.mDuringmthemfacialm
exam,mpapulesmandmpustulesmaremnotedmmostlymonmthemforeheadmandmthemchinmareas.mThempatie
ntmhasmbeenmusingmover-the-
countermtopicalmantibioticmgelsmandmmedicatedmsoapmdailymform6mmonthsmwithoutmmuchmimprove
ment.mThemnursempractitionermwillmrecommend:
a.mIsotretinoinm(Accutane)
b.mTetracyclinem(Sumycin)
c.mClindamycinmtopicalmsolutionm(Cleocin-mT)
d.mMinoxidilm(Rogaine)m-mCORRECTmANSWERmb.mTetracyclinem(Sumycin)
First-linemtreatmentmformacnemvulgarismincludesmover-the-
countermmedicatedmsoapmandmwatermwithmtopicalmantibioticmgels.mThemnextmstepminmtreatmentmw
ouldmbemtheminitiationmofmoralmtetracycline.
Amyoungmadultmpresentsmformreassessmentmofmuncontrolledmasthmamsymptoms.mThempatientmismc
urrentlymtakingmanminhaledmshort-actingmbeta2-
agonistm(SABA)masmneededmandmreportsmdaytimemsymptomsmmoremthanm3mdays/week,mbutmnotmd
aily,mandmnighttimemawakeningsm4mtom5mtimes/week.mThempatient'smforcedmexpiratorymvolumem(F
EV1)mism80%mofmpredicted.mThemnursempractitionermupgradesmthempatientmtomthemnextmstagemofmtr
eatment,mwhichmincludes:
a.mBudesonidemwithmformoterol
,b.mBudesonidemwithmmontelukast
c.mCromolynmormnedocromil
d.mFluticasonemwithmsalmeterolm-mCORRECTmANSWERma.mBudesonidemwithmformoterol.
Thempatientmhasmmovedmfrommstepm2mtomstepm3monmthemasthmamclassificationmscale.mTherefore,ma
mlow-doseminhaledmcorticosteroidm(ICS)mplusmlong-actingmbeta-
agonistm(LABA)msuchmasmbudesonidemwithmformoterolmismanmappropriatemstartingmpoint.mFluticaso
nemwithmsalmeterolmismprescribedmifmthempatientmismatmstepm4;mbudesonidemwithmmontelukastmisma
nmalternative.mCromolynmandmnedocromilmhavembeenmdiscontinuedminmthemUnitedmStates.
Whichmofmthemfollowingmdrugsmcanmincreasemthemriskmofmbleedingminmpatientsmwhomaremreceivingm
anticoagulationmtherapymwithmwarfarinmsodiumm(Coumadin)?
a.mTrimethoprim-sulfamethoxazolem(BactrimmDS)
b.mCarafatem(Sucralfate)
c.mLosartanm(Cozaar)
d.mFurosemidem(Lasix)m-mCORRECTmANSWERma.mTrimethoprim-sulfamethoxazolem(BactrimmDS).
Warfarinmsodiumm(Coumadin)minteractsmwithmBactrimmandmwillmincreasemthemriskmofmbleeding;mth
erefore,mconcurrentmusemismcontraindicated.
Am22-year-oldmwomanmismgoingmonmam5-
daymcruisemformhermhoneymoon.mShemreportsmamhistorymofmseveremmotionmsickness.mWhichmofmth
emfollowingmmedicinesmcanmbemprescribedmformmotionmsickness?
a.mDimenhydrinatem(Dramamine)
b.mMetoclopramidem(Reglan)
c.mOndansetronm(Zofran)
,d.mScopolaminempatchm(TransdermmScop)m-
mCORRECTmANSWERmd.mScopolaminempatchm(TransdermmScop)
Scopolaminempatchm(TransdermmScop)mismamprescriptionmmedicinemthatmismusedmformmotion/seams
ickness.mItmismamsmall,mcircularmpatchmthatmismplacedmbehindmthemearmandmismeffectivemform3mdays.m
Advisemthempatientmtomapplymitm4mhoursmbeforemthemtripmtombemeffective.mBecausemthemquestionmi
smaskingmaboutmam"prescribed"mmedication,manmover-the-
counterm(OTC)mmedicine,msuchmasmDramamine,mismanmincorrectmresponse.mZofranmismindicatedmfor
mcancer-relatedmnauseamandmvomitingm(chemotherapy,mradiation,msurgery).
Themnursempractitionermismcompletingmamhealthmassessmentmonmam15-year-
oldmfemalempatientmwhomisminmthemofficemformhermannualmphysical.mThempatientmreportsmfeelingsmo
fmhopelessnessmandmsadnessmformseveralmmonths,mnomhistorymofmsuicidalmideations,mandmamstruggl
emwithmanorexia.mThempatientmscoresmanm11monmBeck'smDepressionmInventory.mWhichmantidepress
antmwillmthemnursempractitionermprescribe?
a.mSertralinem(Zoloft)
b.mLithiummcarbonatem(Eskalith)
c.mBupropionm(Wellbutrin)
d.mEscitalopramm(Lexapro)m-mCORRECTmANSWERmd.mEscitalopramm[Lexapro]
Escitaloprammismamsafemantidepressantmformanmadolescentmwhomhasmseveremdepressionmandmnomhi
storymofmsuicidalmideations.mSertralinemismnotmamsafemoptionmformpatientsmyoungermthanm24myearsm
ofmagembecausemofmincreasedmriskmofmsuicidalmideation.mBupropionmismanmatypicalmantidepressant
mandmismnotmamfirst-
linemtherapymformdepression.mItmismcontraindicatedminmpatientsmwithmanorexiamnervosa.mLithiummis
mindicatedmformpatientsmwithmbipolarmdisorder.
Whichminitialmtreatmentmwillmthemnursempractitionermprescribemtomam23-year-
oldmfemalemallergicmtomsulfamdrugsmwhomismdiagnosedmwithmacutemcystitis?
, a.mCephalexinm(Keflex)m500mmgmBIDm×m5mdays
b.mCiprofloxacinm(Cipro)m250mmgmBIDm×m3mdays
c.mNitrofurantoinm(Macrobid)m100mmgmBIDm×m5mdays
d.mAmoxicillinm500mmgmBIDm×m5mdaysm-
mCORRECTmANSWERmc.mNitrofurantoinm(Macrobid)m100mmgmBIDm×m5mdays
Nitrofurantoinmcanmbemsafelymadministeredmtomampatientmwithmamsulfamallergymtomtreatmacutemcyst
itismandmismthemfirstmlinemofmtreatment.mCephalexinmandmamoxicillinmarembeta-
lactammantibioticsmthatmcanmbemprescribedmformampatientmwhomhasmanmallergymtomsulfamandmnitrof
urantoin.mAmfluoroquinolone,msuchmasmciprofloxacin,mismrecommendedmformampatientmwhomismaller
gicmtomsulfamandmbeta-lactammdrugsmormhasmamsulfamallergymandmamknownmresistancemtombeta-
lactammantibiotics.
Am68-year-oldmpatientmrecentlymprescribedmcaridopa-
levodopam(Sinemet)mtellsmthemnursempractitionermthatmhemhasmbeenmbloatedmandmexperiencingmdi
fficultymwithmbowelmmovements.mWhichmmedicationmwillmthemnursempractitionermconsidermincorp
oratingmintomthemtreatmentmplan?
a.mSenna
b.mMethylnaltrexone
c.mMagnesiummcitrate
d.mPolyethylenemglycolm-mCORRECTmANSWERmd.mPolyethylenemglycol
Levodopa,manmantiparkinsonianmdrug,mcanmcausemconstipationminmanmoldermpatient.mThemfirst-
linemtreatmentmformthempatient'smconstipationmismosmoticmlaxativesmsuchmasmpolyethylenemglycol.m
Sennamismamstimulantmlaxativemthatmismamsecond-
linemtreatmentmformconstipationminmanmoldermadult.mMethylnaltrexonemismamperipherallymactingmm
u-opioidmantagonistmthatmactsmonmthemgastrointestinalmtractmtomdecreasemopioid-
inducedmconstipation.mMagnesium-
basedmlaxativesm(e.g.,mmagnesiummcitrate)mtakenmovermthemlongmtermmshouldmbemavoidedmbecaus
emofmthempotentialmofmtoxicity.
(2026/2027) UPDATE|EXAM
QUESTIONS WITH MULTIPLE
CHOICES |VERIFIED & REVISED
ANSWERS (NEW)!!!
Anm18-year-
oldmfemalempatientmismbeingmfollowedmupmformacnembymthemnursempractitioner.mDuringmthemfacialm
exam,mpapulesmandmpustulesmaremnotedmmostlymonmthemforeheadmandmthemchinmareas.mThempatie
ntmhasmbeenmusingmover-the-
countermtopicalmantibioticmgelsmandmmedicatedmsoapmdailymform6mmonthsmwithoutmmuchmimprove
ment.mThemnursempractitionermwillmrecommend:
a.mIsotretinoinm(Accutane)
b.mTetracyclinem(Sumycin)
c.mClindamycinmtopicalmsolutionm(Cleocin-mT)
d.mMinoxidilm(Rogaine)m-mCORRECTmANSWERmb.mTetracyclinem(Sumycin)
First-linemtreatmentmformacnemvulgarismincludesmover-the-
countermmedicatedmsoapmandmwatermwithmtopicalmantibioticmgels.mThemnextmstepminmtreatmentmw
ouldmbemtheminitiationmofmoralmtetracycline.
Amyoungmadultmpresentsmformreassessmentmofmuncontrolledmasthmamsymptoms.mThempatientmismc
urrentlymtakingmanminhaledmshort-actingmbeta2-
agonistm(SABA)masmneededmandmreportsmdaytimemsymptomsmmoremthanm3mdays/week,mbutmnotmd
aily,mandmnighttimemawakeningsm4mtom5mtimes/week.mThempatient'smforcedmexpiratorymvolumem(F
EV1)mism80%mofmpredicted.mThemnursempractitionermupgradesmthempatientmtomthemnextmstagemofmtr
eatment,mwhichmincludes:
a.mBudesonidemwithmformoterol
,b.mBudesonidemwithmmontelukast
c.mCromolynmormnedocromil
d.mFluticasonemwithmsalmeterolm-mCORRECTmANSWERma.mBudesonidemwithmformoterol.
Thempatientmhasmmovedmfrommstepm2mtomstepm3monmthemasthmamclassificationmscale.mTherefore,ma
mlow-doseminhaledmcorticosteroidm(ICS)mplusmlong-actingmbeta-
agonistm(LABA)msuchmasmbudesonidemwithmformoterolmismanmappropriatemstartingmpoint.mFluticaso
nemwithmsalmeterolmismprescribedmifmthempatientmismatmstepm4;mbudesonidemwithmmontelukastmisma
nmalternative.mCromolynmandmnedocromilmhavembeenmdiscontinuedminmthemUnitedmStates.
Whichmofmthemfollowingmdrugsmcanmincreasemthemriskmofmbleedingminmpatientsmwhomaremreceivingm
anticoagulationmtherapymwithmwarfarinmsodiumm(Coumadin)?
a.mTrimethoprim-sulfamethoxazolem(BactrimmDS)
b.mCarafatem(Sucralfate)
c.mLosartanm(Cozaar)
d.mFurosemidem(Lasix)m-mCORRECTmANSWERma.mTrimethoprim-sulfamethoxazolem(BactrimmDS).
Warfarinmsodiumm(Coumadin)minteractsmwithmBactrimmandmwillmincreasemthemriskmofmbleeding;mth
erefore,mconcurrentmusemismcontraindicated.
Am22-year-oldmwomanmismgoingmonmam5-
daymcruisemformhermhoneymoon.mShemreportsmamhistorymofmseveremmotionmsickness.mWhichmofmth
emfollowingmmedicinesmcanmbemprescribedmformmotionmsickness?
a.mDimenhydrinatem(Dramamine)
b.mMetoclopramidem(Reglan)
c.mOndansetronm(Zofran)
,d.mScopolaminempatchm(TransdermmScop)m-
mCORRECTmANSWERmd.mScopolaminempatchm(TransdermmScop)
Scopolaminempatchm(TransdermmScop)mismamprescriptionmmedicinemthatmismusedmformmotion/seams
ickness.mItmismamsmall,mcircularmpatchmthatmismplacedmbehindmthemearmandmismeffectivemform3mdays.m
Advisemthempatientmtomapplymitm4mhoursmbeforemthemtripmtombemeffective.mBecausemthemquestionmi
smaskingmaboutmam"prescribed"mmedication,manmover-the-
counterm(OTC)mmedicine,msuchmasmDramamine,mismanmincorrectmresponse.mZofranmismindicatedmfor
mcancer-relatedmnauseamandmvomitingm(chemotherapy,mradiation,msurgery).
Themnursempractitionermismcompletingmamhealthmassessmentmonmam15-year-
oldmfemalempatientmwhomisminmthemofficemformhermannualmphysical.mThempatientmreportsmfeelingsmo
fmhopelessnessmandmsadnessmformseveralmmonths,mnomhistorymofmsuicidalmideations,mandmamstruggl
emwithmanorexia.mThempatientmscoresmanm11monmBeck'smDepressionmInventory.mWhichmantidepress
antmwillmthemnursempractitionermprescribe?
a.mSertralinem(Zoloft)
b.mLithiummcarbonatem(Eskalith)
c.mBupropionm(Wellbutrin)
d.mEscitalopramm(Lexapro)m-mCORRECTmANSWERmd.mEscitalopramm[Lexapro]
Escitaloprammismamsafemantidepressantmformanmadolescentmwhomhasmseveremdepressionmandmnomhi
storymofmsuicidalmideations.mSertralinemismnotmamsafemoptionmformpatientsmyoungermthanm24myearsm
ofmagembecausemofmincreasedmriskmofmsuicidalmideation.mBupropionmismanmatypicalmantidepressant
mandmismnotmamfirst-
linemtherapymformdepression.mItmismcontraindicatedminmpatientsmwithmanorexiamnervosa.mLithiummis
mindicatedmformpatientsmwithmbipolarmdisorder.
Whichminitialmtreatmentmwillmthemnursempractitionermprescribemtomam23-year-
oldmfemalemallergicmtomsulfamdrugsmwhomismdiagnosedmwithmacutemcystitis?
, a.mCephalexinm(Keflex)m500mmgmBIDm×m5mdays
b.mCiprofloxacinm(Cipro)m250mmgmBIDm×m3mdays
c.mNitrofurantoinm(Macrobid)m100mmgmBIDm×m5mdays
d.mAmoxicillinm500mmgmBIDm×m5mdaysm-
mCORRECTmANSWERmc.mNitrofurantoinm(Macrobid)m100mmgmBIDm×m5mdays
Nitrofurantoinmcanmbemsafelymadministeredmtomampatientmwithmamsulfamallergymtomtreatmacutemcyst
itismandmismthemfirstmlinemofmtreatment.mCephalexinmandmamoxicillinmarembeta-
lactammantibioticsmthatmcanmbemprescribedmformampatientmwhomhasmanmallergymtomsulfamandmnitrof
urantoin.mAmfluoroquinolone,msuchmasmciprofloxacin,mismrecommendedmformampatientmwhomismaller
gicmtomsulfamandmbeta-lactammdrugsmormhasmamsulfamallergymandmamknownmresistancemtombeta-
lactammantibiotics.
Am68-year-oldmpatientmrecentlymprescribedmcaridopa-
levodopam(Sinemet)mtellsmthemnursempractitionermthatmhemhasmbeenmbloatedmandmexperiencingmdi
fficultymwithmbowelmmovements.mWhichmmedicationmwillmthemnursempractitionermconsidermincorp
oratingmintomthemtreatmentmplan?
a.mSenna
b.mMethylnaltrexone
c.mMagnesiummcitrate
d.mPolyethylenemglycolm-mCORRECTmANSWERmd.mPolyethylenemglycol
Levodopa,manmantiparkinsonianmdrug,mcanmcausemconstipationminmanmoldermpatient.mThemfirst-
linemtreatmentmformthempatient'smconstipationmismosmoticmlaxativesmsuchmasmpolyethylenemglycol.m
Sennamismamstimulantmlaxativemthatmismamsecond-
linemtreatmentmformconstipationminmanmoldermadult.mMethylnaltrexonemismamperipherallymactingmm
u-opioidmantagonistmthatmactsmonmthemgastrointestinalmtractmtomdecreasemopioid-
inducedmconstipation.mMagnesium-
basedmlaxativesm(e.g.,mmagnesiummcitrate)mtakenmovermthemlongmtermmshouldmbemavoidedmbecaus
emofmthempotentialmofmtoxicity.
