Osteopathic Medical School Board Readiness
Exam Questions With Correct Answers
(Verified Answers) Plus Rationales 2026 Q&A |
Instant Download Pdf
Question 1
A 23-year-old man presents with fatigue, pallor, and glossitis. Labs show
MCV 112 fL. Which condition is the most likely cause?
A. Iron deficiency anemia
B. Vitamin B12 deficiency
C. Acute blood loss
D. Thalassemia minor
E. Anemia of chronic disease
Answer: B
Rationale: Macrocytic anemia (MCV >100 fL) with neurologic or
mucosal findings such as glossitis strongly suggests vitamin B12
deficiency. Iron deficiency and thalassemia typically cause microcytic
,anemia, while acute blood loss and anemia of chronic disease are
usually normocytic.
Question 2
A patient has right lower quadrant pain, fever, and rebound tenderness
at McBurney’s point. What is the most likely diagnosis?
A. Diverticulitis
B. Appendicitis
C. Cholecystitis
D. Crohn disease
E. Ectopic pregnancy
Answer: B
Rationale: Classic migration of pain to the right lower quadrant with
peritoneal signs at McBurney’s point is highly suggestive of acute
appendicitis. Diverticulitis typically presents in the left lower
quadrant.
Question 3
,Which osteopathic manipulative treatment is best for a patient with rib
dysfunction characterized by exhalation restriction?
A. Rib raising
B. Muscle energy
C. HVLA to inhaled rib
D. Still technique
E. Counterstrain only
Answer: B
Rationale: Muscle energy is commonly used to treat rib dysfunctions
by engaging the restrictive barrier and using patient muscle
contraction to restore motion. HVLA may be used in inhaled
dysfunctions but is less appropriate here.
Question 4
A 60-year-old smoker has chronic cough and dyspnea. Spirometry
shows FEV1/FVC < 0.7. Diagnosis?
A. Asthma
B. COPD
C. Restrictive lung disease
, D. Pulmonary fibrosis
E. Pneumonia
Answer: B
Rationale: An FEV1/FVC ratio <0.7 indicates obstructive lung disease.
In a chronic smoker, COPD is most likely due to chronic bronchitis or
emphysema.
Question 5
Which structure is derived from the endoderm?
A. Skeletal muscle
B. Nervous system
C. Respiratory epithelium
D. Dermis
E. Bone
Answer: C
Rationale: Endoderm forms epithelial linings of the respiratory and
gastrointestinal tracts, as well as associated glands. The other options
are mesodermal or ectodermal derivatives.
Exam Questions With Correct Answers
(Verified Answers) Plus Rationales 2026 Q&A |
Instant Download Pdf
Question 1
A 23-year-old man presents with fatigue, pallor, and glossitis. Labs show
MCV 112 fL. Which condition is the most likely cause?
A. Iron deficiency anemia
B. Vitamin B12 deficiency
C. Acute blood loss
D. Thalassemia minor
E. Anemia of chronic disease
Answer: B
Rationale: Macrocytic anemia (MCV >100 fL) with neurologic or
mucosal findings such as glossitis strongly suggests vitamin B12
deficiency. Iron deficiency and thalassemia typically cause microcytic
,anemia, while acute blood loss and anemia of chronic disease are
usually normocytic.
Question 2
A patient has right lower quadrant pain, fever, and rebound tenderness
at McBurney’s point. What is the most likely diagnosis?
A. Diverticulitis
B. Appendicitis
C. Cholecystitis
D. Crohn disease
E. Ectopic pregnancy
Answer: B
Rationale: Classic migration of pain to the right lower quadrant with
peritoneal signs at McBurney’s point is highly suggestive of acute
appendicitis. Diverticulitis typically presents in the left lower
quadrant.
Question 3
,Which osteopathic manipulative treatment is best for a patient with rib
dysfunction characterized by exhalation restriction?
A. Rib raising
B. Muscle energy
C. HVLA to inhaled rib
D. Still technique
E. Counterstrain only
Answer: B
Rationale: Muscle energy is commonly used to treat rib dysfunctions
by engaging the restrictive barrier and using patient muscle
contraction to restore motion. HVLA may be used in inhaled
dysfunctions but is less appropriate here.
Question 4
A 60-year-old smoker has chronic cough and dyspnea. Spirometry
shows FEV1/FVC < 0.7. Diagnosis?
A. Asthma
B. COPD
C. Restrictive lung disease
, D. Pulmonary fibrosis
E. Pneumonia
Answer: B
Rationale: An FEV1/FVC ratio <0.7 indicates obstructive lung disease.
In a chronic smoker, COPD is most likely due to chronic bronchitis or
emphysema.
Question 5
Which structure is derived from the endoderm?
A. Skeletal muscle
B. Nervous system
C. Respiratory epithelium
D. Dermis
E. Bone
Answer: C
Rationale: Endoderm forms epithelial linings of the respiratory and
gastrointestinal tracts, as well as associated glands. The other options
are mesodermal or ectodermal derivatives.
