COMSAE Baseline Diagnostic Assessment
Questions With Correct Answers (Verified
Answers) Plus Rationales 2026 Q&A | Instant
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1. A 55-year-old man presents with exertional chest pain relieved by
rest. Which is the most likely underlying mechanism?
A. Coronary artery vasospasm
B. Atherosclerotic plaque with fixed stenosis
C. Pericardial inflammation
D. Aortic dissection
Correct answer: B. Atherosclerotic plaque with fixed stenosis
Rationale: Stable angina is most commonly caused by fixed
atherosclerotic narrowing of coronary arteries, leading to predictable
ischemia during increased oxygen demand.
2. Which vitamin deficiency is associated with pernicious anemia?
A. Vitamin B6
B. Vitamin B12
, C. Vitamin C
D. Vitamin K
Correct answer: B. Vitamin B12
Rationale: Pernicious anemia is caused by autoimmune destruction of
intrinsic factor, leading to impaired absorption of vitamin B12.
3. The primary site of iron absorption is the:
A. Stomach
B. Duodenum
C. Jejunum
D. Ileum
Correct answer: B. Duodenum
Rationale: Iron is primarily absorbed in the duodenum where acidic
conditions facilitate conversion to absorbable forms.
4. A patient has right lower quadrant pain and fever. Most likely
diagnosis?
A. Diverticulitis
B. Appendicitis
, C. Cholecystitis
D. Pancreatitis
Correct answer: B. Appendicitis
Rationale: Appendicitis classically presents with right lower quadrant
pain, fever, and leukocytosis due to inflammation of the appendix.
5. Which structure is primarily responsible for filtering blood plasma
in the kidney?
A. Loop of Henle
B. Proximal tubule
C. Glomerulus
D. Collecting duct
Correct answer: C. Glomerulus
Rationale: The glomerulus is responsible for ultrafiltration of plasma
based on size and charge.
6. Which organism is most commonly associated with peptic ulcer
disease?
A. Clostridium difficile
B. Helicobacter pylori
, C. Staphylococcus aureus
D. Escherichia coli
Correct answer: B. Helicobacter pylori
Rationale: H. pylori infection is a major cause of peptic ulcers due to
mucosal damage and increased acid production.
7. Which type of hypersensitivity is mediated by IgE?
A. Type I
B. Type II
C. Type III
D. Type IV
Correct answer: A. Type I
Rationale: Type I hypersensitivity involves IgE-mediated mast cell
degranulation (e.g., anaphylaxis, allergic rhinitis).
8. What is the primary neurotransmitter at the neuromuscular
junction?
A. Dopamine
B. Serotonin
Questions With Correct Answers (Verified
Answers) Plus Rationales 2026 Q&A | Instant
Download Pdf
1. A 55-year-old man presents with exertional chest pain relieved by
rest. Which is the most likely underlying mechanism?
A. Coronary artery vasospasm
B. Atherosclerotic plaque with fixed stenosis
C. Pericardial inflammation
D. Aortic dissection
Correct answer: B. Atherosclerotic plaque with fixed stenosis
Rationale: Stable angina is most commonly caused by fixed
atherosclerotic narrowing of coronary arteries, leading to predictable
ischemia during increased oxygen demand.
2. Which vitamin deficiency is associated with pernicious anemia?
A. Vitamin B6
B. Vitamin B12
, C. Vitamin C
D. Vitamin K
Correct answer: B. Vitamin B12
Rationale: Pernicious anemia is caused by autoimmune destruction of
intrinsic factor, leading to impaired absorption of vitamin B12.
3. The primary site of iron absorption is the:
A. Stomach
B. Duodenum
C. Jejunum
D. Ileum
Correct answer: B. Duodenum
Rationale: Iron is primarily absorbed in the duodenum where acidic
conditions facilitate conversion to absorbable forms.
4. A patient has right lower quadrant pain and fever. Most likely
diagnosis?
A. Diverticulitis
B. Appendicitis
, C. Cholecystitis
D. Pancreatitis
Correct answer: B. Appendicitis
Rationale: Appendicitis classically presents with right lower quadrant
pain, fever, and leukocytosis due to inflammation of the appendix.
5. Which structure is primarily responsible for filtering blood plasma
in the kidney?
A. Loop of Henle
B. Proximal tubule
C. Glomerulus
D. Collecting duct
Correct answer: C. Glomerulus
Rationale: The glomerulus is responsible for ultrafiltration of plasma
based on size and charge.
6. Which organism is most commonly associated with peptic ulcer
disease?
A. Clostridium difficile
B. Helicobacter pylori
, C. Staphylococcus aureus
D. Escherichia coli
Correct answer: B. Helicobacter pylori
Rationale: H. pylori infection is a major cause of peptic ulcers due to
mucosal damage and increased acid production.
7. Which type of hypersensitivity is mediated by IgE?
A. Type I
B. Type II
C. Type III
D. Type IV
Correct answer: A. Type I
Rationale: Type I hypersensitivity involves IgE-mediated mast cell
degranulation (e.g., anaphylaxis, allergic rhinitis).
8. What is the primary neurotransmitter at the neuromuscular
junction?
A. Dopamine
B. Serotonin
